Diosmin

CAS Number: 520-27-4

Molecular Mass: 608.5 g/mol

Formula: C₂₈H₃₂O₁₅

Smiles: COc1ccc(-c2cc(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3o2)cc1O

Synonymes:

Diosmin, diosmin, 520-27-4, Barosmin, Diosmine, Venosmine, Flebosten, Tovene, Ven-Detrex, Diovenor, Buchu Resin, Litosmil, flebosmil, Diosminum, Diosmetin 7-O-rutinoside, Diosven, Flebaven, Flebavena, Hemerven, Insuven, Varinon, Dioven, Diosmina, 7QM776WJ5N, DTXSID4045892, 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one, NSC-758417, 3',5,7-trihydroxy-4'-methoxyflavone-7-rutinoside, CHEBI:4631, DTXCID2025892, 3',5,7-trihydroxy-4'-methoxyflavone 7-rhamnoglucoside, 5-hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-2-yl]oxy-chromen-4-one, 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, diosmiplex, Vasculera, Resin, Buchu, 5-hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-7-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl)oxymethyl)tetrahydropyran-2-yl)oxy-chromen-4-one, 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl)oxan-2-yl)oxychromen-4-one, RefChem:35045, C05CA03, 208-289-7, Diosimin, Diosmil, Veno-V, Diosmetin-7-O-rutinoside, MFCD00009772, Rioven, Diosmin [INN], 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one, Diosmin (INN), 4H-1-Benzopyran-4-one,7-[[6-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, Diosmin, analytical standard, 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-4H-1-benzopyran-7-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside, CAS-520-27-4, Diosmin [INN:BAN], Diosmin [INN-Spanish], Diosmine [INN-French], Diosminum [INN-Latin], SR-01000799147, 3',5,7-Trihydroxy-4'-methoxyflavone 7-rutinoside, UNII-7QM776WJ5N, CCRIS 7915, Barosmin, , Daflon, , Diosmin CRS, Ven-Detrex, , NCGC00095022-01, 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, 4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, Diosmin (Standard), EINECS 208-289-7, Daflon (TN), diosmetin-7-rutinose, Diosmin (8), SE 4601, Diosmin - 90%, Salinigricoflavonoloside, , Diosmetin 7-rutinoside, , DIOSMIN [DSC], DIOSMIN [MI], Diosmetin 7-b-rutinoside, DIOSMIN [MART.], DIOSMIN [USP-RS], DIOSMIN [WHO-DD], 3',5,7-Trihydroxy-4'-methoxyflavone-7-(6-O-(-deoxy-alpha-L-mannopyraonsyl)-beta-D-glucopyranoside, MLS001304032, SCHEMBL120870, diosmetin-7-O-beta-D-rutinose, DIOSMIN [EP MONOGRAPH], CHEMBL231884, orb1310207, orb3139707, SCHEMBL29368789, SCHEMBL29449210, SCHEMBL29558633, Diosmin for Sheperd's purse CRS, HY-N0178R, 3',5-Dihydroxy-4'-methoxy-4-oxo-4H-chromen-7-ylrutosid, BDBM153267, GLXC-13353, HMS2233P16, HMS3713L08, Diosmin for system suitability CRS, Tox21_111392, trihydroxymethoxyflavone-O-rutinoside, 3',5-Dihydroxy-4'-methoxy-4-oxo-4H-chromen-7-ylrutosid [IUPAC], EBC-27379, s2292, AKOS015969767, Tox21_111392_1, CCG-208570, DB08995, NSC 758417, OD11673, SMP1_000183, NCGC00344564-01, 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((6-O-alpha-L-rhamnopyranosyl-beta-D-glycopyranosyl)oxy)-4-chromenon, 5-HYDROXY-2-(3-HYDROXY-4-METHOXYPHENYL)-7-{[(2S,3R,4S,5S,6R)-3,4,5-TRIHYDROXY-6-({[(2R,3R,4R,5R,6S)-3,4,5-TRIHYDROXY-6-METHYLOXAN-2-YL]OXY}METHYL)OXAN-2-YL]OXY}-4H-CHROMEN-4-ONE, 7-[6-O-Deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl)oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one, AS-13224, BP-12422, SMR000718616, SY076010, NS00005135, C10039, D07858, EN300-18388399, F795402, 3',5,7-trihydroxy-4'-methoxy flavone-7-rutinoside, Q2607865, SR-01000799147-4, SR-01000799147-5, SR-01000799147-6, 3?,5,7-Trihyd roxy-4?-methoxyflavone 7-rutinoside, BRD-K94436377-001-10-2, BRD-K94436377-001-11-0, Diosmin, European Pharmacopoeia (EP) Reference Standard, Diosmin, United States Pharmacopeia (USP) Reference Standard, Diosmin for system suitability, European Pharmacopoeia (EP) Reference Standard, 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-4H-chromen-7-yl 6-O-(6-deoxy-?-L-mannopyranosyl)-?-D-glucopyranoside, 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chrome, 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(O6-alpha-L-rhamnopyranosyl-beta-D-glucopyranosyloxy)chromen-4-one, 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one, 7-((6-O-(6-DEOXY-GA-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-5-HYDROXY-2-(3-HYDROXY-4-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE, 7-((6-O-(6-Deoxy-ga-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one

Bioactivity: -

Solubility in Different Solvents

Solvent	Temperature [K]	Crystal form	Solubility [mg/mL]	Reference
Ethanol	298.15	-	0.02666	[33]
Ethanol	303.15	-	0.03899	[33]
Ethanol	313.15	-	0.06946	[33]
Ethanol	323.15	-	0.122	[33]
Ethanol	333.15	-	0.1953	[33]
Isopropanol	298.15	-	0.03124	[33]
Isopropanol	303.15	-	0.04421	[33]
Isopropanol	313.15	-	0.0691	[33]
Isopropanol	323.15	-	0.1215	[33]
Isopropanol	333.15	-	0.2098	[33]
Water	298.15	-	0.0421	[33]
Water	303.15	-	0.06289	[33]
Water	313.15	-	0.115	[33]
Water	323.15	-	0.2189	[33]
Water	333.15	-	0.3421	[33]

Molecule 3D descriptors

Descriptor	Value
PMI1	3500.3408
PMI2	23283.0528
PMI3	25553.1264
NPR1	0.1370
NPR2	0.9112
RadiusOfGyration	6.5575
InertialShapeFactor	0.0003
Eccentricity	0.9906
Asphericity	0.6446
SpherocityIndex	0.0889
PBF	0.9875