Gemcitabine
CAS Number: 95058-81-4
Molecular Mass: 263.2 g/mol
Formula: C9H11F2N3O4
Smiles: O=C1N=C(N)C=CN1C2OC(CO)C(O)C2(F)F
Synonymes: Gemcitabine, Cytidine, 2′-deoxy-2′,2′-difluoro-2′-Deoxy-2′,2′-difluorocytidine, LY 188011, DDFC,2′,2′-Difluoro-2′-deoxycytidine, 2′,2′-Difluorodeoxycytidine, DFdC, NSC 613327, DFdCyd, Gamcitabine, Folfugem, Gemcel, GemLip, Zefei, FF 10832
Bioactivity: Gemcitabine is a chemotherapeutic agent used as monotherapy or in combination with other anticancer agents.
Solubility in Different Solvents
| Solvent | Temperature [K] | Crystal form | Solubility [mg/mL] | Reference |
|---|---|---|---|---|
| Water | 278.15 | Form A | 4.851? | [3] |
| Water | 283.15 | Form A | 6.679? | [3] |
| Water | 288.15 | Form A | 9.703? | [3] |
| Water | 293.15 | Form A | 13.384? | [3] |
| Water | 298.15 | Form A | 17.967? | [3] |
| Water | 303.15 | Form A | 23.662? | [3] |
| Water | 308.15 | Form A | 31.761? | [3] |
| Water | 313.15 | Form A | 41.865? | [3] |
| Water | 318.15 | Form A | 53.584? | [3] |
| Methanol | 278.15 | Form A | 60.092? | [3] |
| Methanol | 283.15 | Form A | 65.854? | [3] |
| Methanol | 288.15 | Form A | 71.785? | [3] |
| Methanol | 293.15 | Form A | 77.658? | [3] |
| Methanol | 298.15 | Form A | 84.387? | [3] |
| Methanol | 303.15 | Form A | 91.17? | [3] |
| Methanol | 308.15 | Form A | 98.984? | [3] |
| Methanol | 313.15 | Form A | 107.813? | [3] |
| Methanol | 318.15 | Form A | 118.035? | [3] |
| Ethanol | 278.15 | Form A | 17.522? | [3] |
| Ethanol | 283.15 | Form A | 19.606? | [3] |
| Ethanol | 288.15 | Form A | 22.144? | [3] |
| Ethanol | 293.15 | Form A | 25.082? | [3] |
| Ethanol | 298.15 | Form A | 28.514? | [3] |
| Ethanol | 303.15 | Form A | 32.514? | [3] |
| Ethanol | 308.15 | Form A | 36.769? | [3] |
| Ethanol | 313.15 | Form A | 41.33? | [3] |
| Ethanol | 318.15 | Form A | 46.145? | [3] |
| 1-Propanol | 278.15 | Form A | 5.82? | [3] |
| 1-Propanol | 283.15 | Form A | 6.538? | [3] |
| 1-Propanol | 288.15 | Form A | 7.295? | [3] |
| 1-Propanol | 293.15 | Form A | 8.172? | [3] |
| 1-Propanol | 298.15 | Form A | 9.154? | [3] |
| 1-Propanol | 303.15 | Form A | 10.272? | [3] |
| 1-Propanol | 308.15 | Form A | 11.461? | [3] |
| 1-Propanol | 313.15 | Form A | 12.817? | [3] |
| 1-Propanol | 318.15 | Form A | 14.373? | [3] |
| Isopropanol | 278.15 | Form A | 6.565? | [3] |
| Isopropanol | 283.15 | Form A | 7.282? | [3] |
| Isopropanol | 288.15 | Form A | 8.127? | [3] |
| Isopropanol | 293.15 | Form A | 8.98? | [3] |
| Isopropanol | 298.15 | Form A | 10.033? | [3] |
| Isopropanol | 303.15 | Form A | 11.176? | [3] |
| Isopropanol | 308.15 | Form A | 12.419? | [3] |
| Isopropanol | 313.15 | Form A | 13.767? | [3] |
| Isopropanol | 318.15 | Form A | 15.407? | [3] |
| Ethyl acetate | 278.15 | Form A | 0.022? | [3] |
| Ethyl acetate | 283.15 | Form A | 0.029? | [3] |
| Ethyl acetate | 288.15 | Form A | 0.038? | [3] |
| Ethyl acetate | 293.15 | Form A | 0.048? | [3] |
| Ethyl acetate | 298.15 | Form A | 0.058? | [3] |
| Ethyl acetate | 303.15 | Form A | 0.071? | [3] |
| Ethyl acetate | 308.15 | Form A | 0.084? | [3] |
| Ethyl acetate | 313.15 | Form A | 0.098? | [3] |
| Ethyl acetate | 318.15 | Form A | 0.114? | [3] |
| Carbon dioxide | 308.0 | - | 0.02241 | [4] |
Thermodynamic parameters of solution
| Solvent | Temperature [K] | Crystal form | ΔHsol [kJ/mol] | ΔSsol [J/mol/K] | ΔGsol [kJ/mol] | Reference |
|---|---|---|---|---|---|---|
| Water | 298.15 | Form A | 45.35 | 96.5 | 16.63 | [3] |
| Methanol | 298.15 | Form A | 14.37 | 13.06 | 10.49 | [3] |
| Ethanol | 298.15 | Form A | 19.51 | 23.77 | 12.44 | [3] |
| 1-Propanol | 298.15 | Form A | 17.47 | 9.32 | 14.69 | [3] |
| Isopropanol | 298.15 | Form A | 16.64 | 7.52 | 14.4 | [3] |
| Ethyl acetate | 298.15 | Form A | 30.99 | 14.39 | 26.71 | [3] |