Lomefloxacin

A synthetic broad-spectrum fluoroquinolone antibiotic used for the treatment of susceptible bacterial infections, particularly urinary tract and respiratory tract infections. It exhibits bactericidal activity by inhibiting bacterial DNA gyrase and topoisomerase IV, thereby interfering with DNA replication and transcription.

CAS Number: 98079-51-7

Molecular Mass: 351.35 g/mol

Formula: C₁₇H₁₉F₂N₃O₃

Smiles: CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(C)C3)c(F)c21

Synonymes:

Lomefloxacin, lomefloxacin, 98079-51-7, Lomefloxacine, Lomefloxacino, Lomefloxacinum, LFLX, 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, SC-47111A, L6BR2WJD8V, 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid, 1,4-Dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, CHEBI:116278, (+-)-1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, DTXSID4040680, Logiflox, Okacin, 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, SC-4711, lomefloxacina, lomenfloxacin, RefChem:153984, 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, monohydrochloride, DTXCID2020680, J01MA07, S01AE04, Lomefloxacine [French], Lomefloxacino [Spanish], Lomefloxacinum [Latin], DM 10 (bactericide), DM-10, 1-ethyl-6-fluoranyl-8-fluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid, Lomefloxacin (USAN), LOMEFLOXACIN [USAN], 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid, SC 47111A, 1-ethyl-6,8-difluoro-7-(3-methylpiperazinyl)-4-oxohydroquinoline-3-carboxylic acid, 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, CCRIS 6305, Maxaquin (hydrochloride), UNII-L6BR2WJD8V, NY-198 (hydrochloride), BRN 4210041, SC-47111B (mesylate), SC-47111 (hydrochloride), Lomefloxacin [USAN:INN:BAN], C17H19F2N3O3, Spectrum_001431, Prestwick0_000238, Prestwick1_000238, Prestwick2_000238, Prestwick3_000238, Spectrum2_000696, Spectrum3_001494, Spectrum4_000158, Spectrum5_001246, LOMEFLOXACIN [MI], LOMEFLOXACIN [INN], CHEMBL561, Epitope ID:119067, LOMEFLOXACIN [VANDF], Lopac0_000678, SCHEMBL34609, BSPBio_000315, BSPBio_003107, KBioGR_000636, KBioSS_001911, DivK1c_000365, LOMEFLOXACIN [WHO-DD], SPBio_000851, SPBio_002236, BPBio1_000347, orb1308596, SCHEMBL29388501, GTPL12407, HY-B0455A, KBio1_000365, KBio2_001911, KBio2_004479, KBio2_007047, KBio3_002607, NINDS_000365, HMS2090O16, HMS5084D10, RKL10067, BDBM50417952, EBC-26691, s5491, SBB012581, STL483414, AKOS015964770, CCG-204764, DB00978, KS-5014, SDCCGSBI-0050657.P004, 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid, IDI1_000365, SMP1_000287, NCGC00015603-02, NCGC00015603-03, NCGC00015603-04, NCGC00015603-05, NCGC00015603-07, NCGC00015603-16, NCGC00162221-01, NCGC00178293-01, NCGC00178293-02, 3-Quinolinecarboxylic acid, 1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-, 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, (+-)-, FL170160, ST072201, SBI-0050657.P003, Lomefloxacin 1000 microg/mL in Acetonitrile, NS00007577, C07078, D02318, G85922, AB00053622-04, AB00053622-05, AB00053622_06, AB00053622_07, EN300-18553898, F866703, Q203618, BRD-A75850590-003-05-6, BRD-A75850590-003-06-4, BRD-A75850590-003-09-8, BRD-A75850590-213-01-0, (+/-)-1-ETHYL-6,8-DIFLUORO-1,4-DIHYDRO-7-(3-METHYL-1-PIPERAZINYL)-4-, (+/-)-1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo- (+/-), 3-QUINOLINECARBOXYLIC ACID, 1-ETHYL-6,8-DIFLUORO-1,4-DIHYDRO-7-(3-METHYL-1-PIPERAZINYL)-4-OXO-, (+/-)-

Bioactivity: Fluoroquinolone antibiotic; bacterial DNA gyrase (topoisomerase II) and topoisomerase IV inhibitor.

Solubility in Different Solvents

Solvent	Temperature [K]	Crystal form	Solubility [mg/mL]	Reference
1-Octanol	293.15	-	0.0048	[170]
1-Octanol	298.15	-	0.0061	[170]
1-Octanol	303.15	-	0.0078	[170]
1-Octanol	308.15	-	0.0101	[170]
1-Octanol	313.15	-	0.0129	[170]
1-Octanol	318.15	-	0.0166	[170]
1-Octanol	323.15	-	0.0215	[170]
1-Octanol	328.15	-	0.028	[170]
1-Octanol	333.15	-	0.0361	[170]
Water	293.15	-	0.6781	[169]
Water	298.15	-	0.7329	[169]
Water	303.15	-	0.8409	[169]
Water	308.15	-	0.9502	[169]
Water	313.15	-	1.09	[169]
Water	318.15	-	1.263	[169]
Water	323.15	-	1.459	[169]

Molecule 3D descriptors

Descriptor	Value
PMI1	1052.7241
PMI2	4432.6000
PMI3	5199.0657
NPR1	0.2025
NPR2	0.8526
RadiusOfGyration	3.8993
InertialShapeFactor	0.0008
Eccentricity	0.9793
Asphericity	0.5116
SpherocityIndex	0.1630
PBF	0.7351