Ofloxacin

CAS Number: 82419-36-1

Molecular Mass: 361.4 g/mol

Formula: C₁₈H₂₀FN₃O₄

Smiles: CC1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23

Synonymes:

Ofloxacin, ofloxacin, 82419-36-1, Floxin, Ofloxacine, Tarivid, Ocuflox, Ofloxacino, Visiren, Ofloxacinum, Exocin, DL-8280, Hoe-280, Ofloxacina, Floxin otic, Ofloxacin Otic, OFLX, HOE 280, FLOXIN IN DEXTROSE 5%, DL 8280, A4P49JAZ9H, NSC-727071, NSC-758178, CHEBI:7731, 7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid, DTXSID3041085, FLOXIN IN DEXTROSE 5% IN PLASTIC CONTAINER, J01MA01, DTXCID1021085, NSC727071, 8-Fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid, 9-FLUORO-2,3-DIHYDRO-3-METHYL-10-(4-METHYL-1-PIPERAZINYL)-7-OXO-7H-PYRIDO(1,2,3-DE)(1,4)BENZOXAZINE-6-CARBOXYLIC ACID, DL-, Ofloxaxin, Tarivid i.v., 7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo(7.3.1.05,13)trideca-5(13),6,8,11-tetraene-11-carboxylic acid, Ofloxacin Ophthalmic, Olfoxacin Otic Soln, Ofloxacin Ophth Soln, Tarivid 400, Ofloxacin Otic solution, RefChem:6082, 7-fluoro-2-methyl-6-(4-methylpiperazin-4-ium-1-yl)-10-oxo-4-oxa-1-azatricyclo(7.3.1.05,13)trideca-5(13),6,8,11-tetraene-11-carboxylate, S01AE01, S02AA16, Ru43280, ORF28489, ORF 28489, Ru 43280, DR 3355, Ofloxacin Ophthalmic Solution USP, 0.3%, (+-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7--oxo-7H-pyrido(1,2,3-de)--1,4-benzoxazine-6-carboxylic acid, (3RS)-9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-pyrido(1,2,3-de)(1,4)benzoxazine-6-carboxylic acid, DL8280, Hoe280, 83380-47-6, 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid, MFCD00226105, Oxaldin, Oflocet, 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid, CHEMBL4, MLS000028749, 9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, Ofloxacina [DCIT], Ofloxacine [French], Ofloxacinum [Latin], Exocine, Flobacin, SMR000058192, Zanocin, Floxil, Ofloxacino [Spanish], 9-Fluoro-3,7-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic Acid, OFX, F0472-0226, PT 01, Levofloxacin-13C-D3, ORF 18489, 7-Fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5,7,9(13),11-tetraene-11-carboxylic acid, Floxin (TN), CCRIS 5233, (+/-)-Floxin, SR-01000076050, UNII-A4P49JAZ9H, BRN 3657947, Monoflocet, DL-ofloxacin, Mefoxacin, , Flobacin, , Ocuflox, , Oflocet, , Oflocin, , Oxaldin, , s1940, Exocin, , Ofloxacin CRS, HSDB 8030, NCGC00016948-01, (-)-(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1, (-)-(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1, Ofloxacin (Floxin), CAS-82419-36-1, Exocin (eye drops), Ofloxacin (Standard), Ofloxacin [USAN:USP:INN:BAN:JAN], (+-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, WP-0405, Spectrum_001186, OFLOXACIN [INN], OFLOXACIN [JAN], OFLOXACIN [MI], OFLOXACIN [USAN], Opera_ID_1114, Prestwick0_000237, Prestwick1_000237, Prestwick2_000237, Prestwick3_000237, Spectrum2_001464, Spectrum3_001499, Spectrum4_000324, Spectrum5_001063, OFLOXACIN [VANDF], Epitope ID:116889, OFLOXACIN [MART.], O 8757, OFLOXACIN [USP-RS], OFLOXACIN [WHO-DD], Lopac0_000904, Oprea1_242882, SCHEMBL24373, BSPBio_000313, BSPBio_003117, KBioGR_000667, KBioSS_001666, fluoro-methyl-(4-methylpiperazin-1-yl)-oxo-[?]carboxylic acid, MLS001074203, MLS006011774, orb320681, DivK1c_000721, SPECTRUM1502044, SPBio_001387, SPBio_002234, Ofloxacin (JP18/USP/INN), BPBio1_000345, orb1310184, orb3139966, OFLOXACIN [ORANGE BOOK], OFLOXACIN [EP MONOGRAPH], SCHEMBL14163982, GTPL10918, HMS502E03, HY-B0125R, KBio1_000721, KBio2_001666, KBio2_004234, KBio2_006802, KBio3_002617, MSK5740, OFLOXACIN [USP MONOGRAPH], CHEBI:194135, NINDS_000721, AO128, HMS1568P15, HMS1921H12, HMS2090F07, HMS2092B10, HMS2095P15, HMS2235C05, HMS3259G07, HMS3262F10, HMS3369B01, HMS3393K06, HMS3604B17, HMS3712P15, HMS5080D07, HMS5083P19, HMS5087O15, Pharmakon1600-01502044, SMSSF-0055683, (S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, HY-B0125, RKL10083, UYB17021, Ofloxacin, fluoroquinolone antibiotic, Tox21_110703, Tox21_500904, BBL005605, BDBM50045004, CCG-39210, EBC-08557, MSK5740-100M, NSC758178, s1463, STK256723, AKOS001033517, AKOS016042783, Ofloxacine, DL-8280, HOE-280, Tox21_110703_1, AC-7616, AO26535, CS-1891, DB01165, KS-5011, LP00904, NC00466, NSC 727071, NSC 758178, SDCCGSBI-0050879.P004, IDI1_000721, NCGC00015772-02, NCGC00015772-03, NCGC00015772-04, NCGC00015772-05, NCGC00015772-06, NCGC00015772-07, NCGC00015772-08, NCGC00015772-09, NCGC00015772-10, NCGC00015772-12, NCGC00015772-13, NCGC00015772-22, NCGC00094219-01, NCGC00094219-02, NCGC00094219-03, NCGC00094219-04, NCGC00094219-05, NCGC00094219-06, NCGC00178284-01, NCGC00178284-02, NCGC00261589-01, Ofloxacin 100 microg/mL in Acetonitrile, (+-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)(1,4)benzoxazin-6-carbonsaeure, (+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 2,3-dihydro-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (+-)-, 7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (+-)-, ST073364, SY052697, Ofloxacin Solution in Methanol, 100ug/mL, SBI-0050879.P003, TARIVID, AKOS NCG1-0050, KFLOXACIN, DB-056608, AB00513820, EU-0100904, NS00098749, O0403, EN300-06482, Ofloxacin, VETRANAL(TM), analytical standard, VU0243192-7, C07321, D00453, AB00052263-12, AB00052263-13, AB00052263_14, AB00052263_15, F858780, Q411447, SR-01000076050-1, SR-01000076050-4, SR-01000076050-7, BRD-A24228527-001-05-9, BRD-A24228527-001-19-0, BRD-A24228527-001-31-5, BRD-A24228527-213-01-9, SR-01000076050-16, Z56761309, F0020-0095, Ofloxacin, European Pharmacopoeia (EP) Reference Standard, Ofloxacin, United States Pharmacopeia (USP) Reference Standard, (+/-)-9-Fluoro-2,2,3-de)-1,4-benzoxazine-6-carboxylic acid, Ofloxacin, Pharmaceutical Secondary Standard, Certified Reference Material, (RS)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.0,5,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid, 7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, 7H-PYRIDO(1,2,3-DE)-1,4-BENZOXAZINE-6-CARBOXYLIC ACID, 9-FLUORO-2,3-DIHYDRO-3-METHYL-10-(4-METHYL-1-PIPERAZINYL)-7-OXO-, (+/-)-, 8-fluoro-3-methyl-9-(4-methyl-1-piperazinyl)-6-oxo-1-oxa-3a-aza-2,3-dihydro-6H-phenalene-5-carboxylic acid, 9-Fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido [1,2,3-de]-1,4-Benzoxazin-6-carboxylic Acid, 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid, 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylicacid, 9-fluoro-3-methyl-10-(4-methylpiperazino)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid

Bioactivity: -

Solubility in Different Solvents

Solvent	Temperature [K]	Crystal form	Solubility [mg/mL]	Reference
1-Octanol	293.15	-	0.116	[170]
1-Octanol	298.15	-	0.1437	[170]
1-Octanol	303.15	-	0.1767	[170]
1-Octanol	308.15	-	0.2149	[170]
1-Octanol	313.15	-	0.265	[170]
1-Octanol	318.15	-	0.3188	[170]
1-Octanol	323.15	-	0.3905	[170]
1-Octanol	328.15	-	0.4721	[170]
1-Octanol	333.15	-	0.5632	[170]
Carbon tetrachloride	293.15	-	5.491	[479]
Carbon tetrachloride	295.15	-	6.981	[479]
Carbon tetrachloride	298.15	-	9.199	[479]
Carbon tetrachloride	300.15	-	10.67	[479]
Carbon tetrachloride	303.15	-	12.85	[479]
Carbon tetrachloride	305.15	-	13.67	[479]
Carbon tetrachloride	308.15	-	14.88	[479]
Carbon tetrachloride	310.15	-	15.71	[479]
Carbon tetrachloride	313.15	-	16.87	[479]
Chloroform	293.15	-	15.01	[479]
Chloroform	295.15	-	16.3	[479]
Chloroform	298.15	-	18.21	[479]
Chloroform	300.15	-	19.49	[479]
Chloroform	303.15	-	21.39	[479]
Chloroform	305.15	-	23.23	[479]
Chloroform	308.15	-	25.97	[479]
Chloroform	310.15	-	27.8	[479]
Chloroform	313.15	-	30.51	[479]
Dichloromethane	293.15	-	17.57	[479]
Dichloromethane	295.15	-	19.26	[479]
Dichloromethane	298.15	-	21.78	[479]
Dichloromethane	300.15	-	23.44	[479]
Dichloromethane	303.15	-	25.91	[479]
Dichloromethane	305.15	-	28.16	[479]
Dichloromethane	308.15	-	31.49	[479]
Dichloromethane	310.15	-	33.72	[479]
Dichloromethane	313.15	-	37.04	[479]
Water	293.15	-	2.868	[169]
Water	293.15	-	3.124	[479]
Water	295.15	-	3.624	[479]
Water	298.15	-	3.009	[169]
Water	298.15	-	4.581	[479]
Water	300.15	-	4.879	[479]
Water	303.15	-	3.18	[169]
Water	303.15	-	5.614	[479]
Water	305.15	-	5.93	[479]
Water	308.15	-	3.387	[169]
Water	308.15	-	6.403	[479]
Water	310.15	-	6.937	[479]
Water	313.15	-	3.647	[169]
Water	313.15	-	7.208	[479]
Water	318.15	-	3.894	[169]

Molecule 3D descriptors

Descriptor	Value
PMI1	1091.4117
PMI2	4630.5831
PMI3	5454.5756
NPR1	0.2001
NPR2	0.8489
RadiusOfGyration	3.9324
InertialShapeFactor	0.0008
Eccentricity	0.9798
Asphericity	0.5162
SpherocityIndex	0.1617
PBF	0.7373