Lornoxicam

Nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class used for the treatment of pain and inflammation, including inflammatory joint diseases and osteoarthritis. It inhibits COX-1 and COX-2 and thereby reduces prostaglandin production

CAS Number: 70374-39-9

Molecular Mass: 371.8 g/mol

Formula: C₁₃H₁₀ClN₃O₄S₂

Smiles: CN1C(C(=O)Nc2ccccn2)=C(O)c2sc(Cl)cc2S1(=O)=O

Synonymes:

Lornoxicam, 70374-39-9, Chlortenoxicam, Xefocam, Xefo, Lorcam, Lornoxicamum, Ro 13-9297, CCRIS 8589, NSC-759620, Ro-13-9297, ER09126G7A, Ro-139297, 2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXAMIDE, 6-CHLORO-4-HYDROXY-2-METHYL-N-2-PYRIDINYL-, 1,1-DIOXIDE, CHEBI:31783, 2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide, RefChem:800048, M01AC05, 6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-(pyridin-2-yl)-2H-1??-thieno(2,3-e)(1,2)thiazine-3-carboxamide, DTXCID4026133, DTXSID6046133, Lornoxicamum [INN-Latin], Taigalor, Safem, Telos, Lorcam (TN), CLTX, MFCD00866163, C13H10ClN3O4S2, 6-chloro-4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide, Lornoxicam (Xefo), 6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-carboxamide, Chlortenoxicam, Ro 13-9297, TS110, 6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-Dioxide, 6-chloro-4-hydroxy-2-methyl-N-pyridin-2-yl-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide, 70374-27-5, SMR000550483, Lornoxicam [USAN:INN:BAN], BRN 1039965, UNII-ER09126G7A, Lornoxicam (Standard), LORNOXICAM [MI], LORNOXICAM [INN], LORNOXICAM [JAN], LORNOXICAM [USAN], LORNOXICAM [MART.], LORNOXICAM [WHO-DD], SCHEMBL35101, SCHEMBL35102, 6-Chloro-4-hydroxy-2-methyl-N-2-pyridyl-2H-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide, MLS001165721, MLS001304721, MLS006010084, orb1308547, orb3025392, SCHEMBL1650239, SCHEMBL6881779, CHEMBL1569487, CHEMBL3188235, Lornoxicam (JP18/USAN/INN), Lornoxicam, >=98% (HPLC), SCHEMBL29353228, SCHEMBL30649134, BDBM92331, HY-B0367R, HMS2231B07, HMS3264I20, HMS3655N13, HMS3887C17, HMS5087P15, Pharmakon1600-01502302, ALBB-014101, HY-B0367, MSK10340, EBC-03924, NSC759620, s2047, SBB056363, STL504715, TS-110, AKOS000281810, AKOS021982478, AKOS026750113, AB07518, AC-4675, CCG-213023, DB06725, FL24940, KS-1080, NSC 759620, NCGC00246566-01, NCGC00346667-01, NCGC00346667-02, 6-chloro-4-hydroxy-2-methyl-3-(2-pyridylcarbamoyl)-2H-thieno[2,3-e]-1,2-thiazine-1,1-dioxide, HN-10000, SY051041, L0239, NS00004372, SW220125-1, C76243, D01866, SBI-0653409.0001, AB00876293_04, AB00876293_06, EN300-6488763, F069199, SR-01000799148, Q2734874, SR-01000799148-3, Z2235801980, 6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-(2-pyridyl)thieno[2,3-e]thiazine-3-carboxamide, (3E)-6-chloro-3-[hydroxy(pyridin-2-ylamino)methylene]- 2-methyl-2,3-dihydro-4H-thieno[2,3-e][1,2] thiazin- 4 - one 1,1-dioxide, (3e)-6-chloro-3-[hydroxyl(pyridin-2-ylamino)methylene]-2-methyl-2,3-dihydro-4h-thieno[2,3-e][1,2]thiazin-4-one 1,1-dioxide, (6-chloro-4-hydroxy-2-methyl-1,1-dioxothiopheno[2,3-e]1,2-thiazin-3-yl)-N-(2-p yridyl)carboxamide, 2H-Thieno(3,2-e)-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide, 6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-(pyridin-2-yl)-2H-1|E?-thieno[2,3-e][1,2]thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-(pyridin-2-yl)-2H-1lambda6-thieno[2,3-e][1,2]thiazine-3-carboxamide, 6-Chloro-4-hydroxy-2-methyl-N-(2-pyridyl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-Dioxide, 6-chloro-4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide1,1-dioxide, 6-Chloro-4-hydroxy-2-methyl-N-pyridin-2-yl-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide (Lornoxicam), 6-Chloro-4-hydroxy-2-methyl-N-pyridin-2-yl-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide-1,1-dioxide

Bioactivity: COX-1 and COX-2 inhibitor; NSAID

Solubility in Different Solvents

Solvent	Temperature [K]	Crystal form	Solubility [mg/mL]	Reference
1-Butanol	298.15	-	0.05497	[26]
1-Butanol	303.15	-	0.06236	[26]
1-Butanol	308.15	-	0.07007	[26]
1-Butanol	313.15	-	0.0793	[26]
1-Butanol	323.15	-	0.09432	[26]
2-Butanol	298.15	-	0.1203	[26]
2-Butanol	303.15	-	0.1437	[26]
2-Butanol	308.15	-	0.1668	[26]
2-Butanol	313.15	-	0.1893	[26]
2-Butanol	323.15	-	0.2576	[26]
Diethylene Glycol Monoethyl Ether	298.15	-	0.8639	[26]
Diethylene Glycol Monoethyl Ether	303.15	-	1.036	[26]
Diethylene Glycol Monoethyl Ether	308.15	-	1.248	[26]
Diethylene Glycol Monoethyl Ether	313.15	-	1.484	[26]
Diethylene Glycol Monoethyl Ether	323.15	-	1.979	[26]
Ethanol	298.15	-	0.0824	[25]
Ethanol	298.15	-	0.0534	[26]
Ethanol	303.15	-	0.07311	[26]
Ethanol	308.15	-	0.09086	[26]
Ethanol	313.15	-	0.1234	[26]
Ethanol	323.15	-	0.1983	[26]
Ethyl acetate	298.15	-	0.3167	[26]
Ethyl acetate	303.15	-	0.3404	[26]
Ethyl acetate	308.15	-	0.3671	[26]
Ethyl acetate	313.15	-	0.3955	[26]
Ethyl acetate	323.15	-	0.4409	[26]
Ethylene Glycol	298.15	-	1.489	[26]
Ethylene Glycol	303.15	-	2.214	[26]
Ethylene Glycol	308.15	-	3.132	[26]
Ethylene Glycol	313.15	-	4.177	[26]
Ethylene Glycol	323.15	-	7.073	[26]
Isopropanol	298.15	-	0.04373	[26]
Isopropanol	303.15	-	0.05576	[26]
Isopropanol	308.15	-	0.06932	[26]
Isopropanol	313.15	-	0.08602	[26]
Isopropanol	323.15	-	0.1254	[26]
Propylene Glycol	298.15	-	0.16	[26]
Propylene Glycol	303.15	-	0.181	[26]
Propylene Glycol	308.15	-	0.203	[26]
Propylene Glycol	313.15	-	0.225	[26]
Propylene Glycol	323.15	-	0.2677	[26]
Water	298.15	-	0.062	[25]
Water	298.15	-	0.05988	[26]
Water	298.15	-	0.0597	[27]
Water	303.15	-	0.08466	[26]
Water	303.15	-	0.0845	[27]
Water	308.15	-	0.1132	[26]
Water	308.15	-	0.1153	[27]
Water	313.15	-	0.1489	[26]
Water	313.15	-	0.1517	[27]
Water	323.15	-	0.2427	[26]
Water	323.15	-	0.245	[27]

Molecule 3D descriptors

Descriptor	Value
PMI1	946.5197
PMI2	5084.1112
PMI3	5712.6351
NPR1	0.1657
NPR2	0.8900
RadiusOfGyration	3.9738
InertialShapeFactor	0.0009
Eccentricity	0.9862
Asphericity	0.5835
SpherocityIndex	0.1307
PBF	0.6795