Domperidone

CAS Number: 57808-66-9

Molecular Mass: 425.9 g/mol

Formula: C₂₂H₂₄ClN₅O₂

Smiles: O=c1[nH]c2ccccc2n1CCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1

Synonymes:

Domperidone, domperidone, 57808-66-9, Motilium, Domperidona, Domperidonum, R 33,812, R-33812, NSC299589, NSC-299589, KW 5338, NSC-759575, 5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone, DTXSID1045116, 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one, DTXCID9025116, CHEBI:31515, 5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolinyl)propyl]-4-piperidyl]-2-benzimidazolinone, Apo Domperidone, 5587267Z69, 2H-Benzimidazol-2-one, 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-, 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)propyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one, Domperidon, Motilium 10, R33812, 1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-1H-benzo[d]imidazol-2(3H)-one, 2H-Benzimidazol-2-one, 1,3-dihydro-5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-, 5-chloro-1-(1-(3-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one, 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one, 5-Chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one, Evoxin, Domilium, Equidone, Vivadone, Nu Domperidone, Equidone Gel, Novo Domperidone, PMS Domperidone, Motilium instants, ratio Domperidone, Domperidon TEVA, Hexal, Domperidon, Stada, Domperidon, Gamir, Domperidona, 1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo(d)imidazol-1-yl)piperidin-1-yl)propyl)-1H-benzo(d)imidazol-2(3H)-one, 5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)propyl)piperidin-4-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-one, 5-Chloro-1-(1-(3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one, 5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl)-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one, 5-chloro-1-(1-(3-(2-oxo-2,3-dihydrobenzo(d)imidazol-1-yl)propyl)piperidin-4-yl)-1H-benzo(d)imidazol-2(3H)-one, 6-chloro-3-(1-(3-(2-oxo-3H-benzimidazol-1-yl)propyl)piperidin-4-yl)-1H-benzimidazol-2-one, Maleate, Domperidone, RefChem:5776, Monohydrochloride, Domperidone, A03FA03, R33,812, 260-968-7, Nauzelin, 5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one, MFCD00069256, 4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine, MLS000069343, CHEMBL219916, s2461, 5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one, Motinorm, Costi, C22H24ClN5O2, Domperidonum [INN-Latin], Domperidona [INN-Spanish], Motillium, KW-5338, Motilium (TN), SMR000326802, CAS-57808-66-9, Lopac-D-122, SR-01000003002, EINECS 260-968-7, BRN 0903774, Domperidone CRS, Nauzelin OD, 5-chloro-1-{1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one, Domperidone [USAN:INN:BAN:JAN], Prestwick_794, NCI299589, UNII-5587267Z69, Domperidone (NIST), HS-0067, Domperidone (Motilium), Domperidone (Standard), Spectrum_000391, A1IVJ, Opera_ID_616, SpecPlus_000825, DOMPERIDONE [MI], Domperidone, pharma grade, Prestwick0_000461, Prestwick1_000461, Prestwick2_000461, Prestwick3_000461, Spectrum4_000087, DOMPERIDONE [INN], DOMPERIDONE [JAN], DOMPERIDONE [USAN], Biomol-NT_000022, DOMPERIDONE [VANDF], NCIStruc1_001686, NCIStruc2_001819, DOMPERIDONE [MART.], Lopac0_000427, R 33812, SCHEMBL43729, BSPBio_002350, DOMPERIDONE [WHO-DD], GTPL965, KBioGR_000354, KBioSS_000871, 5-24-02-00402 (Beilstein Handbook Reference), MLS000859942, MLS001306482, MLS002222324, DivK1c_006921, SPECTRUM2300212, SPBio_002501, BPBio1_000620, BPBio1_001185, orb1310958, DOMPERIDONE [GREEN BOOK], SCHEMBL29373565, Domperidone (JP18/USAN/INN), HY-B0411R, KBio1_001865, KBio2_000871, KBio2_003439, KBio2_006007, DOMPERIDONE [EP MONOGRAPH], HMS1922N04, HMS2089C14, HMS2093N22, HMS2096C21, HMS2230N18, HMS3261E16, HMS3269O13, HMS3370L03, HMS3413F15, HMS3656M21, HMS3677F15, HMS3713C21, HMS3884N19, HMS5081K07, Pharmakon1600-02300212, Domperidone 1.0 mg/ml in Methanol, HY-B0411, MSK10219, Tox21_110056, Tox21_500427, BBL028136, BDBM50241107, CCG-37870, EBC-11171, HB1888, NCGC00014670, NSC759575, STK622843, AKOS005555858, Tox21_110056_1, AC-2037, DB01184, Domperidone, powder, >=98% (HPLC), FD31879, LP00427, NSC 299589, NSC 759575, SDCCGSBI-0050412.P004, 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]-4-piperidyl]-1H-benzimidazol-2-one, NCGC00014670-01, NCGC00014670-02, NCGC00014670-03, NCGC00014670-04, NCGC00014670-05, NCGC00014670-06, NCGC00014670-07, NCGC00014670-08, NCGC00014670-09, NCGC00014670-10, NCGC00014670-11, NCGC00014670-12, NCGC00014670-13, NCGC00014670-14, NCGC00014670-16, NCGC00014670-17, NCGC00014670-28, NCGC00015306-01, NCGC00021472-02, NCGC00021472-03, NCGC00021472-04, NCGC00021472-05, NCGC00021472-06, NCGC00021472-07, NCGC00021472-08, NCGC00097773-01, NCGC00261112-01, 5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one, 5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one, BD164379, NCI60_002512, SMR000058969, SY052451, AB00052423, D4125, EU-0100427, NS00002818, SW196931-3, C75710, D01745, AB00052423-06, AB00052423-07, AB00052423_08, AB00052423_09, EN300-7411248, L000230, Q424238, SR-01000003002-2, SR-01000003002-4, SR-01000003002-7, BRD-K38305202-001-02-6, BRD-K38305202-001-08-3, BRD-K38305202-001-16-6, BRD-K38305202-001-17-4, BRD-K38305202-001-18-2, Domperidone, European Pharmacopoeia (EP) Reference Standard, 5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolyl)propyl]-4-piperidyl]benzimidazol-2-one, 1H-Benzimidazol-2-ol, 5-chloro-1-[1-[3-(2-hydroxy-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-, 2H-Benzimidazol-2-one,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-, 5-Chloro-1-[1-[3-(2-oxo-2,3-dihydro-1-benzoimidazolyl)propyl]-4-piperidyl]-1H-benzo[d]imidazol-2(3H)-one, 5-chloro-1-{1-[3-(1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)propyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one, 5-Chloro-1-{1-[3-(2-hydroxy-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-2,3-dihydro-1H-benzoimidazol-2-ol, 5-Chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-1,3-benzimidazol-1-yl)propyl]piperidin-4-yl}-1,3-dihydro-2H-1,3-benzimidazol-2-one, 5-Chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one(domperidone), DOMPERIDONE5-Chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one

Bioactivity: -

Solubility in Different Solvents

Solvent	Temperature [K]	Crystal form	Solubility [mg/mL]	Reference
1-Butanol	278.15	-	0.0578	[223]
1-Butanol	283.15	-	0.0768	[223]
1-Butanol	288.15	-	0.1023	[223]
1-Butanol	293.15	-	0.1323	[223]
1-Butanol	298.15	-	0.1692	[223]
1-Butanol	303.15	-	0.2049	[223]
1-Butanol	308.15	-	0.2507	[223]
1-Butanol	313.15	-	0.3206	[223]
1-Butanol	318.15	-	0.3896	[223]
1-Propanol	278.15	-	0.0681	[223]
1-Propanol	283.15	-	0.0833	[223]
1-Propanol	288.15	-	0.1086	[223]
1-Propanol	293.15	-	0.1451	[223]
1-Propanol	298.15	-	0.184	[223]
1-Propanol	303.15	-	0.2349	[223]
1-Propanol	308.15	-	0.2835	[223]
1-Propanol	313.15	-	0.3589	[223]
1-Propanol	318.15	-	0.436	[223]
Acetonitrile	278.15	-	0.001	[223]
Acetonitrile	283.15	-	0.0015	[223]
Acetonitrile	288.15	-	0.0021	[223]
Acetonitrile	293.15	-	0.0028	[223]
Acetonitrile	298.15	-	0.00371	[223]
Acetonitrile	303.15	-	0.0053	[223]
Acetonitrile	308.15	-	0.0069	[223]
Acetonitrile	313.15	-	0.0084	[223]
Acetonitrile	318.15	-	0.0115	[223]
Dimethyl sulfoxide	278.15	-	1.723	[223]
Dimethyl sulfoxide	283.15	-	2.061	[223]
Dimethyl sulfoxide	288.15	-	2.461	[223]
Dimethyl sulfoxide	293.15	-	2.934	[223]
Dimethyl sulfoxide	298.15	-	3.492	[223]
Dimethyl sulfoxide	303.15	-	4.151	[223]
Dimethyl sulfoxide	308.15	-	4.927	[223]
Dimethyl sulfoxide	313.15	-	5.837	[223]
Dimethyl sulfoxide	318.15	-	6.926	[223]
Dimethyl sulfoxide	323.15	-	8.292	[224]
Dimethyl sulfoxide	328.15	-	9.96	[224]
Dimethyl sulfoxide	333.15	-	12.12	[224]
Dimethylacetamide	278.15	-	3.762	[223]
Dimethylacetamide	283.15	-	4.516	[223]
Dimethylacetamide	288.15	-	5.378	[223]
Dimethylacetamide	293.15	-	6.269	[223]
Dimethylacetamide	298.15	-	7.239	[223]
Dimethylacetamide	303.15	-	8.295	[223]
Dimethylacetamide	308.15	-	9.455	[223]
Dimethylacetamide	313.15	-	10.59	[223]
Dimethylacetamide	318.15	-	11.8	[223]
Dimethylformamide	278.15	-	0.4176	[223]
Dimethylformamide	283.15	-	0.5533	[223]
Dimethylformamide	288.15	-	0.7286	[223]
Dimethylformamide	293.15	-	0.9422	[223]
Dimethylformamide	298.15	-	1.227	[223]
Dimethylformamide	303.15	-	1.544	[223]
Dimethylformamide	308.15	-	2.008	[223]
Dimethylformamide	313.15	-	2.553	[223]
Dimethylformamide	318.15	-	3.1	[223]
Dimethylformamide	323.15	-	3.64	[224]
Dimethylformamide	328.15	-	4.22	[224]
Dimethylformamide	333.15	-	4.834	[224]
Ethanol	278.15	-	0.06344	[223]
Ethanol	283.15	-	0.0806	[223]
Ethanol	288.15	-	0.1081	[223]
Ethanol	293.15	-	0.136	[223]
Ethanol	298.15	-	0.1654	[223]
Ethanol	303.15	-	0.2117	[223]
Ethanol	308.15	-	0.2587	[223]
Ethanol	313.15	-	0.3236	[223]
Ethanol	318.15	-	0.3797	[223]
Ethylene Glycol	278.15	-	0.0854	[223]
Ethylene Glycol	283.15	-	0.1101	[223]
Ethylene Glycol	288.15	-	0.1408	[223]
Ethylene Glycol	293.15	-	0.1686	[223]
Ethylene Glycol	298.15	-	0.2232	[223]
Ethylene Glycol	303.15	-	0.2636	[223]
Ethylene Glycol	308.15	-	0.3352	[223]
Ethylene Glycol	313.15	-	0.4198	[223]
Ethylene Glycol	318.15	-	0.4958	[223]
Isobutanol	278.15	-	0.04914	[223]
Isobutanol	283.15	-	0.0627	[223]
Isobutanol	288.15	-	0.0832	[223]
Isobutanol	293.15	-	0.1026	[223]
Isobutanol	298.15	-	0.1298	[223]
Isobutanol	303.15	-	0.1676	[223]
Isobutanol	308.15	-	0.2081	[223]
Isobutanol	313.15	-	0.2565	[223]
Isobutanol	318.15	-	0.3225	[223]
Isopropanol	278.15	-	0.045	[223]
Isopropanol	283.15	-	0.05584	[223]
Isopropanol	288.15	-	0.0813	[223]
Isopropanol	293.15	-	0.1026	[223]
Isopropanol	293.15	-	0.1031	[224]
Isopropanol	298.15	-	0.1255	[223]
Isopropanol	298.15	-	0.127	[224]
Isopropanol	303.15	-	0.151	[223]
Isopropanol	308.15	-	0.1892	[223]
Isopropanol	313.15	-	0.2359	[223]
Isopropanol	318.15	-	0.2931	[223]
Isopropanol	323.15	-	0.3486	[224]
Isopropanol	328.15	-	0.4122	[224]
Isopropanol	333.15	-	0.478	[224]
Methanol	278.15	-	0.08766	[223]
Methanol	283.15	-	0.1052	[223]
Methanol	288.15	-	0.1275	[223]
Methanol	293.15	-	0.1685	[223]
Methanol	298.15	-	0.2165	[223]
Methanol	303.15	-	0.266	[223]
Methanol	308.15	-	0.3278	[223]
Methanol	313.15	-	0.4139	[223]
Methanol	318.15	-	0.4999	[223]
Water	278.15	-	0.0021	[223]
Water	283.15	-	0.0025	[223]
Water	288.15	-	0.0033	[223]
Water	293.15	-	0.0041	[223]
Water	298.15	-	0.0052	[223]
Water	303.15	-	0.0065	[223]
Water	308.15	-	0.0079	[223]
Water	313.15	-	0.0098	[223]
Water	318.15	-	0.012	[223]
Water	323.15	-	0.0149	[224]
Water	328.15	-	0.018	[224]
Water	333.15	-	0.0217	[224]

Molecule 3D descriptors

Descriptor	Value
PMI1	1054.1113
PMI2	12721.2260
PMI3	12844.0761
NPR1	0.0821
NPR2	0.9904
RadiusOfGyration	5.5901
InertialShapeFactor	0.0009
Eccentricity	0.9966
Asphericity	0.7766
SpherocityIndex	0.1661
PBF	0.9852