Donepezil hydrochloride

Reversible acetylcholinesterase inhibitor used for the symptomatic treatment of dementia associated with Alzheimer's disease. It inhibits acetylcholinesterase, increasing acetylcholine concentrations in the central nervous system and enhancing cholinergic neurotransmission

CAS Number: 120011-70-3

Molecular Mass: 416.0 g/mol

Formula: C₂₄H₃₀ClNO₃

Smiles: COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2.Cl

Synonymes:

Donepezil hydrochloride, 120011-70-3, Donepezil HCl, BNAG, Aricept ODT, E-2020, E2020, ADLARITY, Aricept Evess, NSC-737535, NSC-758882, 3O2T2PJ89D, DTXSID0046698, 1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine hcl, DTXCID8026698, NAMZARIC COMPONENT DONEPEZIL HYDROCHLORIDE, Donepezil Hyrochloride, RefChem:56499, Donepezil Hyrochloride 5mg, Donepezil Hydrochloride 10mg, Donepezil Hydrochloride 5 mg, CHEBI:4696, 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine hydrochloride, (2RS)-2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one monohydrochloride, Aricept, 110119-84-1, 2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one hydrochloride, E 2020, MFCD00881312, 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride, C24H30ClNO3, Donepezil (Hydrochloride), 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride (1:1), CHEMBL1678, 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one, hydrochloride, 1-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine hydrochloride, E2020, E-2020, 2-(1-Benzyl-4-piperidylmethyl)-5,6-dimethoxy-1-indanone Hydrochloride, 2-(1-Benzyl-piperidin-4-ylmethyl)-5,6-dimethoxy-indan-1-one hydrochloride, 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one hydrochloride, E 2020 (pharmaceutical), 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-, hydrochloride, SMR000449292, CAS-120011-70-3, Donepezil hydrochloride [USAN], NSC 737535, NSC 758882, NCGC00167537-01, UNII-3O2T2PJ89D, Memorit, Eranz, Memac, Donepezil,HCl, Aricept D, 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride, Donepezil Hydrochloride, 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride (9CI), Aricept, Aricept D, BNAG, E 2020, Aricept (TN), Donepezil hydrochloride [USAN:USP], Donepezil hydrochloride?, Donepezil HCl (Aricept), 120011-70-3 (HCl), Donepezil hydrochloride CRS, SCHEMBL1815, MLS000758276, MLS001401387, orb1300734, SCHEMBL29424585, HY-B0034R, MSK11214A, XWAIAVWHZJNZQQ-UHFFFAOYSA-N, GLXC-05176, Pharmakon1600-01504403, Donepezil HCl - Bio-X trade mark, HY-B0034, DONEPEZIL HYDROCHLORIDE [MI], Tox21_112534, AC-913, Donepezil hydrochloride (JP18/USP), DONEPEZIL HYDROCHLORIDE [JAN], EBC-70037, HB2083, NSC737535, NSC758882, s2462, Donepezil (Hydrochloride) (Standard), AKOS000277343, AKOS016340656, Tox21_112534_1, CCG-101043, CCG-213309, CS-0863, DONEPEZIL HYDROCHLORIDE [MART.], DONEPEZIL HYDROCHLORIDE [VANDF], FD29053, KS-1051, NC00293, (+-)-2-((1-Benzyl-4-piperidyl)methyl)-5,6-dimethoxy-1-indanone hydrochloride, 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one hydrochloride, DONEPEZIL HYDROCHLORIDE [USP-RS], DONEPEZIL HYDROCHLORIDE [WHO-DD], NCGC00167537-02, BD164380, D4099, DONEPEZIL HYDROCHLORIDE [ORANGE BOOK], DONEPEZIL HYDROCHLORIDE [EP MONOGRAPH], D00670, DONEPEZIL HYDROCHLORIDE [USP MONOGRAPH], E-2022, EN300-269733, F036568, Donepezil hydrochloride monohydrate, >=98% (HPLC), Q27106438, Donepezil Hydrochloride 1.0 mg/ml in Methanol (as free base), 2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-indan-1-one, hydrochloride, (+/-)-2-((1-BENZYL-4-PIPERIDYL)METHYL)-5,6-DIMETHOXY-1-INDANONE HYDROCHLORIDE, 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]-1H-inden-1-one, ( inverted exclamation markA)-2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-1-indanone hydrochloride, (+-)-2,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride, 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochlorideDonepezil Hcl, 2-[(1-Benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one--hydrogen chloride (1/1)

Bioactivity: Acetylcholinesterase (AChE) inhibitor; anti-dementia agent

Solubility in Different Solvents

Solvent	Temperature [K]	Crystal form	Solubility [mg/mL]	Reference
1-Propanol	278.15	-	0.6327	[28]
1-Propanol	283.15	-	0.86	[28]
1-Propanol	288.15	-	1.196	[28]
1-Propanol	293.15	-	1.675	[28]
1-Propanol	298.15	-	2.237	[28]
1-Propanol	303.15	-	2.992	[28]
1-Propanol	308.15	-	4.074	[28]
1-Propanol	313.15	-	5.544	[28]
1-Propanol	318.15	-	7.243	[28]
1-Propanol	323.15	-	9.714	[28]
1-Propanol	328.15	-	12.97	[28]
1-Propanol	333.15	-	17.2	[28]
Dimethylformamide	278.15	-	6.554	[28]
Dimethylformamide	283.15	-	7.391	[28]
Dimethylformamide	288.15	-	8.284	[28]
Dimethylformamide	293.15	-	9.347	[28]
Dimethylformamide	298.15	-	10.55	[28]
Dimethylformamide	303.15	-	11.87	[28]
Dimethylformamide	308.15	-	13.41	[28]
Dimethylformamide	313.15	-	15.15	[28]
Dimethylformamide	318.15	-	17.17	[28]
Dimethylformamide	323.15	-	19.33	[28]
Dimethylformamide	328.15	-	21.87	[28]
Dimethylformamide	333.15	-	24.79	[28]
Ethanol	278.15	-	2.11	[28]
Ethanol	283.15	-	2.731	[28]
Ethanol	288.15	-	3.469	[28]
Ethanol	293.15	-	4.345	[28]
Ethanol	298.15	-	5.451	[28]
Ethanol	303.15	-	6.712	[28]
Ethanol	308.15	-	8.255	[28]
Ethanol	313.15	-	10.1	[28]
Ethanol	318.15	-	12.27	[28]
Ethanol	323.15	-	14.82	[28]
Ethanol	328.15	-	17.81	[28]
Ethanol	333.15	-	21.05	[28]
Methanol	278.15	-	17.5	[28]
Methanol	283.15	-	23.1	[28]
Methanol	288.15	-	29.74	[28]
Methanol	293.15	-	38.62	[28]
Methanol	298.15	-	49.51	[28]
Methanol	303.15	-	64.92	[28]
Methanol	308.15	-	81.66	[28]
Methanol	313.15	-	105.9	[28]
Methanol	318.15	-	134.3	[28]
Methanol	323.15	-	171.2	[28]
Methanol	328.15	-	217.7	[28]
Methanol	333.15	-	278.6	[28]

Molecule 3D descriptors

Descriptor	Value
PMI1	1141.3982
PMI2	9550.1763
PMI3	10277.2587
NPR1	0.1111
NPR2	0.9293
RadiusOfGyration	5.0205
InertialShapeFactor	0.0008
Eccentricity	0.9938
Asphericity	0.7037
SpherocityIndex	0.1096
PBF	0.8026