Norfloxacin

A synthetic broad-spectrum fluoroquinolone antibiotic used primarily for the treatment of susceptible urinary tract and gastrointestinal bacterial infections. It exhibits bactericidal activity by targeting bacterial DNA gyrase and topoisomerase IV, disrupting DNA replication and other essential DNA processes.

Compound Structure

CAS Number: 70458-96-7

Molecular Mass: 319.33 g/mol

Formula: C16H18FN3O3

Smiles: CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)cc21

Synonymes:

Bioactivity: Fluoroquinolone antibiotic; bacterial DNA gyrase and topoisomerase IV inhibitor

Solubility in Different Solvents

Solvent Temperature [K] Crystal form Solubility [mg/mL] Reference
1-Octanol 293.15 - 0.1045 [170]
1-Octanol 298.15 - 0.1335 [170]
1-Octanol 303.15 - 0.1714 [170]
1-Octanol 308.15 - 0.2163 [170]
1-Octanol 313.15 - 0.2795 [170]
1-Octanol 318.15 - 0.351 [170]
1-Octanol 323.15 - 0.4404 [170]
1-Octanol 328.15 - 0.5582 [170]
1-Octanol 333.15 - 0.6872 [170]
Water 293.15 - 0.3578 [169]
Water 298.15 - 0.4012 [169]
Water 303.15 - 0.4485 [169]
Water 308.15 - 0.5136 [169]
Water 313.15 - 0.594 [169]
Water 318.15 - 0.6895 [169]
Water 323.15 - 0.8214 [169]

Molecule 3D descriptors

Descriptor Value
PMI1 892.5001
PMI2 3964.0337
PMI3 4735.2971
NPR1 0.1885
NPR2 0.8371
RadiusOfGyration 3.8754
InertialShapeFactor 0.0009
Eccentricity 0.9821
Asphericity 0.5390
SpherocityIndex 0.0957
PBF 0.5750