Perphenazine

A phenothiazine typical antipsychotic used primarily for the treatment of schizophrenia and other psychotic disorders, and for the control of severe nausea and vomiting. Its therapeutic effects are mediated predominantly through antagonism of dopamine D2 receptors in the central nervous system

Compound Structure

CAS Number: 58-39-9

Molecular Mass: 404.0 g/mol

Formula: C21H26ClN3OS

Smiles: OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1

Synonymes:

Bioactivity: Typical antipsychotic; dopamine D2 receptor antagonist

Solubility in Different Solvents

Solvent Temperature [K] Crystal form Solubility [mg/mL] Reference
1-Butanol 278.15 - 50.39 [482]
1-Butanol 283.15 - 63.42 [482]
1-Butanol 288.15 - 79.88 [482]
1-Butanol 293.15 - 104.8 [482]
1-Butanol 298.15 - 154.9 [482]
1-Butanol 303.15 - 212.2 [482]
1-Butanol 308.15 - 307.6 [482]
1-Butanol 313.15 - 427.3 [482]
1-Butanol 318.15 - 618.9 [482]
1-Propanol 278.15 - 51.11 [482]
1-Propanol 283.15 - 64.91 [482]
1-Propanol 288.15 - 83.7 [482]
1-Propanol 293.15 - 108.5 [482]
1-Propanol 298.15 - 172.7 [482]
1-Propanol 303.15 - 242.7 [482]
1-Propanol 308.15 - 341.7 [482]
1-Propanol 313.15 - 488.0 [482]
1-Propanol 318.15 - 745.1 [482]
2-Methoxyethanol 278.15 - 253.7 [482]
2-Methoxyethanol 283.15 - 290.5 [482]
2-Methoxyethanol 288.15 - 337.2 [482]
2-Methoxyethanol 293.15 - 399.2 [482]
2-Methoxyethanol 298.15 - 476.5 [482]
2-Methoxyethanol 303.15 - 569.0 [482]
2-Methoxyethanol 308.15 - 702.5 [482]
2-Methoxyethanol 313.15 - 851.5 [482]
2-Methoxyethanol 318.15 - 1065.1 [482]
Acetone 278.15 - 22.66 [482]
Acetone 283.15 - 29.67 [482]
Acetone 288.15 - 38.02 [482]
Acetone 293.15 - 48.65 [482]
Acetone 298.15 - 65.74 [482]
Acetone 303.15 - 85.05 [482]
Acetone 308.15 - 129.8 [482]
Acetone 313.15 - 174.0 [482]
Acetone 318.15 - 245.7 [482]
Amyl Acetate 278.15 - 27.06 [482]
Amyl Acetate 283.15 - 33.27 [482]
Amyl Acetate 288.15 - 40.32 [482]
Amyl Acetate 293.15 - 48.89 [482]
Amyl Acetate 298.15 - 60.06 [482]
Amyl Acetate 303.15 - 73.6 [482]
Amyl Acetate 308.15 - 92.25 [482]
Amyl Acetate 313.15 - 117.5 [482]
Amyl Acetate 318.15 - 155.6 [482]
Dimethylacetamide 278.15 - 279.8 [482]
Dimethylacetamide 283.15 - 327.3 [482]
Dimethylacetamide 288.15 - 383.2 [482]
Dimethylacetamide 293.15 - 451.1 [482]
Dimethylacetamide 298.15 - 525.1 [482]
Dimethylacetamide 303.15 - 609.3 [482]
Dimethylacetamide 308.15 - 717.7 [482]
Dimethylacetamide 313.15 - 843.8 [482]
Dimethylacetamide 318.15 - 995.4 [482]
Dimethylformamide 278.15 - 130.4 [482]
Dimethylformamide 283.15 - 162.5 [482]
Dimethylformamide 288.15 - 202.2 [482]
Dimethylformamide 293.15 - 250.7 [482]
Dimethylformamide 298.15 - 316.1 [482]
Dimethylformamide 303.15 - 395.3 [482]
Dimethylformamide 308.15 - 499.1 [482]
Dimethylformamide 313.15 - 620.5 [482]
Dimethylformamide 318.15 - 770.4 [482]
Ethyl acetate 278.15 - 24.44 [482]
Ethyl acetate 283.15 - 29.64 [482]
Ethyl acetate 288.15 - 40.21 [482]
Ethyl acetate 293.15 - 49.55 [482]
Ethyl acetate 298.15 - 63.09 [482]
Ethyl acetate 303.15 - 80.86 [482]
Ethyl acetate 308.15 - 103.8 [482]
Ethyl acetate 313.15 - 138.1 [482]
Ethyl acetate 318.15 - 192.7 [482]
Glycol monoethyl ether 278.15 - 215.6 [482]
Glycol monoethyl ether 283.15 - 250.4 [482]
Glycol monoethyl ether 288.15 - 282.9 [482]
Glycol monoethyl ether 293.15 - 339.1 [482]
Glycol monoethyl ether 298.15 - 396.4 [482]
Glycol monoethyl ether 303.15 - 469.0 [482]
Glycol monoethyl ether 308.15 - 578.8 [482]
Glycol monoethyl ether 313.15 - 699.6 [482]
Glycol monoethyl ether 318.15 - 872.9 [482]
Methyl acetate 278.15 - 22.37 [482]
Methyl acetate 283.15 - 27.8 [482]
Methyl acetate 288.15 - 36.11 [482]
Methyl acetate 293.15 - 46.11 [482]
Methyl acetate 298.15 - 60.33 [482]
Methyl acetate 303.15 - 80.82 [482]
Methyl acetate 308.15 - 114.6 [482]
Methyl acetate 313.15 - 157.0 [482]
Methyl acetate 318.15 - 218.0 [482]
Propyl acetate 278.15 - 29.55 [482]
Propyl acetate 283.15 - 37.28 [482]
Propyl acetate 288.15 - 45.75 [482]
Propyl acetate 293.15 - 57.59 [482]
Propyl acetate 298.15 - 70.15 [482]
Propyl acetate 303.15 - 88.04 [482]
Propyl acetate 308.15 - 113.6 [482]
Propyl acetate 313.15 - 146.6 [482]
Propyl acetate 318.15 - 197.2 [482]

Molecule 3D descriptors

Descriptor Value
PMI1 2150.5928
PMI2 6995.1103
PMI3 8879.6877
NPR1 0.2422
NPR2 0.7878
RadiusOfGyration 4.7233
InertialShapeFactor 0.0004
Eccentricity 0.9702
Asphericity 0.4451
SpherocityIndex 0.1105
PBF 0.6676