Norfloxacin
A synthetic broad-spectrum fluoroquinolone antibiotic used primarily for the treatment of susceptible urinary tract and gastrointestinal bacterial infections. It exhibits bactericidal activity by targeting bacterial DNA gyrase and topoisomerase IV, disrupting DNA replication and other essential DNA processes.
CAS Number: 70458-96-7
Molecular Mass: 319.33 g/mol
Formula: C16H18FN3O3
Smiles: CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)cc21
Synonymes:
Norfloxacin, norfloxacin, 70458-96-7, Noroxin, Norfloxacine, Chibroxin, Baccidal, Sebercim, MK-366, Norfloxacino, Fulgram, Norfloxacinum, 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid, AM-715, NFLX, 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, Utinor, DTXSID7037680, 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid, NSC-757250, N0F8P22L1P, CHEBI:100246, 1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsaeure, DTXCID5017680, 3-Quinolinecarboxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-, MK366, MK0366, AM0715, MK 366, AM 0715, norfloxacina, Quinabic, 1-ethyl-6-fluoro-4-oxo-7-piperazin-4-ium-1-ylquinoline-3-carboxylate, RefChem:57698, J01MA06, S01AE02, 274-614-4, Barazan, MFCD00079532, C16H18FN3O3, Lexinor, Zoroxin, MK-0366, 1-Ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid, CHEMBL9, 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid, MLS000069650, 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-quinoline-3-carboxylic acid, NCGC00016916-01, NCGC00016916-09, SMR000058200, CAS-70458-96-7, Norfloxacine [INN-French], Norfloxacinum [INN-Latin], Norfloxacino [INN-Spanish], AM 715, Noflo, Norflo, MK 0366, 1-ethyl-6-fluoro-4-oxo-7-piperazinylhydroquinoline-3-carboxylic acid, Noroxin (TN), CCRIS 6302, SR-01000000222, EINECS 274-614-4, BRN 0567897, UNII-N0F8P22L1P, Chibroxine, Chibroxol, Gonorcin, Nolicin, Noracin, Noraxin, Norocin, Noroxine, Norxacin, Uroxacin, Amicrobin, , Chibroxin, , Baccidal, , Esclebin, , Fortimax, , Barazan, , Espeden, , Fulgram, , Lexinor, , Norfloxacin CRS, Nalion, , HSDB 8029, Prestwick_633, Norfloxacin protomer I, Norfloxacin [USAN:USP:INN:BAN:JAN], Norfloxacin (Norxacin), Norfloxacin (Standard), Norfloxacin protomer II, Spectrum_001017, NORFLOXACIN [MI], Opera_ID_1423, Prestwick0_000221, Prestwick1_000221, Prestwick2_000221, Prestwick3_000221, Spectrum2_001017, Spectrum3_000524, Spectrum4_000453, Spectrum5_001154, NORFLOXACIN [INN], NORFLOXACIN [JAN], PEFLOXACINE_met009, NORFLOXACIN [USAN], Epitope ID:119068, NORFLOXACIN [VANDF], SCHEMBL3473, NORFLOXACIN [MART.], Oprea1_375152, BSPBio_000261, BSPBio_002107, KBioGR_000866, KBioSS_001497, NORFLOXACIN [USP-RS], NORFLOXACIN [WHO-DD], MLS006011446, BIDD:GT0725, DivK1c_000084, SPECTRUM1500440, SPBio_001173, SPBio_002182, BPBio1_000289, orb1309041, orb3025251, Norfloxacin (JP18/USP/INN), BCBcMAP01_000218, GTPL12408, HMS500E06, HY-B0132R, KBio1_000084, KBio2_001497, KBio2_004065, KBio2_006633, KBio3_001607, MSK5738, NORFLOXACIN [ORANGE BOOK], NINDS_000084, GLXC-20579, HMS1568N03, HMS1920B16, HMS2090F03, HMS2091J16, HMS2095N03, HMS2235G03, HMS3712N03, HMS5087E17, NORFLOXACIN [EP MONOGRAPH], NORFLOXACIN [USP IMPURITY], Pharmakon1600-01500440, ALBB-015911, HY-B0132, RKL10074, Tox21_110682, Tox21_113441, BBL005569, BDBM50045000, CCG-40235, EBC-04415, MSK5738-100M, NSC757250, s1509, SBB012542, STK177250, AKOS000417391, Norfloxacin for system suitability CRS, Norfloxacin, Pefloxacin EP Impurity A, Tox21_110682_1, AC-6855, AN26450, CS-1906, DB01059, KS-5007, Norfloxacin for peak identification CRS, NSC 757250, 1-ethyl-6-fluoro-7-(1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, IDI1_000084, SMP1_000216, NCGC00016916-02, NCGC00016916-03, NCGC00016916-04, NCGC00016916-05, NCGC00016916-06, NCGC00016916-07, NCGC00016916-08, NCGC00016916-11, NCGC00016916-12, NCGC00021725-03, NCGC00021725-04, ST072202, SY051390, Norfloxacin 100 microg/mL in Acetonitrile, SBI-0051464.P002, N0817, Norfloxacin Solution in Methanol, 100ug/mL, NS00000224, EN300-06467, C06687, D00210, AB00052059-18, AB00052059-19, AB00052059_20, AB00052059_21, Norfloxacin, analytical standard, >=98% (TLC), Norfloxacin, VETRANAL(TM), analytical standard, F370848, Q417897, SR-01000000222-2, SR-01000000222-3, BRD-K11196887-001-05-5, BRD-K11196887-001-15-4, BRD-K11196887-001-20-4, BRD-K11196887-001-21-2, BRD-K11196887-001-22-0, Z56926638, Norfloxacin, British Pharmacopoeia (BP) Reference Standard, Norfloxacin, European Pharmacopoeia (EP) Reference Standard, 1-Ethyl-3-carboxy-6-fluoro-7-(piperazinyl-1)-quinolin-4(1H)-one, Norfloxacin, United States Pharmacopeia (USP) Reference Standard, Norfloxacin, Pharmaceutical Secondary Standard, Certified Reference Material, (NFLX)1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid, 1-ethyl-1,4-dihydro-6-fluoro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid, 1-ethyl-4-oxo-6-fluoro-7-(piperazinyl)-1,4-dihydro-quinoline-3-carboxylic acid, 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid, 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylicAcid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxo-3-quinoline carboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid, 1-Ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid #, 1-Ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydroquinoline-3-carboxylic Acid, 1-ethyl-6-fluoro-7-(1-piperazinyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid, 7-(1-Piperazinyl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, Norfloxacin for peak identification, European Pharmacopoeia (EP) Reference Standard, Norfloxacin for system suitability, European Pharmacopoeia (EP) Reference Standard, (norfloxacin)1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid, 1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4,4a,8a-tetrahydro-quinoline-3-carboxylic acid (norfloxacin), 1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid (Norfloxacin), 1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid(1-norfloxacin), 1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid(Norfloxacin)
Bioactivity: Fluoroquinolone antibiotic; bacterial DNA gyrase and topoisomerase IV inhibitor
Solubility in Different Solvents
| Solvent | Temperature [K] | Crystal form | Solubility [mg/mL] | Reference |
|---|---|---|---|---|
| 1-Octanol | 293.15 | - | 0.1045 | [170] |
| 1-Octanol | 298.15 | - | 0.1335 | [170] |
| 1-Octanol | 303.15 | - | 0.1714 | [170] |
| 1-Octanol | 308.15 | - | 0.2163 | [170] |
| 1-Octanol | 313.15 | - | 0.2795 | [170] |
| 1-Octanol | 318.15 | - | 0.351 | [170] |
| 1-Octanol | 323.15 | - | 0.4404 | [170] |
| 1-Octanol | 328.15 | - | 0.5582 | [170] |
| 1-Octanol | 333.15 | - | 0.6872 | [170] |
| Water | 293.15 | - | 0.3578 | [169] |
| Water | 298.15 | - | 0.4012 | [169] |
| Water | 303.15 | - | 0.4485 | [169] |
| Water | 308.15 | - | 0.5136 | [169] |
| Water | 313.15 | - | 0.594 | [169] |
| Water | 318.15 | - | 0.6895 | [169] |
| Water | 323.15 | - | 0.8214 | [169] |
Molecule 3D descriptors
| Descriptor | Value |
|---|---|
| PMI1 | 892.5001 |
| PMI2 | 3964.0337 |
| PMI3 | 4735.2971 |
| NPR1 | 0.1885 |
| NPR2 | 0.8371 |
| RadiusOfGyration | 3.8754 |
| InertialShapeFactor | 0.0009 |
| Eccentricity | 0.9821 |
| Asphericity | 0.5390 |
| SpherocityIndex | 0.0957 |
| PBF | 0.5750 |