Telmisartan

Angiotensin II receptor blocker (ARB) used primarily for the treatment of hypertension and reduction of cardiovascular risk. Telmisartan selectively antagonizes angiotensin II type 1 (AT1) receptors, thereby reducing angiotensin II-mediated vasoconstriction and aldosterone secretion

CAS Number: 144701-48-4

Molecular Mass: 514.6 g/mol

Formula: C₃₃H₃₀N₄O₂

Smiles: CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1

Synonymes:

Telmisartan, 144701-48-4, Micardis, Pritor, Kinzalmono, BIBR 277, Semintra, BIBR-277, tolura, Telmisartan Teva, Telmisartan Actavis, BIBR-277-SE, BIBR-277SE, BIBR 277 SE, [1,1'-Biphenyl]-2-carboxylic acid, 4'-[(1,4'-dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-, 4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carboxylic acid, U5SYW473RQ, BIBR-277 SE, DTXSID8023636, C09CA07, 4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid, 4'-((4-Methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl)methyl)-2-biphenylcarboxylic acid, TELMISARTAN TEVA PHARMA, 2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid, CHEBI:9434, DTXCID803636, ONDUARP COMPONENT TELMISARTAN, TOLUCOMBI COMPONENT TELMISARTAN, KINZALKOMB COMPONENT TELMISARTAN, PRITORPLUS COMPONENT TELMISARTAN, (1,1'-Biphenyl)-2-carboxylic acid, 4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-, MICARDISPLUS COMPONENT TELMISARTAN, 4'-[(1,4'-dimethyl-2'propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid, 2-(4-{[4-methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}phenyl)benzoic acid, 4'-[[4-METHYL-6-(1-METHYL-2-BENZIMIDAZOLYL)-2-PROPYL-1-BENZIMIDAZOLYL]METHYL]-2-BIPHENYLCARBOXYLIC ACID, telmisartanum, 2-(4-((4-methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl)methyl)phenyl)benzoic acid, 2-(4-((4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl)methyl)phenyl)benzoic acid, 4'-((1,4'-dimethyl-2'propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid, 4'-((1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl)biphenyl-2-carboxylic acid, 4'-((4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl)methyl)biphenyl-2-carboxylic acid, 4'-[[4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic Acid, RefChem:6287, 620-494-7, 4'-((1,7'-Dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid, BIBR 277SE, Telmisartan [INN], C33H30N4O2, MFCD00918125, CHEMBL1017, 4'-[(1,4'-dimethyl-2'-propyl[2,6'-bi-1h-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid, NCGC00095150-01, Targit, 2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propyl-benzimidazol-1-yl]methyl]phenyl]benzoic acid, 4'[(1,4'-DIMETHYL-2'-PROPYL[2,6'-BI-1H-BENZIMIDAZOL]-1'-YL)METHYL][1,1'-BIPHENYL]-2-CARBOXYLIC ACID, Kinzal, Tazlok, Kinzal/Pritor, Micardis (TN), 4'-(1,7'-DIMETHYL-2'-PROPYL-1H-[2,5']BIBENZOIMIDAZOLYL-3'-YLMETHYL)-BIPHENYL-2-CARBOXYLIC ACID, SMR000466326, CAS-144701-48-4, Bay 68-9291, SR-01000759355, UNII-U5SYW473RQ, Telmisartana, Telmisartar, Telmisatran, BIBR277, Telsite, Telday, Telmisartan CRS, Kinzal, , Pritor, , HSDB 7590, Telma, , Teleact D, , Telmisartan [USAN:USP:INN:BAN], YM-086, BAY68-9291, Telmisartan (Micardis), Telmisartan (Standard), CPD000466326, TELMISARTAN [MI], Spectrum2_001976, Spectrum3_001089, Spectrum4_001261, Spectrum5_001053, TELMISARTAN [JAN], TELMISARTAN [HSDB], TELMISARTAN [USAN], TELMISARTAN [VANDF], SCHEMBL4464, TELMISARTAN [MART.], BSPBio_002738, GTPL592, KBioGR_001842, TELMISARTAN [USP-RS], TELMISARTAN [WHO-DD], MLS000759432, MLS001076687, MLS001424174, MLS006011851, Widaplik component Telmisartan, BIDD:GT0365, SPECTRUM1505261, SPBio_002131, TELMISARTAN [EMA EPAR], orb1308143, Telmisartan (JP17/USP/INN), SCHEMBL29356790, SCHEMBL29414101, SCHEMBL29691699, Telmisartan - Bio-X trade mark, TELMISARTAN [GREEN BOOK], KBio3_001958, TELMISARTAN [EP IMPURITY], TELMISARTAN [ORANGE BOOK], RMMXLENWKUUMAY-UHFFFAOYSA-N, GLXC-02564, HMS1922P07, HMS2051P16, HMS2090P17, HMS2093M22, HMS2231P07, HMS3393P16, HMS3655C08, HMS3715L17, HMS3750E19, HMS5079L20, Pharmakon1600-01505261, TELMISARTAN [EP MONOGRAPH], TELMISARTAN [USP MONOGRAPH], ALBB-028954, MSK10070, TWYNSTA COMPONENT TELMISARTAN, Tox21_111452, BBL029085, BDBM50043280, CCG-39514, DL-511, EBC-02079, HB2558, HY-13955R, NSC759811, s1738, STK624049, AKOS005557501, Telmisartan for system suitability CRS, Telmisartan, >=98% (HPLC), solid, Tox21_111452_1, AB07687, AC-2013, CS-1699, DB00966, FT15497, KS-1215, NC00296, NSC 759811, NSC-759811, Telmisartan for peak identification CRS, BAY-68-9291, MICARDIS HCT COMPONENT TELMISARTAN, NCGC00095150-02, NCGC00095150-03, NCGC00095150-04, NCGC00095150-06, NCGC00095150-07, NCGC00095150-08, TELMISARTAN [EMA EPAR VETERINARY], 4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid, 4'-{[4-methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}-[1,1'-biphenyl]-2-carboxylic acid, BT164444, HY-13955, SY052776, SBI-0206733.P001, NS00000398, SW197676-3, C07710, D00627, EN300-123532, AB00639941-06, AB00639941-07, AB00639941_08, AB00639941_09, L001035, Q733186, SR-01000759355-4, SR-01000759355-5, BRD-K73999723-001-02-2, BRD-K73999723-001-10-5, BRD-K73999723-001-11-3, Z1551967334, Telmisartan, European Pharmacopoeia (EP) Reference Standard, Telmisartan, United States Pharmacopeia (USP) Reference Standard, Telmisartan, Pharmaceutical Secondary Standard, Certified Reference Material, Telmisartan for peak identification, European Pharmacopoeia (EP) Reference Standard, Telmisartan for system suitability, European Pharmacopoeia (EP) Reference Standard, 2-(4-{[4-Methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl] methyl}phenyl)benzoic acid, 4''-((1,4''-dimethyl-2''-propyl(2,6''-bi-1H-benzimidazol)-1''-yl)methyl)-(1,1''-biphenyl)-2-carboxylic acid, 4''-((4-methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl)methyl)-2-biphenylcarboxylic acid, 4''-[(1,4''-dimethyl-2''propyl[2,6''-bi-1H-benzimidazol]-1''-yl)methyl]-[1,1''-biphenyl]-2-carboxylic acid, 4''-[(1,7''-dimethyl-2''-propyl-1H,3''H-2,5''-bibenzimidazol-3''-yl)methyl][1,1''-biphenyl]-2-carboxylic acid, 4''-[(1,7''-dimethyl-2''-propyl-1H,3''H-2,5''-bibenzimidazol-3''-yl)methyl]biphenyl-2-carboxylic acid, 4'-((1,7'-Dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylicacid, 4'-((1,7'-DIMETHYL-2'-PROPYL-1H,3'H-2,5'-BIBENZO[D]IMIDAZOL-3'-YL)METHYL)BIPHENYL-2-CARBOXYLIC ACID, 4'-[(1,7'-Dimethyl-2'-propyl-1H,3'H-[2,5'-bi-1,3-benzimidazol]-3'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid, 4'-[[2-n-Propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid, 4'-[2-n-propyl-4-methyl-6-(1-methyl benzimidazol-2-yl)benzimidazol-1-yl methyl]biphenyl-2-carboxylic acid, TLS

Bioactivity: Angiotensin II AT1 receptor antagonist; antihypertensive agent

Solubility in Different Solvents

Solvent	Temperature [K]	Crystal form	Solubility [mg/mL]	Reference
Acetone	278.55	-	0.3162	[29]
Acetone	287.45	-	0.4033	[29]
Acetone	294.55	-	0.5424	[29]
Acetone	303.85	-	0.6516	[29]
Acetone	308.75	-	0.7667	[29]
Acetone	316.25	-	0.9545	[29]
Acetone	325.75	-	1.288	[29]
Benzene	278.55	-	0.4095	[29]
Benzene	288.45	-	0.6464	[29]
Benzene	299.85	-	0.9363	[29]
Benzene	307.25	-	1.344	[29]
Benzene	316.15	-	1.627	[29]
Benzene	324.35	-	2.012	[29]
Benzene	333.35	-	2.69	[29]
Chloroform	278.75	-	35.01	[29]
Chloroform	289.45	-	40.47	[29]
Chloroform	296.95	-	45.07	[29]
Chloroform	298.15	-	46.55	[29]
Chloroform	303.95	-	47.61	[29]
Chloroform	308.35	-	48.87	[29]
Chloroform	313.15	-	50.34	[29]
Dichloromethane	278.35	-	12.3	[29]
Dichloromethane	286.55	-	14.37	[29]
Dichloromethane	293.95	-	16.48	[29]
Dichloromethane	298.05	-	17.27	[29]
Dichloromethane	305.25	-	19.47	[29]
Dichloromethane	308.35	-	20.57	[29]
Dichloromethane	311.75	-	21.33	[29]
Ethanol	277.85	-	0.2744	[29]
Ethanol	288.45	-	0.4052	[29]
Ethanol	298.45	-	0.555	[29]
Ethanol	308.35	-	0.7804	[29]
Ethanol	313.45	-	1.009	[29]
Ethanol	329.75	-	1.854	[29]
Ethanol	333.65	-	2.149	[29]
Ethyl acetate	283.65	-	0.1316	[29]
Ethyl acetate	293.35	-	0.2193	[29]
Ethyl acetate	303.65	-	0.306	[29]
Ethyl acetate	305.35	-	0.3238	[29]
Ethyl acetate	317.95	-	0.4487	[29]
Ethyl acetate	329.45	-	0.6148	[29]
Ethyl acetate	333.65	-	0.7353	[29]
Isopropanol	288.45	-	0.1048	[29]
Isopropanol	298.05	-	0.1853	[29]
Isopropanol	309.55	-	0.271	[29]
Isopropanol	316.55	-	0.3682	[29]
Isopropanol	321.55	-	0.4828	[29]
Isopropanol	329.55	-	0.6843	[29]
Isopropanol	338.35	-	1.003	[29]
Methanol	278.45	-	0.7796	[29]
Methanol	288.55	-	1.14	[29]
Methanol	299.85	-	1.664	[29]
Methanol	307.35	-	1.911	[29]
Methanol	313.25	-	2.307	[29]
Methanol	324.85	-	3.313	[29]
Methanol	330.05	-	3.826	[29]
Toluene	278.65	-	0.1746	[29]
Toluene	288.45	-	0.2959	[29]
Toluene	300.05	-	0.4037	[29]
Toluene	306.35	-	0.5966	[29]
Toluene	316.75	-	0.7975	[29]
Toluene	325.85	-	1.051	[29]
Toluene	334.55	-	1.42	[29]

Molecule 3D descriptors

Descriptor	Value
PMI1	4697.8444
PMI2	11219.6325
PMI3	14083.3642
NPR1	0.3336
NPR2	0.7967
RadiusOfGyration	5.3989
InertialShapeFactor	0.0002
Eccentricity	0.9427
Asphericity	0.3085
SpherocityIndex	0.2539
PBF	1.3382