Levofloxacin

A synthetic broad-spectrum fluoroquinolone antibiotic used to treat susceptible bacterial infections, including respiratory tract, urinary tract, skin and soft tissue infections. It exhibits bactericidal activity by inhibiting bacterial DNA gyrase and topoisomerase IV, thereby disrupting DNA replication and transcription. Levofloxacin is the pharmacologically active S-(-)-enantiomer of ofloxacin

Compound Structure

CAS Number: 100986-85-4

Molecular Mass: 361.4 g/mol

Formula: C18H20FN3O4

Smiles: C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23

Synonymes:

Bioactivity: Fluoroquinolone antibiotic; bacterial DNA gyrase and topoisomerase IV inhibitor

Solubility in Different Solvents

Solvent Temperature [K] Crystal form Solubility [mg/mL] Reference
1-Butanol 288.15 - 5.771 [42]
1-Butanol 293.15 - 6.928 [42]
1-Butanol 298.15 - 8.635 [42]
1-Butanol 303.15 - 10.51 [42]
1-Butanol 308.15 - 13.7 [42]
1-Butanol 313.15 - 17.52 [42]
1-Butanol 318.15 - 23.37 [42]
1-Butanol 323.15 - 30.67 [42]
1-Butanol 328.15 - 35.19 [42]
1-Propanol 288.15 - 5.304 [42]
1-Propanol 293.15 - 5.83 [42]
1-Propanol 298.15 - 6.843 [42]
1-Propanol 303.15 - 8.657 [42]
1-Propanol 308.15 - 11.15 [42]
1-Propanol 313.15 - 13.49 [42]
1-Propanol 318.15 - 17.7 [42]
1-Propanol 323.15 - 21.15 [42]
1-Propanol 328.15 - 26.82 [42]
Acetic acid 298.15 - 372.0 [42]
Acetic acid 303.15 - 383.8 [42]
Acetic acid 308.15 - 399.1 [42]
Acetic acid 313.15 - 412.8 [42]
Acetic acid 318.15 - 427.7 [42]
Acetic acid 323.15 - 440.6 [42]
Acetic acid 328.15 - 449.7 [42]
Ethanol 288.15 - 3.55 [42]
Ethanol 293.15 - 4.909 [42]
Ethanol 298.15 - 6.594 [42]
Ethanol 303.15 - 8.22 [42]
Ethanol 308.15 - 10.88 [42]
Ethanol 313.15 - 15.43 [42]
Ethanol 318.15 - 19.4 [42]
Ethanol 323.15 - 24.77 [42]
Ethanol 328.15 - 31.49 [42]
Ethyl acetate 288.15 - 7.186 [42]
Ethyl acetate 293.15 - 7.799 [42]
Ethyl acetate 298.15 - 8.13 [42]
Ethyl acetate 303.15 - 9.001 [42]
Ethyl acetate 308.15 - 10.24 [42]
Ethyl acetate 313.15 - 11.64 [42]
Ethyl acetate 318.15 - 13.6 [42]
Ethyl acetate 323.15 - 17.25 [42]
Ethyl acetate 328.15 - 19.59 [42]
Isopropanol 288.15 - 2.09 [42]
Isopropanol 293.15 - 2.576 [42]
Isopropanol 298.15 - 3.01 [42]
Isopropanol 303.15 - 3.839 [42]
Isopropanol 308.15 - 4.796 [42]
Isopropanol 313.15 - 6.263 [42]
Isopropanol 318.15 - 7.531 [42]
Isopropanol 323.15 - 9.93 [42]
Isopropanol 328.15 - 12.26 [42]

Molecule 3D descriptors

Descriptor Value
PMI1 1094.6828
PMI2 4613.4328
PMI3 5431.6704
NPR1 0.2015
NPR2 0.8494
RadiusOfGyration 3.9260
InertialShapeFactor 0.0008
Eccentricity 0.9795
Asphericity 0.5135
SpherocityIndex 0.1610
PBF 0.7365