Flunarizine hydrochloride

CAS Number: 30484-77-6

Molecular Mass: 477.4 g/mol

Formula: C₂₆H₂₈Cl₂F₂N₂

Smiles: Cl.Cl.Fc1ccc(C(c2ccc(F)cc2)N2CCN(C/C=C/c3ccccc3)CC2)cc1

Synonymes:

Flunarizine hydrochloride, 30484-77-6, flunarizine hydrochloride, Flunarizine HCl, Flunarizine (as hydrochloride), R 14950, R-14950, C11102TO53, NSC-757807, R 14,950, (E)-1-(Bis-(p-fluorophenyl)methyl)-4-cinnamylpiperazine dihydrochloride, DTXSID80184554, Piperazine, 1-(bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)-, dihydrochloride, (E)-, Flurizin, Migarid-10, RefChem:599353, Hydrochloride, Flunarizine, Dihydrochloride, Flunarizine, DTXCID20107045, 250-216-6, Flunarizine dihydrochloride, Flunarizine 2HCl, Flugeral, 27064-95-5, MFCD00058198, 1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine dihydrochloride, (E)-1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine dihydrochloride, Flunarizine (dihydrochloride), 1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine, dihydrochloride, Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]-, hydrochloride (1:2), 1-[BIS(4-FLUOROPHENYL)METHYL]-4-CINNAMYLPIPERAZINE DIHYDROCHLORIDE, (E)-1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine dihydrochloride, C26H28Cl2F2N2, SR-01000000006, EINECS 250-216-6, Flunarizine hydrochloride [USAN:JAN], KW-3149, Dinaplex, UNII-C11102TO53, Prestwick_222, EINECS 248-203-5, Flunarizine dihydroch, Flunarizine * 2HCl, 1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride, (E)-1-(Bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)piperazine dihydrochloride, SPECTRUM1500993, Flunarizine dihydrochloride CRS, CHEMBL552659, HY-B0358AR, orb1310274, SCHEMBL1009444, CHEBI:31621, HY-B0358A, MSK10403A, RXKMOPXNWTYEHI-RDRKJGRWSA-N, GLXC-07363, HMS1568P06, HMS1921O12, HMS3411C08, HMS3675C08, HMS5080H17, Tox21_500527, CCG-39000, s2030, Flunarizine hydrochloride (JAN/USAN), AKOS015895373, Piperazine, 1-(bis(p-fluorophenyl)methyl)-4-cinnamyl-, dihydrochloride, (E)-, AC-2152, EBC-108074, FF23332, FLUNARIZINE HYDROCHLORIDE [JAN], KS-5125, LP00527, NSC 757807, FLUNARIZINE DIHYDROCHLORIDE [MI], FLUNARIZINE HYDROCHLORIDE [USAN], Flunarizine (dihydrochloride) (Standard), FLUNARIZINE HYDROCHLORIDE [MART.], NCGC00093920-01, NCGC00093920-02, NCGC00093920-03, NCGC00261212-01, BF166238, LS-15141, SY108131, FLUNARIZINE DIHYDROCHLORIDE [WHO-DD], Flunarizine dihydrochloride, >=98% (TLC), EU-0100527, NS00076409, ST51015006, SW196530-3, A51066, D01303, F 8257, Flunarizine dihydrochloride - Bio-X trade mark, F862336, FLUNARIZINE DIHYDROCHLORIDE [EP MONOGRAPH], SR-01000000006-2, SR-01000000006-4, SR-01000000006-9, Q27275038, Flunarizine Dihydrochloride 1.0 mg/ml in Methanol (as free base), 1-[bis(4-fluorophenyl)methyl]-4-[(E)-cinnamyl]piperazine, dihydrochloride, Flunarizine dihydrochloride, European Pharmacopoeia (EP) Reference Standard, 1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)-piperazine dihydrochloride, 1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]piperazine hydrochloride, 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine dihydrochloride, 1-[BIS(4-FLUOROPHENYL)METHYL]-4-[(E)-3-PHENYLPROP-2-ENYL]PIPERAZINE 2HCL, 4-((2E)-3-phenylprop-2-enyl)-1-[bis(4-fluorophenyl)methyl]piperazine, chloride , chloride, 1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine--hydrogen chloride (1/2), Flunarizine dihydrochloride for system suitability, European Pharmacopoeia (EP) Reference Standard

Bioactivity: -

Solubility in Different Solvents

Solvent	Temperature [K]	Crystal form	Solubility [mg/mL]	Reference
1-Butanol	293.15	-	9.665	[242]
1-Butanol	298.15	-	12.28	[242]
1-Butanol	303.15	-	15.34	[242]
1-Butanol	308.15	-	19.2	[242]
1-Butanol	313.15	-	23.85	[242]
1-Butanol	318.15	-	29.45	[242]
1-Butanol	323.15	-	36.34	[242]
1-Butanol	328.15	-	44.51	[242]
1-Butanol	333.15	-	54.38	[242]
1-Propanol	293.15	-	30.27	[242]
1-Propanol	298.15	-	37.51	[242]
1-Propanol	303.15	-	45.45	[242]
1-Propanol	308.15	-	55.63	[242]
1-Propanol	313.15	-	68.23	[242]
1-Propanol	318.15	-	81.83	[242]
1-Propanol	323.15	-	98.97	[242]
1-Propanol	328.15	-	118.9	[242]
1-Propanol	333.15	-	140.7	[242]
Acetone	293.15	-	17.65	[242]
Acetone	298.15	-	21.88	[242]
Acetone	303.15	-	27.14	[242]
Acetone	308.15	-	33.1	[242]
Acetone	313.15	-	40.51	[242]
Acetone	318.15	-	49.2	[242]
Acetone	323.15	-	59.47	[242]
Acetone	328.15	-	71.62	[242]
Acetone	333.15	-	86.13	[242]
Acetonitrile	293.15	-	19.97	[242]
Acetonitrile	298.15	-	24.91	[242]
Acetonitrile	303.15	-	30.87	[242]
Acetonitrile	308.15	-	38.28	[242]
Acetonitrile	313.15	-	46.94	[242]
Acetonitrile	318.15	-	57.51	[242]
Acetonitrile	323.15	-	70.0	[242]
Acetonitrile	328.15	-	85.34	[242]
Acetonitrile	333.15	-	103.4	[242]
Ethanol	293.15	-	42.93	[242]
Ethanol	298.15	-	53.17	[242]
Ethanol	303.15	-	64.6	[242]
Ethanol	308.15	-	79.22	[242]
Ethanol	313.15	-	96.61	[242]
Ethanol	318.15	-	116.9	[242]
Ethanol	323.15	-	141.7	[242]
Ethanol	328.15	-	169.6	[242]
Ethanol	333.15	-	202.2	[242]
Ethyl acetate	293.15	-	7.134	[242]
Ethyl acetate	298.15	-	8.934	[242]
Ethyl acetate	303.15	-	11.05	[242]
Ethyl acetate	308.15	-	13.66	[242]
Ethyl acetate	313.15	-	16.81	[242]
Ethyl acetate	318.15	-	20.54	[242]
Ethyl acetate	323.15	-	24.9	[242]
Ethyl acetate	328.15	-	30.09	[242]
Ethyl acetate	333.15	-	36.35	[242]
Isobutanol	293.15	-	9.626	[242]
Isobutanol	298.15	-	12.16	[242]
Isobutanol	303.15	-	15.19	[242]
Isobutanol	308.15	-	18.95	[242]
Isobutanol	313.15	-	23.51	[242]
Isobutanol	318.15	-	29.03	[242]
Isobutanol	323.15	-	35.89	[242]
Isobutanol	328.15	-	43.93	[242]
Isobutanol	333.15	-	53.37	[242]
Isopropanol	293.15	-	16.3	[242]
Isopropanol	298.15	-	20.42	[242]
Isopropanol	303.15	-	25.16	[242]
Isopropanol	308.15	-	30.91	[242]
Isopropanol	313.15	-	37.95	[242]
Isopropanol	318.15	-	46.22	[242]
Isopropanol	323.15	-	55.95	[242]
Isopropanol	328.15	-	67.75	[242]
Isopropanol	333.15	-	82.1	[242]
Methanol	293.15	-	71.62	[242]
Methanol	298.15	-	89.7	[242]
Methanol	303.15	-	109.8	[242]
Methanol	308.15	-	134.9	[242]
Methanol	313.15	-	162.4	[242]
Methanol	318.15	-	197.5	[242]
Methanol	323.15	-	239.8	[242]
Methanol	328.15	-	289.0	[242]
Methanol	333.15	-	344.7	[242]
Methyl acetate	293.15	-	8.012	[242]
Methyl acetate	298.15	-	10.06	[242]
Methyl acetate	303.15	-	12.55	[242]
Methyl acetate	308.15	-	15.54	[242]
Methyl acetate	313.15	-	19.13	[242]
Methyl acetate	318.15	-	23.0	[242]
Methyl acetate	323.15	-	28.62	[242]
Methyl acetate	328.15	-	34.72	[242]
Methyl acetate	333.15	-	42.12	[242]

Molecule 3D descriptors

Descriptor	Value
PMI1	2258.2951
PMI2	8644.1310
PMI3	10102.0089
NPR1	0.2235
NPR2	0.8557
RadiusOfGyration	4.6902
InertialShapeFactor	0.0004
Eccentricity	0.9747
Asphericity	0.4734
SpherocityIndex	0.2279
PBF	1.0850