Dapsone

CAS Number: 80-08-0

Molecular Mass: 248.3 g/mol

Formula: C₁₂H₁₂N₂O₂S

Smiles: Nc1ccc(S(=O)(=O)c2ccc(N)cc2)cc1

Synonymes:

Dapsone, dapsone, 80-08-0, 4,4'-Sulfonyldianiline, Diaphenylsulfone, 4,4'-Diaminodiphenyl sulfone, Dapson, 4,4'-Diaminodiphenylsulfone, DADPS, Diphenasone, Novophone, Disulone, Sulfona, 4-Aminophenyl sulfone, Avlosulfone, Croysulfone, Diaphenylsulfon, Avlosulfon, Dumitone, Eporal, Udolac, Bis(4-aminophenyl) sulfone, Dapsonum, Sulfadione, Sulphadione, Aczone, Diphone, p-Aminophenyl sulfone, Metabolite C, Sumicure S, Avlosulphone, Croysulphone, Sulfona-MAE, Diaphenylsulphon, Diaphenylsulphone, Sulphonyldianiline, Bis(p-aminophenyl) sulfone, Dubronax, 4-(4-aminophenyl)sulfonylaniline, Dapsona, Tarimyl, p,p-Sulphonylbisbenzamine, 4,4'-Dapsone, Diaminodiphenyl sulfone, Sulfone ucb, Sulfonyldianiline, p,p-Sulphonylbisbenzenamine, Diaminodiphenylsulfone, 4,4'-Sulfonylbisaniline, p,p'-Diaminodiphenyl sulfone, NSC-6091, Di(4-aminophenyl) sulfone, Benzenamine, 4,4'-sulfonylbis-, p,p-Sulphonyldianiline, Bis(4-aminophenyl)sulfone, Di(p-aminophenyl) sulfone, p,p'-sulfonyldianiline, 4,4'-Sulfonylbisbenzamine, p,p-Sulfonylbisbenzamine, Diaminodifenilsulfona, 4,4'-Sulfonylbisbenzenamine, Di(p-aminophenyl)sulphone, Araldite HT 976, p,p-Sulfonylbisbenzenamine, Bis(p-aminophenyl)sulphone, Di(4-aminophenyl)sulphone, Bis(4-aminophenyl)sulphone, p,p-Diaminodiphenyl sulphone, N,N'-Diphenyl sulfondiamide, Servidapson, 4,4'-Sulphonyldianiline, Di(4-aminophenyl)sulfone, 1,1'-Sulfonylbis(4-aminobenzene), Hardener HT 976, DDS (pharmaceutical), 4,4'-Sulphonylbisbenzamine, 4,4'-Sulphonylbisbenzenamine, 4,4-Diaminodifenylsulfon, 4,4'-Diaminodiphenyl sulphone, Diamino-4,4'-diphenyl sulfone, WR 448, Diamino-4,4'-diphenyl sulphone, NSC 6091D, NCI-C01718, Aniline, 4,4'-sulfonyldi-, 1,1'-Sulphonylbis(4-aminobenzene), 4,4'-Diaminodiphenyl suphone, HT 976, 1358F, DTXSID4020371, 4-(4-aminobenzenesulfonyl)aniline, F 1358, 1,1'-Sulfonylbis[4-aminobenzene], 4,4'-Sulfonylbisbenzeneamine, HY 976, 4,4'-Sulfonyldianilin, NSC 6091, Sulfone, diphenyl, 4,4'-diamino-, CHEBI:4325, AI3-08087, NSC-6091D, J04BA02, NSC6091, 4-(4-amino-benzenesulfonyl)-phenylamine, DTXCID00371, 8W5C518302, 4-(4-aminophenylsulfonyl)aniline, 4-(4-aminophenylsulfonyl)benzenamine, 4,4'-diaminophenyl sulfone, 4,4' Diaminophenyl Sulfone, Sulfone, 4,4'-Diaminophenyl, Daspone, Undolac, Dapsone Tablets, Dapsone 25 mg, Dapsone 100 mg, Dapsone Gel, 5%, RefChem:5731, 4,4'-sulfonylbis(benzenamine), D10AX05, 201-248-4, DDS, pharmaceutical, DDS, 4-[(4-aminobenzene)sulfonyl]aniline, 4-[(4-aminophenyl)sulfonyl]aniline, MFCD00007887, Diaphenylsulfone (JAN), CHEMBL1043, MLS000069409, Sulfanona-mae, Sulfon-mere, 4,4'-DDS, s4612, NCGC00016322-08, SMR000059064, Sulphon-mere, 4,4'-DIAMINO-15N2-DIPHENYL SULFONE, Dapsonum [INN-Latin], Dapsona [INN-Spanish], DSS (VAN), DIAPHENYLSULFONE [JAN], 4-Aminophenylsulfone, DDS, diaphenylsulfone, Atrisone, Diaminodifenilsulfona [Spanish], 4,4-Diaminodifenylsulfon [Czech], 4-[(4-Aminophenyl)sulfonyl]phenylamine, CAS-80-08-0, CCRIS 192, Dapsone (USP), Aczone (TN), 4,4'-diamino diphenyl sulphone, HSDB 5073, 4,4'-Sulfonyldianiline (Dapsone), SR-01000002976, EINECS 201-248-4, (4-sulfanilylphenyl)amine, BRN 0788055, Diaphenyl sulfone, Dapsone [USAN:USP:INN:BAN], Dapsone RS, Dapsone CRS, UNII-8W5C518302, Prestwick_152, ALBB-005917, Dapsone (Standard), IN-201, BIS SULFONE, 4,4''-dapsone, Spectrum_000888, DAPSONE [VANDF], Aniline,4'-sulfonyldi-, DAPSONE [HSDB], DAPSONE [IARC], DAPSONE [USAN], DAPSONE [INN], DAPSONE [MI], DAPSONE [MART.], Opera_ID_1950, Prestwick0_000035, Prestwick1_000035, Prestwick2_000035, Prestwick3_000035, Spectrum2_001133, Spectrum3_000375, Spectrum4_000310, Spectrum5_000825, WLN: ZR DSWR DZ, 4,4''-sulfonyldianiline, DAPSONE [USP-RS], DAPSONE [WHO-DD], DAPSONE [WHO-IP], 4,4''-sulfonylbisaniline, 4'-Diaminodiphenyl sulfone, Epitope ID:766884, EC 201-248-4, 4,4'-Sulfonyldiphenylamine, Benzenamine,4'-sulfonylbis-, Oprea1_143052, SCHEMBL21428, BSPBio_000129, BSPBio_002129, CBDivE_013582, Dianiline, 4,4'-sulfonyl-, KBioGR_000900, KBioSS_001368, MLS001055349, MLS001076146, 4,4''-Sulfonylbisbenzenamine, 4,4'-Sulfonylbis[benzamine], 4-Aminophenyl sulfone, 97%, BIDD:GT0770, DAPSONE [EP IMPURITY], DAPSONE [ORANGE BOOK], DivK1c_000573, p,p''-diaminodiphenyl sulfone, SPECTRUM1500222, SPBio_001025, SPBio_002050, DAPSONE [EP MONOGRAPH], 4,4''-diaminodiphenyl sulfone, 4,4'-diamino diphenyl sulfone, BPBio1_000143, orb1310195, orb3139509, SCHEMBL1219599, DAPSONE [USP MONOGRAPH], DAPSONUM [WHO-IP LATIN], GTPL10934, HMS501M15, HY-B0688R, KBio1_000573, KBio2_001368, KBio2_003936, KBio2_006504, KBio3_001349, MSK7106, NINDS_000573, HMS1568G11, HMS1920C14, HMS2091K04, HMS2095G11, HMS2231G09, HMS3259C13, HMS3369B11, HMS3712G11, HMS5083H21, HMS6018G07, Pharmakon1600-01500222, Dapson 100 microg/mL in Methanol, HY-B0688, 1,1''-sulfonylbis(4-aminobenzene), Tox21_110371, Tox21_201347, Tox21_300558, BBL002412, BDBM50029764, CCG-40260, EBC-03730, MSK7106-100M, NSC756716, SBB003168, STK387118, AKOS000119322, MSK7106-1000M, Tox21_110371_1, DB00250, FD20798, HT 9664, KS-1450, NC00488, NSC-756716, IDI1_000573, Dapsone Solution in Methanol, 100ug/mL, NCGC00016322-01, NCGC00016322-02, NCGC00016322-03, NCGC00016322-04, NCGC00016322-05, NCGC00016322-06, NCGC00016322-07, NCGC00016322-09, NCGC00016322-10, NCGC00016322-13, NCGC00023946-03, NCGC00023946-04, NCGC00023946-05, NCGC00023946-06, NCGC00254533-01, NCGC00258899-01, Sulphadione,4,4'-sulfonylbisbenzeneamine, AC-10922, 4-[(4-Aminophenyl)sulfonyl]phenylamine #, Dapsone Solution in Methanol, 1000ug/mL, SBI-0051331.P003, DB-056406, AB00051962, D0089, Dapsone, VETRANAL(TM), analytical standard, NS00000683, ST50308134, T0891, 4 inverted exclamation marka-Sulfonyldianiline, EN300-19042, C07666, D00592, H23984, AB00051962_19, F358228, Q422226, 4 inverted exclamation marka-Diaminodiphenyl sulfone, SR-01000002976-2, SR-01000002976-4, 4,4 inverted exclamation marka-Diaminodiphenyl sulfone, BRD-K62363391-001-05-8, BRD-K62363391-001-15-7, BRD-K62363391-001-24-9, SULFACETAMIDE SODIUM IMPURITY D [EP IMPURITY], Dapsone, British Pharmacopoeia (BP) Reference Standard, Dapsone, European Pharmacopoeia (EP) Reference Standard, F0266-3067, Z104472374, Dapsone, United States Pharmacopeia (USP) Reference Standard, Dapsone, Pharmaceutical Secondary Standard, Certified Reference Material

Bioactivity: -

Solubility in Different Solvents

Solvent	Temperature [K]	Crystal form	Solubility [mg/mL]	Reference
1,4-Dioxane	288.15	-	33.86	[233]
1,4-Dioxane	293.15	-	39.38	[233]
1,4-Dioxane	298.15	-	45.16	[233]
1,4-Dioxane	303.15	-	52.34	[233]
1,4-Dioxane	308.15	-	60.01	[233]
1,4-Dioxane	313.15	-	68.82	[233]
1,4-Dioxane	318.15	-	78.89	[233]
1,4-Dioxane	323.15	-	89.54	[233]
1-Butanol	283.15	-	3.506	[231]
1-Butanol	288.15	-	4.569	[231]
1-Butanol	293.15	-	4.763	[231]
1-Butanol	298.15	-	5.851	[231]
1-Butanol	303.15	-	6.688	[231]
1-Butanol	308.15	-	7.167	[231]
1-Butanol	313.15	-	8.572	[231]
1-Butanol	318.15	-	9.79	[231]
1-Butanol	323.15	-	11.2	[231]
1-Pentanol	283.15	-	1.88	[231]
1-Pentanol	288.15	-	2.3	[231]
1-Pentanol	293.15	-	2.918	[231]
1-Pentanol	298.15	-	3.45	[231]
1-Pentanol	303.15	-	3.847	[231]
1-Pentanol	308.15	-	4.955	[231]
1-Pentanol	313.15	-	5.656	[231]
1-Pentanol	318.15	-	6.553	[231]
1-Pentanol	323.15	-	7.219	[231]
1-Propanol	278.15	-	9.85	[233]
1-Propanol	283.15	-	12.1	[233]
1-Propanol	288.15	-	14.56	[233]
1-Propanol	293.15	-	17.4	[233]
1-Propanol	298.15	-	20.64	[233]
1-Propanol	303.15	-	24.45	[233]
1-Propanol	308.15	-	29.08	[233]
1-Propanol	313.15	-	34.13	[233]
1-Propanol	318.15	-	39.71	[233]
1-Propanol	323.15	-	45.91	[233]
2-Butanol	283.15	-	2.304	[231]
2-Butanol	288.15	-	2.925	[231]
2-Butanol	293.15	-	3.54	[231]
2-Butanol	298.15	-	4.336	[231]
2-Butanol	303.15	-	4.933	[231]
2-Butanol	308.15	-	6.237	[231]
2-Butanol	313.15	-	7.191	[231]
2-Butanol	318.15	-	8.531	[231]
2-Butanol	323.15	-	9.784	[231]
Acetone	278.15	-	183.6	[232]
Acetone	283.15	-	228.1	[231]
Acetone	283.15	-	215.1	[232]
Acetone	288.15	-	256.5	[231]
Acetone	288.15	-	249.8	[232]
Acetone	293.15	-	298.3	[231]
Acetone	293.15	-	292.1	[232]
Acetone	298.15	-	324.5	[231]
Acetone	298.15	-	344.9	[232]
Acetone	303.15	-	366.9	[231]
Acetone	303.15	-	397.8	[232]
Acetone	308.15	-	446.4	[231]
Acetone	308.15	-	459.4	[232]
Acetone	313.15	-	523.6	[231]
Acetone	313.15	-	538.6	[232]
Acetone	318.15	-	602.8	[231]
Acetone	318.15	-	618.2	[232]
Acetone	323.15	-	771.5	[231]
Acetone	323.15	-	723.4	[232]
Butyl acetate	283.15	-	6.425	[231]
Butyl acetate	288.15	-	6.854	[231]
Butyl acetate	293.15	-	7.051	[231]
Butyl acetate	298.15	-	7.143	[231]
Butyl acetate	303.15	-	7.91	[231]
Butyl acetate	308.15	-	8.103	[231]
Butyl acetate	313.15	-	8.459	[231]
Butyl acetate	318.15	-	8.765	[231]
Butyl acetate	323.15	-	9.351	[231]
Ethanol	278.15	-	12.95	[232]
Ethanol	283.15	-	15.71	[231]
Ethanol	283.15	-	14.74	[232]
Ethanol	288.15	-	16.86	[231]
Ethanol	288.15	-	16.71	[232]
Ethanol	293.15	-	18.73	[231]
Ethanol	293.15	-	19.1	[232]
Ethanol	298.15	-	20.31	[231]
Ethanol	298.15	-	21.44	[232]
Ethanol	303.15	-	23.62	[231]
Ethanol	303.15	-	24.11	[232]
Ethanol	308.15	-	24.76	[231]
Ethanol	308.15	-	26.87	[232]
Ethanol	313.15	-	28.06	[231]
Ethanol	313.15	-	29.93	[232]
Ethanol	318.15	-	33.18	[231]
Ethanol	318.15	-	33.92	[232]
Ethanol	323.15	-	38.49	[231]
Ethanol	323.15	-	37.74	[232]
Ethyl acetate	278.15	-	25.18	[232]
Ethyl acetate	283.15	-	26.31	[231]
Ethyl acetate	283.15	-	25.98	[232]
Ethyl acetate	288.15	-	27.22	[231]
Ethyl acetate	288.15	-	26.93	[232]
Ethyl acetate	293.15	-	27.36	[231]
Ethyl acetate	293.15	-	27.79	[232]
Ethyl acetate	298.15	-	27.97	[231]
Ethyl acetate	298.15	-	28.6	[232]
Ethyl acetate	303.15	-	29.0	[231]
Ethyl acetate	303.15	-	29.36	[232]
Ethyl acetate	308.15	-	29.31	[231]
Ethyl acetate	308.15	-	30.22	[232]
Ethyl acetate	313.15	-	30.94	[231]
Ethyl acetate	313.15	-	31.14	[232]
Ethyl acetate	318.15	-	31.63	[231]
Ethyl acetate	318.15	-	31.95	[232]
Ethyl acetate	323.15	-	33.01	[231]
Ethyl acetate	323.15	-	32.74	[232]
Ethyl propionate	283.15	-	14.17	[231]
Ethyl propionate	288.15	-	14.32	[231]
Ethyl propionate	293.15	-	14.67	[231]
Ethyl propionate	298.15	-	15.3	[231]
Ethyl propionate	303.15	-	15.58	[231]
Ethyl propionate	308.15	-	16.6	[231]
Ethyl propionate	313.15	-	17.26	[231]
Ethyl propionate	318.15	-	17.63	[231]
Ethyl propionate	323.15	-	18.02	[231]
Isobutanol	283.15	-	1.938	[231]
Isobutanol	288.15	-	2.075	[231]
Isobutanol	293.15	-	2.571	[231]
Isobutanol	298.15	-	2.866	[231]
Isobutanol	303.15	-	3.271	[231]
Isobutanol	308.15	-	4.296	[231]
Isobutanol	313.15	-	5.048	[231]
Isobutanol	318.15	-	5.885	[231]
Isobutanol	323.15	-	7.345	[231]
Isopropanol	278.15	-	8.775	[233]
Isopropanol	283.15	-	10.67	[233]
Isopropanol	288.15	-	12.72	[233]
Isopropanol	293.15	-	15.03	[233]
Isopropanol	298.15	-	18.04	[233]
Isopropanol	303.15	-	21.46	[233]
Isopropanol	308.15	-	25.72	[233]
Isopropanol	313.15	-	30.77	[233]
Isopropanol	318.15	-	36.74	[233]
Isopropanol	323.15	-	42.96	[233]
Methanol	278.15	-	32.24	[232]
Methanol	283.15	-	41.73	[231]
Methanol	283.15	-	37.92	[232]
Methanol	288.15	-	46.64	[231]
Methanol	288.15	-	44.38	[232]
Methanol	293.15	-	50.94	[231]
Methanol	293.15	-	51.4	[232]
Methanol	298.15	-	55.7	[231]
Methanol	298.15	-	59.85	[232]
Methanol	303.15	-	63.74	[231]
Methanol	303.15	-	67.99	[232]
Methanol	308.15	-	71.56	[231]
Methanol	308.15	-	77.88	[232]
Methanol	313.15	-	79.69	[231]
Methanol	313.15	-	89.21	[232]
Methanol	318.15	-	94.5	[231]
Methanol	318.15	-	101.2	[232]
Methanol	323.15	-	112.3	[231]
Methanol	323.15	-	115.9	[232]
Methyl acetate	283.15	-	68.94	[231]
Methyl acetate	288.15	-	72.22	[231]
Methyl acetate	293.15	-	73.86	[231]
Methyl acetate	298.15	-	76.14	[231]
Methyl acetate	303.15	-	79.89	[231]
Methyl acetate	308.15	-	83.11	[231]
Methyl acetate	313.15	-	88.71	[231]
Methyl acetate	318.15	-	95.39	[231]
Methyl acetate	323.15	-	100.3	[231]
Water	278.15	-	0.0187	[233]
Water	283.15	-	0.03205	[233]
Water	288.15	-	0.0539	[233]
Water	293.15	-	0.09259	[233]
Water	298.15	-	0.1465	[233]
Water	303.15	-	0.2244	[233]
Water	308.15	-	0.345	[233]
Water	313.15	-	0.5064	[233]
Water	318.15	-	0.716	[233]
Water	323.15	-	0.9853	[233]
isopropyl acetate	283.15	-	9.743	[231]
isopropyl acetate	288.15	-	9.788	[231]
isopropyl acetate	293.15	-	9.896	[231]
isopropyl acetate	298.15	-	10.11	[231]
isopropyl acetate	303.15	-	10.66	[231]
isopropyl acetate	308.15	-	10.68	[231]
isopropyl acetate	313.15	-	10.67	[231]
isopropyl acetate	318.15	-	11.46	[231]
isopropyl acetate	323.15	-	11.97	[231]

Molecule 3D descriptors

Descriptor	Value
PMI1	677.5672
PMI2	2023.4925
PMI3	2302.1498
NPR1	0.2943
NPR2	0.8790
RadiusOfGyration	3.1741
InertialShapeFactor	0.0013
Eccentricity	0.9557
Asphericity	0.3618
SpherocityIndex	0.3445
PBF	1.0513