Tobramycin

CAS Number: 32986-56-4

Molecular Mass: 467.5 g/mol

Formula: C₁₈H₃₇N₅O₉

Smiles: NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)C[C@@H]1O

Synonymes:

Tobramycin, tobramycin, 32986-56-4, Nebramycin VI, Nebramycin 6, Nebramycin factor 6, Tobrex, Tobi, Deoxykanamycin B, 3'-Deoxykanamycin B, Aktob, Tobralex, Tobi Podhaler, vantobra, Tobramicina, Tobramycine, Obramycin, 1-Epitobramycin, Tobramycetin, Tobramycinum, Bethkis, Kitabis Pak, Tobramitsetin, Tenebrimycin, Tenemycin, Nebicin, VZ8RRZ51VK, NSC-180514, DTXSID8023680, (2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol, DTXCID903680, CHEBI:28864, 4-(2,6-Diamino-2,3,6-trideoxy-alpha-D-glycopyranosyl)-6-(3-amino-3-deoxy-alpha-D-glycopyranosyl)-2-deoxystreptamine, D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl-(1-4))-2-deoxy-, O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine, Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-tyrideoxy-alpha-D-ribohexopyranosyl-(1-6))-2-deoxy-, D-, O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine, Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-6))-2-deoxy-, D-, Bramitob, Tobravisc, Tymbrineb, Nebris, Tobramycin solution, (2S,3R,4S,5S,6R)-4-amino-2-((1S,2S,3R,4S,6R)-4,6-diamino-3-((2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl)oxy-2-hydroxycyclohexyl)oxy-6-(hydroxymethyl)oxane-3,5-diol, Tobramycin Inhalation, RefChem:6312, Tobramycin Inhalation Solution, Tobramycin Ophthalmic Solution, J01GB01, S01AA12, Tobramycin Inhalation Solution Pak, 251-322-5, 3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1->6)-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl-(1->4))-2-deoxy-D-streptamine, Tobramicin, Tobramycin Base, Distobram, Tobracin (TN), Tobrex (TN), Tobramycin Deuterated, C18H37N5O9, NSC 180514, Gotabiotic, Tobacin, Tobrased, (2S,3R,4S,5S,6R)-4-amino-2-(((1S,2S,3R,4S,6R)-4,6-diamino-3-(((2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxytetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,5-diol, (2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxy-tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]-6-(hydroxymethyl)tetrahydropyran-3,5-diol, (2S,3R,4S,5S,6R)-4-amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,5-diol, Tobramycine [INN-French], Tobramycinum [INN-Latin], Tobramicina [INN-Spanish], (1S,2S,3R,4S,6R)-4,6-diamino-3-[(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside, O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-->6)-O-[2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl-(1-->4)]-2-deoxy-D-streptamine, TOY, Nebramycin factir 6, HSDB 3259, SR-05000001726, EINECS 251-322-5, UNII-VZ8RRZ51VK, MFCD00077885, SPRC-AB01, BRN 1357507, torbamycin, Kitabis, Nebramycin Factor 6, Deoxykanamycin B, Tobramycin CRS, Nebcin (Sulfate), NCGC00016814-01, D-STREPTAMINE, O-3-AMINO-3-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL-(1->6)-O-(2,6-DIAMINO-2,3,6-TRIDEOXY-.ALPHA.-D-RIBO-HEXOPYRANOSYL-(1->4))-2-DEOXY-, D-Streptamine, O-3-amino-3-deoxy-.alpha.-D-glucopyranosyl-(1->6)-O-[2,6-diamino-2,3,6-trideoxy-.alpha.-D-ribo-hexopyranosyl-(1->4)]-2-deoxy-, Bethkis (TN), CAS-32986-56-4, AT02 - Tobramycin, Tobramycin [USAN:USP:INN:BAN:JAN], Tobi (TN), Spectrum_001072, TOBRAMYCIN [MI], TOBRAMYCIN [INN], TOBRAMYCIN [JAN], Prestwick3_000544, Spectrum2_000078, Spectrum3_000588, Spectrum4_000752, Spectrum5_001038, Tobramycin - high purity, TOBRAMYCIN [HSDB], TOBRAMYCIN [USAN], TOBRAMYCIN [VANDF], Tobramycin (JP18/USP), SCHEMBL2838, TOBRAMYCIN [MART.], CHEMBL1747, TOBRAMYCIN [USP-RS], TOBRAMYCIN [WHO-DD], BSPBio_000587, BSPBio_002036, KBioGR_001104, KBioSS_001552, MLS000069544, BIDD:GT0503, SPECTRUM1500579, SPBio_000295, BPBio1_000647, orb1309215, orb3140193, Tobramycin Deuterated (>90%), TOBRAMYCIN [ORANGE BOOK], GTPL10930, KBio2_001552, KBio2_004120, KBio2_006688, KBio3_001536, ZYLET COMPONENT TOBRAMYCIN, MSK7708, TOBRAMYCIN [EP MONOGRAPH], Tobramycin for identification CRS, GLXC-06548, HMS2090B16, HMS2092M17, HMS2096N09, HMS3713N09, Pharmakon1600-01500579, TOBRAMYCIN [USP MONOGRAPH], HY-B0441, TOBRADEX COMPONENT TOBRAMYCIN, Tox21_110626, BDBM50366778, CCG-39936, EBC-27168, HB4564, MSK7708-100W, NSC757352, s2514, TOBRASONE COMPONENT TOBRAMYCIN, Tobradex (tobramycin + dexamethasone), AKOS016339662, MSK7708-1000W, DB00684, KS-1405, NSC-757352, TOBRADEX ST COMPONENT TOBRAMYCIN, NCGC00178852-01, NCGC00178852-02, Tobramycin Solution in Water, 100ug/mL, AT161114, O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl-(1-6))-2-deoxy-L-streptamine, SMR000058793, SBI-0051915.P003, Tobramycin Solution in Water, 1000ug/mL, Second International Standard for Tobramycin, AB00513858, NS00003131, C00397, D00063, AB00052438-12, AB00052438_13, AB00052438_14, EN300-7480857, F863874, SR-01000721898, Tobramycin, Antibiotic for Culture Media Use Only, Q-201837, Q1758380, SR-01000721898-2, SR-05000001726-1, SR-05000001726-2, BRD-K05619559-001-10-1, BRD-K05619559-001-12-7, (1S,2S,3R,4S,6R)-4,6-diamino-3-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyloxy)-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside, D-Streptamine, O-3-amino-3-deoxy-.alpha.-D-glucopyranosyl-(1->6)-O-[2,6-diamino-2,3,6-trideoxy-.alpha.-D-ribohexopyranosyl-(1->4)]-2-deoxy-, D-Streptamine, O-3-amino-3-deoxy-.alpha.-D-glucopyranosyl-(1?6)-O-[2,6-diamino-2,3,6-trideoxy-.alpha.-D-ribo-hexopyranosyl-(1?4)]-2-deoxy-, O-[3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1->6)]-O-[2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl-(1->4)]-2-deoxy-D-streptamine, O-[3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1?6)]-O-[2,6-diamino-2,3 ,6-trideoxy-alpha-D-ribohexopyranosyl-(1?4)]-2-deoxy-D-streptamine, O-3-AMINO-3-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL-(1->4)-O-(2,6-DIAMINO-2,3,6-TRIDEOXY-.ALPHA.-D-RIBO-HEXOPYRANOSYL-(1.ALPHA.6))-2-DEOXY-L-STREPTAMINE, O-3-Amino-3-deoxy-|A-D-glucopyranosyl-(1 inverted exclamation marku6)-O-[2,6-diamino-2,3,6-trideoxy-|A-D-ribo-hexopyranosyl-(1 inverted exclamation marku4)]-2-deoxy-D-streptamine

Bioactivity: -

Solubility in Different Solvents

Solvent	Temperature [K]	Crystal form	Solubility [mg/mL]	Reference
Dimethyl sulfoxide	294.15	-	82.94	[425]
Dimethyl sulfoxide	298.15	-	93.27	[425]
Dimethyl sulfoxide	303.15	-	119.9	[425]
Dimethyl sulfoxide	308.15	-	157.1	[425]
Dimethyl sulfoxide	313.15	-	187.6	[425]
Dimethyl sulfoxide	318.15	-	234.3	[425]
Dimethylformamide	293.15	-	0.8758	[425]
Dimethylformamide	298.15	-	1.094	[425]
Dimethylformamide	303.15	-	1.499	[425]
Dimethylformamide	308.15	-	2.352	[425]
Dimethylformamide	313.15	-	3.941	[425]
Dimethylformamide	318.15	-	5.575	[425]
Ethanol	283.15	-	3.529	[425]
Ethanol	288.15	-	4.482	[425]
Ethanol	293.15	-	5.679	[425]
Ethanol	298.15	-	9.132	[425]
Ethanol	303.15	-	15.18	[425]
Ethanol	308.15	-	19.19	[425]
Methanol	288.15	-	1.496	[425]
Methanol	293.15	-	1.534	[425]
Methanol	298.15	-	2.167	[425]
Methanol	303.15	-	3.245	[425]
Methanol	308.15	-	4.908	[425]
Methanol	313.15	-	7.157	[425]

Molecule 3D descriptors

Descriptor	Value
PMI1	2239.6220
PMI2	8239.6046
PMI3	8858.2224
NPR1	0.2528
NPR2	0.9302
RadiusOfGyration	4.5476
InertialShapeFactor	0.0004
Eccentricity	0.9675
Asphericity	0.4289
SpherocityIndex	0.2939
PBF	1.2073