Sildenafil citrate

Molecular Mass: 666.7 g/mol

Formula: C₂₈H₃₈N₆O₁₁S

Smiles: CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12.O=C(O)CC(O)(CC(=O)O)C(=O)O

Synonymes:

Sildenafil citrate, 171599-83-0, Revatio, VIAGRA, Caverta, LIQREV, Sildenafil (as citrate), NSC-744009, NSC-758669, BW9B0ZE037, DTXSID4046076, UK-92480-10, UK-92,480-10, DTXCID2026076, CHEBI:58987, 1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate, Sildenafil Powder,, Citrate, Sildenafil, Lactate, Sildenafil, Nitrate, Sildenafil, Sildenafil, Desmethyl, RefChem:6219, Sildenafil for Oral Suspension, NCX911, NCX 911, UK 9248010, UK 92480 10, UK 92,480 10, Sildenafil citrate [USAN], Sildenafil (citrate), MFCD02102122, Sildenafil citrate salt, 5-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 2-hydroxypropane-1,2,3-tricarboxylate, 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one, 2-hydroxypropane-1,2,3-tricarboxylic acid, UK 92480-10, sildenafilcitrate, 1-((3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate (1:1), 1-[[3-(4,7-dihydro-1-methyl-7-oxo-3-propyl-1h-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate, Piperazine, 1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1), CAS-171599-83-0, NCGC00159496-02, UK-92480, UNII-BW9B0ZE037, Duromist, Penegra, Viagra, , X-Excite, C28H38N6O11S, 1-[[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate (1:1), 5-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 2-hydroxypropane-1,2,3-tricarboxylate, 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 2-hydroxypropane-1,2,3-tricarboxylate, Sildenafil citrate?, Revatio (TN), Wan Ai Ke, Viagra (TN), VRBRIQUE, VYBRIQUE, Sildenafil citrate CRS, Viagra, Sildenafil citrate, CHEMBL1737, SCHEMBL33982, Sildenafil citrate (JAN/USP), orb1310584, orb3025103, SCHEMBL1652668, SILDENAFIL CITRATE [MI], SCHEMBL29424508, SILDENAFIL CITRATE [JAN], Sildenafil (citrate) (Standard), GHL-901, MSK8582, NVD-401, GLXC-06283, HMS3260C20, HMS3654B08, HMS5079I04, HY-15025AR, Pharmakon1600-01504099, SILDENAFIL CITRATE [VANDF], SILDENAFIL CITRATE [MART.], SILDENAFIL CITRATE [USP-RS], SILDENAFIL CITRATE [WHO-DD], Tox21_111717, Tox21_500099, EBC-11287, HY-15025A, MSK8582-100M, NSC744009, NSC758669, s1431, AKOS015856298, AKOS015951281, MSK8582-1000M, Sildenafil for peak identification CRS, Tox21_111717_1, AC-1310, CCG-213260, CS-1576, FS27829, KS-1112, NSC 744009, NSC 758669, SB17346, Sildenafil citrate - Bio-X trade mark, SILDENAFIL CITRATE [ORANGE BOOK], NCGC00095099-05, NCGC00260784-01, SILDENAFIL CITRATE [EP MONOGRAPH], BS164405, SILDENAFIL CITRATE [USP MONOGRAPH], SY038979, UK 92480, S0986, SW199664-3, D02229, EN300-19810912, Sildenafil citrate Solution in Methanol, 100ug/mL, SR-01000787181, Sildenafil citrate Solution in Methanol, 1000ug/mL, SR-01000787181-2, Q27126379, Sildenafil citrate, 1mg/ml in Methanol (as free base), F0001-2406, Sildenafil citrate, European Pharmacopoeia (EP) Reference Standard, Sildenafil citrate salt, European Pharmacopoeia (EP) Reference Standard, Sildenafil citrate, United States Pharmacopeia (USP) Reference Standard, 1-{[3-(6,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl}-4-methylpiperazone citrate, 5-[2-Ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phenyl]-1,3-d]pyrimidin-7-one-citrate, Sildenafil Citrate, Pharmaceutical Secondary Standard, Certified Reference Material, 1-[ 4-Ethoxy-3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenylsulfonyl]-4-methylpiperazine citra, 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1-h-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate, 2-Hydroxypropane-1,2,3-tricarboxylic acid--5-[2-ethoxy-5-(4-methylpiperazine-1-sulfonyl)phenyl]-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (1/1), 2-hydroxypropane-1,2,3-tricarboxylic acid, 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1H,4H,7H-pyrazolo[4,3-d]pyrimidin-7-one, 5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(4H)-one 2-hydroxypropane-1,2,3-tricarboxylate, 5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(4H)-one2-hydroxypropane-1,2,3-tricarboxylate, 5-(2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 2-hydroxypropane-1,2,3-tricarboxylate, 5-[2-Ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one 2-hydroxy-1,2,3-propanetricarboxylate (1:1), 5-[2-Ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1-methyl-3-propylpyrazolo[4,3-d]pyrimidin-7(4H)-one 2-Hydroxypropane-1,2,3-tricarboxylate, 5-[2-Ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl]-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one Citrate, citric acid, 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonyl-phenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one

Bioactivity: -

Solubility in Different Solvents

Solvent	Temperature [K]	Crystal form	Solubility [mg/mL]	Reference
1-Propanol	293.2	-	0.6054	[203]
1-Propanol	298.2	-	0.7124	[203]
1-Propanol	303.2	-	0.9532	[203]
1-Propanol	308.2	-	1.545	[203]
1-Propanol	313.2	-	2.595	[203]
Ethanol	293.2	-	1.325	[198]
Ethanol	293.2	-	0.9061	[199]
Ethanol	298.2	-	1.352	[198]
Ethanol	298.2	-	1.17	[199]
Ethanol	303.2	-	1.797	[198]
Ethanol	303.2	-	1.379	[199]
Ethanol	308.2	-	2.012	[198]
Ethanol	308.2	-	1.843	[199]
Ethanol	313.2	-	2.805	[198]
Ethanol	313.2	-	2.526	[199]
Ethylene Glycol	293.2	-	6.7	[204]
Ethylene Glycol	298.2	-	7.63	[204]
Ethylene Glycol	303.2	-	9.18	[204]
Ethylene Glycol	308.2	-	11.08	[204]
Ethylene Glycol	313.2	-	13.71	[204]
Isopropanol	293.2	-	0.3225	[200]
Isopropanol	293.2	-	0.4872	[201]
Isopropanol	298.2	-	0.4793	[200]
Isopropanol	298.2	-	0.61	[201]
Isopropanol	303.2	-	0.7274	[200]
Isopropanol	303.2	-	0.7567	[201]
Isopropanol	308.2	-	1.046	[200]
Isopropanol	308.2	-	0.8913	[201]
Isopropanol	313.2	-	1.423	[200]
Isopropanol	313.2	-	1.125	[201]
N-Methyl-2-pyrrolidone	293.2	-	370.0	[201]
N-Methyl-2-pyrrolidone	298.2	-	457.0	[201]
N-Methyl-2-pyrrolidone	303.2	-	520.0	[201]
N-Methyl-2-pyrrolidone	308.2	-	580.0	[201]
N-Methyl-2-pyrrolidone	313.2	-	647.2	[201]
Propylene Glycol	293.2	-	2.698	[199]
Propylene Glycol	293.2	-	3.552	[201]
Propylene Glycol	298.2	-	4.128	[199]
Propylene Glycol	298.2	-	3.838	[201]
Propylene Glycol	303.2	-	5.585	[199]
Propylene Glycol	303.2	-	4.06	[201]
Propylene Glycol	308.2	-	6.726	[199]
Propylene Glycol	308.2	-	4.216	[201]
Propylene Glycol	313.2	-	8.37	[199]
Propylene Glycol	313.2	-	8.926	[201]
Water	293.2	-	5.54	[198]
Water	293.2	-	3.661	[202]
Water	293.2	-	5.025	[200]
Water	293.2	-	3.768	[201]
Water	298.2	-	5.9	[198]
Water	298.2	-	4.608	[202]
Water	298.2	-	5.825	[200]
Water	298.2	-	4.608	[201]
Water	303.2	-	9.93	[198]
Water	303.2	-	4.966	[202]
Water	303.2	-	7.137	[200]
Water	303.2	-	5.444	[201]
Water	308.2	-	11.12	[198]
Water	308.2	-	6.203	[202]
Water	308.2	-	8.626	[200]
Water	308.2	-	6.387	[201]
Water	313.2	-	14.07	[198]
Water	313.2	-	6.996	[202]
Water	313.2	-	11.87	[200]
Water	313.2	-	7.509	[201]

Molecule 3D descriptors

Descriptor	Value
PMI1	3735.9393
PMI2	8879.1884
PMI3	9328.2294
NPR1	0.4005
NPR2	0.9519
RadiusOfGyration	4.0567
InertialShapeFactor	0.0003
Eccentricity	0.9163
Asphericity	0.2406
SpherocityIndex	0.4802
PBF	1.5303