Lorazepam
A benzodiazepine drug with anxiolytic, sedative, hypnotic, anticonvulsant, and muscle-relaxant properties. It acts as a positive allosteric modulator of GABA-A receptors, enhancing the inhibitory effects of GABA in the central nervous system. It is used primarily for the treatment of anxiety disorders, acute seizures and status epilepticus, and for sedation.
CAS Number: 846-49-1
Molecular Mass: 321.2 g/mol
Formula: C15H10Cl2N2O2
Smiles: O=C1Nc2ccc(Cl)cc2C(c2ccccc2Cl)=NC1O
Synonymes:
Lorazepam, lorazepam, Ativan, 846-49-1, Temesta, Loraz, Wypax, Almazine, Anxiedin, Lorabenz, Orfidal, Lorazepam Intensol, Wy-4036, Lorazepamum, Wy 4036, 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one, Lorazepam preservative free, Lorazepam civ, 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-, DTXSID7023225, 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one, O26FZP769L, LOREEV XR, NSC289758, DTXCID303225, Durazolam, Apo Lorazepam, Orfidal Wyeth, Novo Lorazem, Wyeth, Orfidal, 7-chloro-5-(2-chlorophenyl)-3-hydroxy-2,3-dihydro-1H-1,4-benzodiazepin-2-one, Medical, Lorazepam, Lorazepam ratiopharm, Lorazepam neuraxpharm, Von Ct, Lorazep, WY4036, Abbloraz, RefChem:5962, N05BA06, (3RS)-7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one, 7-Chloro-5-(2-chlorophenyl)-1, 3-Dihydro-3-Hydroxy-1,4-Benzodiazepin-2-one, 212-687-6, (+-)-Lorazepam, o-Chloroxazepam, o-Chlorooxazepam, Emotival, Tavor, Delormetazepam, Norlormetazepam, Bonatranquan, Duralozam, Rocosgen, Sedatival, Laubeel, Punktyl, Lorax, Quait, Apo-Lorazepam, Anzepam, Aplacasse, Azurogen, Efasedan, Equitam, Kalmalin, Larpose, Lorapam, Lorazene, Lorazep, Lorazin, Lorenin, Loridem, Lorsedal, Lozepam, Novhepar, Renaquil, Sedizepan, Sidenar, Silence, Tranqipam, Anxira, Aripax, Bonton, Loram, Lorat, Merlit, Stapam, Trapax, Upan, Nervistop L, Demethyllormetazepam, (+/-)-Lorazepam, 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one, NSC 289758, Idalprem, Aplacassee, Sinestron, Donix, Tolid, CHEMBL580, 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one, Lorazepam Medical, Nu Loraz, Nervistopl, Novolorazem, Emotion, Lomesta, Lorafen, Lorazon, Lorivan, Somagerol, Vigiten, Lorans, Lorzem, Lopam, Lorazepam Fabra, Lorazepam-Efeka, Lorazepan Chobet, Lorazepan Richet, Max Pax, Lorazepam Genericon, Lorazepam Lannacher, NSC-289758, NCGC00159439-02, Lorsilan, Securit, Sedazin, Pro dorm, 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-, Lorazepamum [INN-Latin], 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one, Lorazepam (1.0 mg/mL in Acetonitrile), Lorazepam (100 ug/mL in Acetonitrile), Ativan (TN), EINECS 212-687-6, BRN 0759084, UNII-O26FZP769L, DEA No. 2885, Lorazepam [USAN:USP:INN:BAN:JAN], LORAZEPAM [INN], LORAZEPAM [JAN], LORAZEPAM [MI], LORAZEPAM [USAN], (.+/-.)-Lorazepam, LORAZEPAM [VANDF], Lorazepam CRS - * psy, LORAZEPAM [MART.], LORAZEPAM [WHO-DD], (+-)-7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one, SCHEMBL26961, 5-25-02-00248 (Beilstein Handbook Reference), MLS001424236, DivK1c_000965, Lorazepam (JP18/USP/INN), CHEBI:6539, GTPL5884, LORAZEPAM [EP IMPURITY], LORAZEPAM [ORANGE BOOK], LORAZEPAM CIV [USP-RS], LORAZEPAM [EP MONOGRAPH], SCHEMBL29358033, SCHEMBL29388543, SCHEMBL29516559, HMS503A11, KBio1_000965, LORAZEPAM [USP MONOGRAPH], NINDS_000965, HMS2052H07, HMS3394H07, Lorazepam, 1mg/ml in Acetonitrile, Tox21_111669, BDBM50292627, Lorazepam 0.1 mg/ml in Acetonitrile, Lorazepam 1.0 mg/ml in Acetonitrile, AKOS015904303, CCG-101170, DB00186, FL24937, NC00420, 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-, (+-)-, IDI1_000965, CAS-846-49-1, FL181075, SMR000058410, WLN: T67 GMV JN IHJ CG IQ KR BG, NS00000034, D00365, Q408265, 7-Chloro-5-(o-chlorophenyl)-1,4-benzodiazepin-2-one, BRD-A11990600-001-01-8, BRD-A11990600-001-03-4, Lorazepam, British Pharmacopoeia (BP) Reference Standard, Lorazepam for system suitability CRS - * psy (Lorazepam), Lorazepam, European Pharmacopoeia (EP) Reference Standard, 2H-1, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-, 2H-1, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-, Lorazepam, United States Pharmacopeia (USP) Reference Standard, 7-chloro-3-hydroxy-5-(2'-chloro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one, 7-chloro-3-hydroxy-5-(2'-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one, 7-Chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one, 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one #, 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-benzo[e][1,4]diazepin-2(3H)-one, Lorazepam for system suitability, European Pharmacopoeia (EP) Reference Standard, LORAZEPAM7-Chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one, (+/-)-7-CHLORO-5-(O-CHLOROPHENYL)-1,3-DIHYDRO-3-HYDROXY-2H-1,4-BENZODIAZEPIN-2-ONE, (RS)-9-chloro-6-(2-chlorophenyl)-4-hydroxy-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one, 2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-5-(2-CHLOROPHENYL)-1,3-DIHYDRO-3-HYDROXY-, (+/-)-, 7-Chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one (lorazepam)
Bioactivity: Benzodiazepine; positive allosteric modulator of GABA-A receptors
Solubility in Different Solvents
Molecule 3D descriptors
| Descriptor | Value |
|---|---|
| PMI1 | 1785.5811 |
| PMI2 | 1959.4623 |
| PMI3 | 2844.4448 |
| NPR1 | 0.6277 |
| NPR2 | 0.6889 |
| RadiusOfGyration | 3.2029 |
| InertialShapeFactor | 0.0004 |
| Eccentricity | 0.7784 |
| Asphericity | 0.0891 |
| SpherocityIndex | 0.3577 |
| PBF | 0.9810 |