Lorazepam

A benzodiazepine drug with anxiolytic, sedative, hypnotic, anticonvulsant, and muscle-relaxant properties. It acts as a positive allosteric modulator of GABA-A receptors, enhancing the inhibitory effects of GABA in the central nervous system. It is used primarily for the treatment of anxiety disorders, acute seizures and status epilepticus, and for sedation.

Compound Structure

CAS Number: 846-49-1

Molecular Mass: 321.2 g/mol

Formula: C15H10Cl2N2O2

Smiles: O=C1Nc2ccc(Cl)cc2C(c2ccccc2Cl)=NC1O

Synonymes:

Bioactivity: Benzodiazepine; positive allosteric modulator of GABA-A receptors

Solubility in Different Solvents

Solvent Temperature [K] Crystal form Solubility [mg/mL] Reference
Water 303.2 - 0.053 [405]

Molecule 3D descriptors

Descriptor Value
PMI1 1785.5811
PMI2 1959.4623
PMI3 2844.4448
NPR1 0.6277
NPR2 0.6889
RadiusOfGyration 3.2029
InertialShapeFactor 0.0004
Eccentricity 0.7784
Asphericity 0.0891
SpherocityIndex 0.3577
PBF 0.9810