Loratadine
CAS Number: 79794-75-5
Molecular Mass: 382.9 g/mol
Formula: C22H23ClN2O2
Smiles: CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1
Synonymes:
Loratadine, loratadine, 79794-75-5, Claritin, Alavert, Clarityn, Clarityne, Lisino, Fristamin, Loracert, Loradex, Bonalerg, Claritine, Histaloran, Lertamine, Lorastine, Loratyne, Civeran, Loranox, Claritin Reditabs, Aerotina, Alerpriv, Anhissen, Claratyne, Loratadina, Loritine, Restamine, Sensibit, Biloina, Nularef, Sch 29851, Sch-29851, Loratadine Redidose, Children's Claritin, Loratadinum, Roletra, Claritin Hives Relief, Claritin Hives Relief Reditab, NSC-758628, Clarityn rapide, Hay-rite, 7AJO3BO7QN, BAY76-2211, Topcare childrens allergy relief, DTXSID2023224, Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylate, CHEBI:6538, DTXCID903224, ethyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate, NSC721075, ethyl 4-(8-chloro-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-11-ylidene)piperidine-1-carboxylate, Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate, ethyl 4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene}piperidine-1-carboxylate, Allervarx, HealthMart, Sch29851, Alavert Allergy, Loratadine Oral, Claritin Allergy, Loratadine OD, loratadine tablet, Wal-itin, Loratadine ODT, Children Claritin, Childrens Allergy, Childrens Walitin, Claritin Chewable, Leader Loratadine, Loratadine 10mg, Medique Loradamed, Wal Itin, AlloPAX, Counteract Allergy, Loratadine Tablets, Claritin, BSX, Claritin, CVP, Hy-Vee, Childrens Wal-itin, Guardian Loratadine, Loratadine 10 mg, McKesson Loratadine, ethyl 4-(13-chloro-4-azatricyclo(9.4.0.0^(3,8))pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate, ethyl 4-(13-chloro-4-azatricyclo(9.4.0.03,8)pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate, ethyl 4-(8-chloro-5,6-dihydrobenzo(1,2)cyclohepta(2,4-b)pyridin-11-ylidene)piperidine-1-carboxylate, Claritin Liqui-gels, Childrens Loratadine, XL-3 Allergy, CAREALL Loratadine, Childrens Non-Drowsy, Loratadine Non drowsy, Curist Allergy Relief, Equate Allergy Relief, Leader Allergy Relief, Loratadineantihistamine, Rexall Allergy Relief, Careone Allergy Relief, Health Mart Loratadine, Live Better Loratadine, Topcare Allergy Relief, Help I Have Allergies, Equaline Allergy Relief, Loratadine Antihistamine, RefChem:5961, Sunmark Loratadine ODT, All Day Allergy Relief, equate childrens allergy, Members Mark Aller-itin, Wal-itin Allergy Relief, Allergy Relief Childrens, Childrens Allergy Relief, Lil Drug Store Claritin, CAREALL Allergy Relief, non drowsy allergy relief, Children Claritin Allergy, Childrens Loratadine Oral, Dg Health Allergy Relief, Loratadine Allergy Relief, Topcare Childrens Allergy, Healthmart Loratadine ODT, LORATADINE SOFTGELS, caring mill allergy relief, Allergy Relief Non Drowsy, Basic Care Allergy Relief, Good Sense Allergy Relief, Non-Drowsy Allergy Relief, Sound Body Allergy Relief, Up and Up Allergy Relief, ALLERGY RELIEF 10mg, dg health childrens allergy, Hy-vee Childrens Loratadine, up and up childrens allergy, Members Mark Allergy Relief, Sunmark Childrens Loratadine, Topcare Childrens Loratadine, childrens allergy Sugar Free, welby all day allergy relief, ALLERGY RELIEF 10 mg, Equaline Childrens Loratadine, Kirkland Signature Allerclear, 4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester, Care One Childrens Loratadine, Dye-Free Childrens Loratadine, Indoor Outdoor Allergy Relief, Signature Care Allergy Relief, Exchange Select Allergy Relief, Medi-First Plus Allery Relief, Welby Childrens Allergy Relief, CHILDRENS LORATADINE ODT, Healthmart Childrens Loratadine, Childrens Loratadine Sugar Free, Curist Childrens Allergy Relief, Equate Childrens Allergy Relief, Good Sense Childrens Loratadine, Leader Childrens Allergy Relief, Medi First Plus Allergy Relief, Best Choice Childrens Loratadine, Careone Allergy Relief 24 Hour, First Aid Direct Allergy Relief, Topcare Allergy Relief 24 Hour, CareOne Childrens Allergy Relief, Foster and Thrive Allergy Relief, loratadine 5 mg chewable tablets, Loratadine Tablets USP, 10 mg, Equaline Childrens Allergy Relief, Good Neighbor Pharmacy Loratadine, Handy Solutions 24 Hour Allergy, R06AX13, Rexall Allergy Relief Non Drowsy, Berkley and Jensen Allergy Relief, dg health childrens allergy relief, Meijer Childrens 24 Hour Allergy, Premier Value Childrens Loratadine, Claritin Chewable Cool Mint Flavor, Good Sense childrens allergy relief, Basic Care Childrens Allergy Relief, Loratadineantihistamine Antihistamine, Up and Up Childrens Allergy Relief, Claritin Chewable Grape and Bubblegum, Claritin, BSX Non-Drowsy, 24 Hour, Claritin, CVP Non-Drowsy, 24 Hour, LORATADINE ALLERGY RELIEF 10mg, AMAZON BASIC CARE ALLERGY RELIEF, Non-Drowsy Allergy Relief, 24-7 Life, Quality Choice Childrens Allergy Relief, Western Family Childrens Allergy Relief, 24 / 7 Life Non-Drowsy Allergy Relief, Medicine Shoppe Loratadine Allergy Relief, Foster and Thrive Childrens Allergy Relief, Berkley and Jensen Childrens Allergy Relief, Best Choice Childrens Loratadine Sugar Free, Good Neighbor Pharmacy Childrens Loratadine, Childrens Non-drowsy 24-hour Allergy Relief, Childrens Non-drowsy Allergy Relief 24-hour, Lil Drug Store Claritin Non-Drowsy, 24 Hour, Levocetirizine dihydrochloride 5%, Loratadine 5%, SUNMARK CHILDRENS LORATADINE SRP SF GRAPE, 616-734-5, Lomilan, Loratidine, Versal, ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate, MFCD00672869, 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester, Loratadine-d4, Allertidin, Polaratyne, Lesidas, Loradif, Lorantis, Loraver, Lorfast, Lowadina, Optimin, Sanelor, Sohotin, Velodan, Lergy, Pylor, Tadine, CHEMBL998, Zeos, Sinhistan Dy, Bedix Loratadina, Talorat Dy, Clarinase Reperabs, MLS000069647, 1-Piperidinecarboxylic acid,4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester, Loratadinum [Latin], Claritin reditab, Loratadina [Spanish], Clarityne-D, NCGC00015619-09, SMR000058255, Clarityne Dy Repetabs, 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester, ethyl 4-(8-chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)piperidine-1-carboxylate, Bactimicina allergy, Claritin (TN), CAS-79794-75-5, HSDB 3578, SR-01000075968, UNII-7AJO3BO7QN, Cronopen, Flonidan, Klaritin, Loratadine, , Claritine, , Clarityne, , Claritin, , Clarityn, , Loratadine CRS, loratadine-form1, Claritin-D, , LoratadineI-p25, Loratadine [USAN:USP:INN:BAN], loratadine-form2-He, Loratadine (Standard), Spectrum_001496, Tocris-1944, LORATADINE [MI], Children''''s claritin, LORATADINE [INN], LORATADINE [JAN], LoratadineI-0deg(L13), Opera_ID_1868, Spectrum2_001584, Spectrum3_000740, Spectrum4_000177, Spectrum5_001650, Lopac-L-9664, LORATADINE [HSDB], LORATADINE [USAN], LoratadineI-p80(L13), LORATADINE [VANDF], L 9664, LORATADINE [MART.], LoratadineI-m100(L13), LoratadineI-m173(L13), SCHEMBL4596, Loratadine Impurity Standard, LORATADINE [USP-RS], LORATADINE [WHO-DD], Lopac0_000680, Oprea1_027965, REGID_for_CID_3957, BSPBio_002300, KBioGR_000693, KBioSS_001976, Loratadine (JAN/USP/INN), MLS000758260, MLS001148466, MLS001423984, BIDD:GT0198, DivK1c_000792, SPECTRUM1503712, SPBio_001548, GTPL7216, Loratadine - Bio-X trade mark, orb1309786, LORATADINE [EP IMPURITY], LORATADINE [ORANGE BOOK], SCHEMBL29380223, SCHEMBL29441811, BDBM22876, HMS502H14, KBio1_000792, KBio2_001976, KBio2_004544, KBio2_007112, KBio3_001520, LORATADINE [EP MONOGRAPH], NINDS_000792, GLXC-08101, HMS2051G11, HMS2090O18, HMS2093I15, HMS2235G23, HMS3262G21, HMS3268M16, HMS3371D13, HMS3393G11, HMS3412N06, HMS3654L17, HMS3676N06, HMS3714E09, HMS5079B15, LORATADINE [USP MONOGRAPH], Pharmakon1600-01503712, Loratadine 0.1 mg/ml in Methanol, GQA72727, MSK10120, Tox21_110185, Tox21_301532, Tox21_500680, BBL010757, BDBM50637414, CCG-39362, DL-436, EBC-11203, HY-17043R, NSC758628, s1358, STK574925, Loratadine for system suitability CRS, AKOS005499513, CLARITIN-D COMPONENT LORATADINE, Loratadine, >=98% (HPLC), powder, Tox21_110185_1, AB06849, AC-2086, CCG-100786, CS-0887, DB00455, FL24933, KS-1079, LP00680, NC00036, NSC 721075, NSC 758628, NSC-721075, SDCCGSBI-0050659.P004, IDI1_000792, Loratadine, Desloratadine EP Impurity C, NCGC00015619-01, NCGC00015619-02, NCGC00015619-03, NCGC00015619-04, NCGC00015619-05, NCGC00015619-06, NCGC00015619-07, NCGC00015619-08, NCGC00015619-10, NCGC00015619-11, NCGC00015619-12, NCGC00015619-13, NCGC00015619-26, NCGC00023125-02, NCGC00023125-04, NCGC00023125-05, NCGC00023125-06, NCGC00023125-07, NCGC00255171-01, NCGC00261365-01, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cycloheptal[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester, BL164637, HY-17043, LORATADINE COMPONENT OF CLARITIN-D, NCI60_041473, SY052751, SBI-0050659.P003, EU-0100680, L0223, NS00002063, SW197416-3, D00364, EN300-119520, AB00053224-15, AB00053224-16, AB00053224_17, AB00053224_18, F793544, L000667, Q424049, SR-01000075968-1, SR-01000075968-3, SR-01000075968-4, SR-01000075968-6, BRD-K82795137-001-02-3, BRD-K82795137-001-10-6, BRD-K82795137-001-24-7, BRD-K82795137-001-25-4, BRD-K82795137-001-26-2, F2173-0505, Z1521553845, Loratadine, British Pharmacopoeia (BP) Reference Standard, Loratadine, European Pharmacopoeia (EP) Reference Standard, Loratadine, United States Pharmacopeia (USP) Reference Standard, Loratadine, Pharmaceutical Secondary Standard, Certified Reference Material, Loratadine for system suitability, European Pharmacopoeia (EP) Reference Standard, 1-Piperidenecarboxylic acid,6-duhydro-11H-benzo [5,6]cyclohepta[1,2-b]-pyridin-11-ylidene)-, ethyl ester, 11-[N-(ethoxycarbonyl)-4-piperidylidene]-8-chloro-6,11-dihydro-5H-benzo-[5,6]cyclohepta[1,2-b]pyridine, 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester, 4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidine-1-carboxylic acid ethyl ester, 4-(8-chloro-5,6-dihydrobenzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylic acid ethyl ester, 8-chloro-11-(1-ethoxycarbonyl-4-piperidylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-6,11-dihydro-11-(1- ethoxycarbonyl-4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, 8-Chloro-6,11-dihydro-11-(1-ethoxycarbonyl-4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidine)-1-piperidinecarboxylate, ethyl 4-(8-chloro-5,6-dihydrobenzo[1,2]cyclohepta[3,4-b]pyridin-11-ylidene)piperidine-1-carboxylate, ethyl 4-{13-chloro-4-azatricyclo[9.4.0.0(3),]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene}piperidine-1-carboxylate, ethyl 4-{13-chloro-4-azatricyclo[9.4.0.0,3,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene}piperidine-1-carboxylate
Bioactivity: -
Solubility in Different Solvents
| Solvent | Temperature [K] | Crystal form | Solubility [mg/mL] | Reference |
|---|---|---|---|---|
| 1-Butanol | 283.15 | - | 91.93 | [363] |
| 1-Butanol | 288.13 | - | 116.1 | [363] |
| 1-Butanol | 293.15 | - | 143.9 | [363] |
| 1-Butanol | 298.17 | - | 180.7 | [363] |
| 1-Butanol | 303.15 | - | 229.6 | [363] |
| 1-Butanol | 308.15 | - | 288.3 | [363] |
| 1-Butanol | 313.15 | - | 355.7 | [363] |
| 1-Butanol | 318.12 | - | 434.5 | [363] |
| 1-Butanol | 323.15 | - | 530.7 | [363] |
| 1-Pentanol | 283.12 | - | 82.0 | [363] |
| 1-Pentanol | 288.15 | - | 104.5 | [363] |
| 1-Pentanol | 293.13 | - | 131.2 | [363] |
| 1-Pentanol | 298.15 | - | 164.7 | [363] |
| 1-Pentanol | 303.15 | - | 207.8 | [363] |
| 1-Pentanol | 308.13 | - | 255.9 | [363] |
| 1-Pentanol | 313.15 | - | 313.4 | [363] |
| 1-Pentanol | 318.17 | - | 393.8 | [363] |
| 1-Pentanol | 323.15 | - | 479.3 | [363] |
| 1-Propanol | 283.16 | - | 95.14 | [363] |
| 1-Propanol | 288.12 | - | 125.9 | [363] |
| 1-Propanol | 293.15 | - | 164.2 | [363] |
| 1-Propanol | 298.17 | - | 205.6 | [363] |
| 1-Propanol | 303.15 | - | 252.2 | [363] |
| 1-Propanol | 308.16 | - | 309.3 | [363] |
| 1-Propanol | 313.13 | - | 392.0 | [363] |
| 1-Propanol | 318.15 | - | 500.8 | [363] |
| 1-Propanol | 323.17 | - | 625.6 | [363] |
| Acetone | 283.15 | - | 68.01 | [363] |
| Acetone | 288.13 | - | 81.89 | [363] |
| Acetone | 293.15 | - | 99.59 | [363] |
| Acetone | 298.15 | - | 121.3 | [363] |
| Acetone | 303.15 | - | 148.1 | [363] |
| Acetone | 308.15 | - | 184.3 | [363] |
| Acetone | 313.15 | - | 231.7 | [363] |
| Acetone | 318.17 | - | 292.7 | [363] |
| Acetone | 323.15 | - | 368.9 | [363] |
| Acetonitrile | 283.2 | - | 22.27 | [363] |
| Acetonitrile | 288.25 | - | 28.34 | [363] |
| Acetonitrile | 293.15 | - | 34.96 | [363] |
| Acetonitrile | 298.15 | - | 42.61 | [363] |
| Acetonitrile | 303.15 | - | 54.18 | [363] |
| Acetonitrile | 308.75 | - | 68.94 | [363] |
| Acetonitrile | 313.15 | - | 86.8 | [363] |
| Acetonitrile | 318.15 | - | 111.3 | [363] |
| Acetonitrile | 323.19 | - | 146.3 | [363] |
| Dimethylformamide | 283.11 | - | 107.1 | [363] |
| Dimethylformamide | 288.15 | - | 133.6 | [363] |
| Dimethylformamide | 293.15 | - | 160.1 | [363] |
| Dimethylformamide | 298.15 | - | 200.1 | [363] |
| Dimethylformamide | 303.15 | - | 244.6 | [363] |
| Dimethylformamide | 308.19 | - | 293.8 | [363] |
| Dimethylformamide | 313.15 | - | 357.5 | [363] |
| Dimethylformamide | 318.17 | - | 435.6 | [363] |
| Dimethylformamide | 323.15 | - | 534.8 | [363] |
| Ethanol | 283.15 | - | 79.84 | [363] |
| Ethanol | 288.45 | - | 100.8 | [363] |
| Ethanol | 293.44 | - | 124.1 | [363] |
| Ethanol | 298.15 | - | 155.0 | [363] |
| Ethanol | 303.15 | - | 195.0 | [363] |
| Ethanol | 308.15 | - | 252.3 | [363] |
| Ethanol | 313.54 | - | 330.1 | [363] |
| Ethanol | 318.37 | - | 433.3 | [363] |
| Ethanol | 323.15 | - | 566.3 | [363] |
| Ethyl acetate | 283.15 | - | 70.87 | [363] |
| Ethyl acetate | 288.15 | - | 83.72 | [363] |
| Ethyl acetate | 293.15 | - | 98.9 | [363] |
| Ethyl acetate | 298.15 | - | 117.5 | [363] |
| Ethyl acetate | 303.12 | - | 142.6 | [363] |
| Ethyl acetate | 308.15 | - | 172.3 | [363] |
| Ethyl acetate | 313.15 | - | 210.2 | [363] |
| Ethyl acetate | 318.15 | - | 255.8 | [363] |
| Ethyl acetate | 323.2 | - | 313.3 | [363] |
| Isopropanol | 283.17 | - | 35.05 | [363] |
| Isopropanol | 288.15 | - | 44.62 | [363] |
| Isopropanol | 293.16 | - | 57.26 | [363] |
| Isopropanol | 298.15 | - | 76.71 | [363] |
| Isopropanol | 303.15 | - | 103.7 | [363] |
| Isopropanol | 308.15 | - | 138.6 | [363] |
| Isopropanol | 313.14 | - | 182.7 | [363] |
| Isopropanol | 318.2 | - | 247.0 | [363] |
| Isopropanol | 323.15 | - | 346.7 | [363] |
| Methanol | 283.14 | - | 149.1 | [363] |
| Methanol | 288.15 | - | 190.1 | [363] |
| Methanol | 293.15 | - | 246.8 | [363] |
| Methanol | 298.14 | - | 329.6 | [363] |
| Methanol | 303.15 | - | 445.0 | [363] |
| Methanol | 308.15 | - | 590.8 | [363] |
| Methanol | 313.15 | - | 772.6 | [363] |
| Methanol | 318.75 | - | 999.8 | [363] |
| Methanol | 323.2 | - | 1216.8 | [363] |
Molecule 3D descriptors
| Descriptor | Value |
|---|---|
| PMI1 | 2158.1758 |
| PMI2 | 5400.2330 |
| PMI3 | 6976.2537 |
| NPR1 | 0.3094 |
| NPR2 | 0.7741 |
| RadiusOfGyration | 4.3566 |
| InertialShapeFactor | 0.0004 |
| Eccentricity | 0.9509 |
| Asphericity | 0.3428 |
| SpherocityIndex | 0.2129 |
| PBF | 0.9777 |