Candesartan cilexetil

Molecular Mass: 610.7 g/mol

Formula: C₃₃H₃₄N₆O₆

Smiles: CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1

Synonymes:

Candesartan cilexetil, 145040-37-5, Atacand, TCV-116, Amias, Ratacand, DTXSID5020239, NSC-758697, R85M2X0D68, DTXCID50239, 1H-Benzimidazolium, 7-carboxy-1-(2-((cyclohexylcarbonyl)oxy)ethyl)-2-ethoxy-1-(2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)-, hydroxide, inner salt, (+-)-, Candesartan 1-(((cyclohexyloxy)carbonyl)oxy)ethyl ester, Candesartan 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester, RefChem:56666, 1-(cyclohexylocarbonyloxy)ethyl-2-ethoxy-1-(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)-1H-benzimidazole-7-carboxylate, (1RS)-1-(Cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1H-benzimidazole-7-carboxylate, candesartancilexetil, Parapres, Kenzen, CANDESARTAN CILEXTIL, Candesartan cilexetil [USAN], MFCD00871371, CHEMBL1014, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate, 1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate, 1-(cyclohexyloxycarbonyloxy)ethyl 1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate, 2-Ethoxy-1-[(2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-7-benzimidazolecarboxylic acid 1-(cyclohexyloxycarbonyloxy)ethyl ester, TCV 116, candesartan cilexitil, Racanda, UNII-R85M2X0D68, Candesartan hexetil, Atacand (TN), Candesartan cilexetil?, Spectrum_001707, Spectrum2_000485, Spectrum3_000996, Spectrum4_001124, Spectrum5_001462, Candesartan cilexetil CRS, Candesartan Celexetil Ester, SCHEMBL40831, BSPBio_002691, KBioGR_001607, KBioSS_002187, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(1h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-benzimidazole-7-carboxylate, MLS004774127, Candesartan cilexetil , 97%, SCHEMBL612936, SPECTRUM1504261, SPBio_000349, CHEBI:3348, GTPL8352, orb1305541, Candesartan cilexetil (Atacand), Candesartan Cilexetil (Standard), KBio2_002187, KBio2_004755, KBio2_007323, KBio3_001911, TCY 116, GLXC-07961, HMS1922J09, HMS2093E20, HMS3651I08, HMS5080P17, Pharmakon1600-01504261, Candesartan cilexetil (JP18/USP), CANDESARTAN CILEXETIL [JAN], ALBB-038627, MSK10658, Tox21_302202, AC-204, BDBM50318907, CANDESARTAN CILEXETIL [VANDF], CCG-39530, EBC-11266, HY-17505R, NSC758697, s2037, STL451065, CANDESARTAN CILEXETIL [MART.], AKOS015894954, AKOS015920180, CANDESARTAN CILEXETIL [USP-RS], CANDESARTAN CILEXETIL [WHO-DD], AB07617, CCG-222334, DB00796, DS-1302, EBC-656142, FC19661, KS-1147, NSC 758697, Candesartan cilexetil, >=98% (HPLC), NCGC00095123-01, NCGC00095123-02, NCGC00095123-03, NCGC00095123-05, NCGC00095123-10, NCGC00095123-16, NCGC00255218-01, (+-)-1-Hydroxyethyl 2-ethoxy-1-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-7-benzimidazolecarboxylate, cyclohexyl carbonate (ester), 1-(((cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate, 1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 2-(ethyloxy)-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate, 1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-1,3-benzodiazole-7-carboxylate, 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, 1-(((cyclohexyloxy)carbonyl)oxy)ethyl ester, (+-)-, 2-ETHOXY-1-[[2'-(2H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-BENZIMIDAZOLE-7-CARBOXYLIC ACID 1-[[(CYCLOHEXYLOXY)CARBONYL]OXY]ETHYL ESTER, 2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid 1-cyclohexyloxycarbonyloxy-ethyl ester, BC164274, Candesartan cilexetil - Bio-X trade mark, HY-17505, SMR003500784, SY051248, CANDESARTAN CILEXETIL [ORANGE BOOK], SBI-0206767.P001, CANDESARTAN CILEXETIL [EP MONOGRAPH], C2635, CANDESARTAN CILEXETIL [USP MONOGRAPH], CAS-145040-37-5, NS00006138, SW220041-1, C07709, D00626, EN300-118698, AB01274805-01, AB01274805_02, AB01274805_03, Candesartan cilexetil for peak identification CRS, Candesartan cilexetil for system suitability CRS, H212/91, L006257, SR-05000001976, SR-05000001976-1, BRD-A65671304-001-02-6, BRD-A65671304-001-03-4, BRD-A65671304-001-07-5, BRD-A65671304-001-08-3, Q27075664, Z1515383338, CANDESARTAN 1-(((CYCLOHEXYLOXY)CARBONYL)OXY)ETHYL ESTER [MI], Candesartan cilexetil, European Pharmacopoeia (EP) Reference Standard, Candesartan cilexetil, United States Pharmacopeia (USP) Reference Standard, Candesartan cilexetil for peak identification, European Pharmacopoeia (EP) Reference Standard, Candesartan cilexetil for system suitability, European Pharmacopoeia (EP) Reference Standard, Candesartan Cilexetil, Pharmaceutical Secondary Standard, Certified Reference Material, (+/-)-1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[2'-(1H-tetrazol-5-yl) biphenyl-4-yl]methylbenzimidazole-7-carboxylate, (+/-)-1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methylbenzimidazole-7-carboxylate, (+/-)-1-HYDROXYETHYL 2-ETHOXY-1-(P-(O-1H-TETRAZOL-5-YLPHENYL)BENZYL)-7-BENZIMIDAZOLECARBOXYLATE, CYCLOHEXYL CARBONATE (ESTER), 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate, 1-(Cyclohexyloxycarbonyloxy)ethyl-2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazol-7-carboxylate, 1-{[(Cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-1,3-benzimidazole-7-carboxylate, 1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate, 1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2'-(2H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-1,3-benzodiazole-7-carboxylate, 1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl] methyl]benzimidazole-4-carboxylate, 1H-BENZIMIDAZOLE-7-CARBOXYLIC ACID, 2-ETHOXY-1-((2'-(1H-TETRAZOL-5-YL)(1,1'-BIPHENYL)-4-YL)METHYL)-, 1-(((CYCLOHEXYLOXY)CARBONYL)OXY)ETHYL ESTER, (+/-)-, 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]et hyl ester, 2-Ethoxy-3-[2''-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid 1-cyclohexyloxycarbonyloxy-ethyl ester, 2-Ethoxy-3-[2''-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid 1-cyclohexyloxycarbonyloxy-ethyl ester, 2-ethoxy-3-[2'-(1h-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3h-benzoimidazole-4-carboxylic acid 1-cyclohe

Bioactivity: -

Solubility in Different Solvents

Solvent	Temperature [K]	Crystal form	Solubility [mg/mL]	Reference
1-Propanol	278.15	-	5.14	[44]
1-Propanol	283.15	-	6.52	[44]
1-Propanol	288.15	-	8.05	[44]
1-Propanol	293.15	-	10.79	[44]
1-Propanol	298.15	-	14.0	[44]
1-Propanol	303.15	-	16.85	[44]
1-Propanol	308.15	-	22.83	[44]
1-Propanol	313.15	-	29.96	[44]
1-Propanol	318.15	-	36.14	[44]
1-Propanol	323.15	-	47.0	[44]
1-Propanol	328.15	-	60.24	[44]
1-Propanol	333.15	-	77.26	[44]
Acetone	278.15	-	32.64	[44]
Acetone	283.15	-	39.57	[44]
Acetone	288.15	-	47.66	[44]
Acetone	293.15	-	56.27	[43]
Acetone	293.15	-	56.29	[44]
Acetone	298.15	-	65.15	[43]
Acetone	298.15	-	65.13	[44]
Acetone	303.15	-	78.23	[43]
Acetone	303.15	-	78.23	[44]
Acetone	308.15	-	91.28	[43]
Acetone	308.15	-	91.28	[44]
Acetone	313.15	-	108.7	[43]
Acetone	313.15	-	108.8	[44]
Acetone	318.15	-	126.0	[44]
Acetone	323.15	-	147.4	[44]
Acetonitrile	278.15	-	3.09	[44]
Acetonitrile	283.15	-	3.9	[44]
Acetonitrile	288.15	-	5.16	[44]
Acetonitrile	293.15	-	6.772	[43]
Acetonitrile	293.15	-	6.75	[44]
Acetonitrile	298.15	-	8.21	[44]
Acetonitrile	303.15	-	10.48	[43]
Acetonitrile	303.15	-	10.5	[44]
Acetonitrile	308.15	-	14.49	[44]
Acetonitrile	313.15	-	18.11	[43]
Acetonitrile	313.15	-	18.02	[44]
Acetonitrile	318.15	-	21.94	[44]
Acetonitrile	323.15	-	29.36	[43]
Acetonitrile	323.15	-	29.4	[44]
Acetonitrile	328.15	-	38.08	[44]
Acetonitrile	333.15	-	48.69	[43]
Acetonitrile	333.15	-	48.75	[44]
Ethanol	278.15	-	5.86	[44]
Ethanol	283.15	-	6.98	[44]
Ethanol	288.15	-	9.05	[44]
Ethanol	293.15	-	10.79	[44]
Ethanol	298.15	-	13.6	[44]
Ethanol	303.15	-	14.92	[43]
Ethanol	303.15	-	16.9	[44]
Ethanol	308.15	-	20.94	[44]
Ethanol	313.15	-	24.11	[43]
Ethanol	313.15	-	27.81	[44]
Ethanol	318.15	-	36.25	[44]
Ethanol	323.15	-	47.3	[43]
Ethanol	323.15	-	46.55	[44]
Ethanol	328.15	-	57.95	[44]
Ethanol	333.15	-	83.05	[43]
Ethanol	333.15	-	77.8	[44]
Ethanol	343.15	-	117.9	[43]
Isopropanol	278.15	-	2.11	[44]
Isopropanol	283.15	-	2.99	[44]
Isopropanol	288.15	-	4.18	[44]
Isopropanol	293.15	-	5.6	[44]
Isopropanol	298.15	-	7.39	[44]
Isopropanol	303.15	-	10.12	[44]
Isopropanol	308.15	-	13.4	[44]
Isopropanol	313.15	-	17.29	[44]
Isopropanol	318.15	-	23.2	[44]
Isopropanol	323.15	-	30.29	[44]
Isopropanol	328.15	-	40.57	[44]
Isopropanol	333.15	-	51.22	[44]
Methyl ethyl ketone	278.15	-	40.19	[44]
Methyl ethyl ketone	283.15	-	45.4	[44]
Methyl ethyl ketone	288.15	-	51.78	[44]
Methyl ethyl ketone	293.15	-	59.2	[44]
Methyl ethyl ketone	298.15	-	68.49	[44]
Methyl ethyl ketone	303.15	-	80.35	[44]
Methyl ethyl ketone	308.15	-	93.54	[44]
Methyl ethyl ketone	313.15	-	108.0	[44]
Methyl ethyl ketone	318.15	-	128.0	[44]
Methyl ethyl ketone	323.15	-	150.1	[44]
Methyl ethyl ketone	328.15	-	176.4	[44]
Methyl ethyl ketone	333.15	-	207.0	[44]

Molecule 3D descriptors

Descriptor	Value
PMI1	8261.0333
PMI2	8462.1310
PMI3	13629.3614
NPR1	0.6061
NPR2	0.6209
RadiusOfGyration	4.9852
InertialShapeFactor	0.0001
Eccentricity	0.7954
Asphericity	0.1206
SpherocityIndex	0.3400
PBF	1.4965