Perphenazine
A phenothiazine typical antipsychotic used primarily for the treatment of schizophrenia and other psychotic disorders, and for the control of severe nausea and vomiting. Its therapeutic effects are mediated predominantly through antagonism of dopamine D2 receptors in the central nervous system
CAS Number: 58-39-9
Molecular Mass: 404.0 g/mol
Formula: C21H26ClN3OS
Smiles: OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1
Synonymes:
Perphenazine, perphenazine, 58-39-9, Trilafon, Perphenazin, Perfenazine, Etaperazine, Chlorpiprazine, Etaperazin, Ethaperazine, Fentazin, Decentan, Perphenan, Perfenazina, Thilatazin, Trifaron, Chlorperphenazine, Triphenot, Emesinal, Trilifan, Perphenazinum, Sch 3940, 2-(4-(3-(2-Chloro-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanol, 2-[4-[3-(2-Chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol, 4-[3-(2-Chlorophenothiazin-10-yl)propyl]-1-piperazineethanol, DTXSID1023441, FTA7XXY4EZ, gamma-(4-(beta-Hydroxyethyl)piperazin-1-yl)propyl-2-chlorophenothiazine, 4-(3-(2-Chlorophenothiazin-10-yl)propyl)-1-piperazineethanol, 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol, NSC-150866, 2-Chloro-10-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)phenothiazine, 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethan-1-ol, NSC150866, 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethanol, 2-Chloro-10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazine, CHEBI:8028, DTXCID703441, 1-Piperazineethanol, 4-(3-(2-chlorophenothiazin-10-yl)propyl)-, Piperazineethanol, 4-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)-, 2-(4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl)ethanol, 1-Piperazineethanol, 4-[3-(2-chlorophenothiazin-10-yl)propyl]-, 2-(4-(3-(2-chlorophenothiazin-10-yl)propyl)piperazin-1-yl)ethanol, 4-(3-(2-Chloro-10H-phenothiazin-10-yl)propyl)-1-piperazineethanol, Piperazineethanol, 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-, Trilafon-La, 2-(4-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)-1-piperazinyl)ethanol, 2-(4-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethan-1-ol, RefChem:55835, N05AB03, 200-381-5, Tranquisan, F-mon, C21H26ClN3OS, MFCD00056798, PZC, 1-(2-Hydroxyethyl)-4-(3-(2-chloro-10-phenothiazinyl)propyl)piperazine, NSC 150866, CHEMBL567, 2-Chloro-10-3-(1-(2-hydroxyethyl)-4-piperazinyl)propyl phenothiazine, MLS000069637, 1',1-(2-Idrossietil)-4,3-(2-cloro-10-fenotiazil)propilpiperazina, 1-Piperazineethanol, 4-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)-, 1-Piperazineethanol, 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-, s4731, CAS-58-39-9, NCGC00015826-02, Perfenil, SMR000058180, Perfenazina [Italian], 1-(2-Hydroxyethyl)-4-[3-(2-chloro-10-phenothiazinyl)propyl]piperazine, Perfenazina [INN-Spanish], Perphenazinum [INN-Latin], 2-Chloro-10-3-[1-(2-hydroxyethyl)-4-piperazinyl]propyl phenothiazine, HSDB 3379, SR-01000000137, UNII-FTA7XXY4EZ, EINECS 200-381-5, 2-{4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazinyl}ethan-1-ol, AI3-50151, Perphenazine CRS, .gamma.-(4-(.beta.-Hydroxyethyl)piperazin-1-yl)propyl-2-chlorophenothiazine, .gamma.-[4-(.beta.-Hydroxyethyl)piperazin-1-yl]propyl-2-chlorophenothiazine, Perphenazine [USP:INN:BAN:JAN], 2-Chloro-10-(3-(1-(2-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine, SCH-3940, Prestwick_536, 1',1-(2-Idrossietil)-4,3-(2-cloro-10-fenotiazil)propilpiperazina [Italian], Etrafon (Salt/Mix), 2-(4-{3-[2-Chloro(1,4,6,9-~2~H_4_)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethan-1-ol, Hydroxymet hylferrocene, PS16 - Perphenazine, Spectrum_001610, Perphenazine (Standard), Opera_ID_1161, Prestwick0_000125, Prestwick1_000125, Prestwick2_000125, Prestwick3_000125, Spectrum2_001602, Spectrum3_000758, Spectrum4_000843, Spectrum5_001493, Lopac-P-6402, PERPHENAZINE [MI], PERPHENAZINE [INN], PERPHENAZINE [JAN], P 6402, PERPHENAZINE [HSDB], PERPHENAZINE [VANDF], Lopac0_000930, Oprea1_603835, REGID_for_CID_4748, SCHEMBL42125, BSPBio_000170, BSPBio_002376, GTPL209, KBioGR_001445, KBioSS_002090, PERPHENAZINE [MART.], MLS001146929, MLS002548897, BIDD:GT0150, DivK1c_000880, PERPHENAZINE [USP-RS], PERPHENAZINE [WHO-DD], SPECTRUM1503934, SPBio_001603, SPBio_002109, BPBio1_000188, orb1309806, orb3025210, SCHEMBL29385591, SCHEMBL29461866, component of Triavil (Salt/Mix), HMS502L22, HY-A0077R, KBio1_000880, KBio2_002090, KBio2_004658, KBio2_007226, KBio3_001596, Perphenazine (JP17/USP/INN), NINDS_000880, GLXC-06105, HMS1568I12, HMS1922M14, HMS2093M15, HMS2095I12, HMS2232D21, HMS3259C09, HMS3262J22, HMS3370O14, HMS3712I12, HMS3885H20, HMS5083G22, PERPHENAZINE [ORANGE BOOK], Pharmakon1600-01503934, PERPHENAZINE [EP MONOGRAPH], HY-A0077, MSK11438, PERPHENAZINE [USP MONOGRAPH], Perphenazine 1.0 mg/ml in Methanol, Tox21_110233, Tox21_500930, 1-Piperazineethanol, trihydrochloride, BDBM50130273, CCG-39060, EBC-00669, NSC758649, SBB037866, STK019818, AKOS000664046, Tox21_110233_1, CS-5137, DB00850, ETRAFON-A COMPONENT PERPHENAZINE, KS-5105, LP00930, NC00472, NSC-758649, Perphenazine for system suitability CRS, SDCCGSBI-0050904.P004, IDI1_000880, MRF-0000509, NCGC00015826-01, NCGC00015826-03, NCGC00015826-04, NCGC00015826-05, NCGC00015826-06, NCGC00015826-07, NCGC00015826-08, NCGC00015826-09, NCGC00015826-10, NCGC00015826-13, NCGC00015826-20, NCGC00024092-03, NCGC00024092-04, NCGC00024092-05, NCGC00024092-06, NCGC00261615-01, AC-12196, ST079662, SBI-0050904.P003, DB-053200, AB00052390, EU-0072164, EU-0100930, NS00006492, P1970, C07427, D00503, D82041, EN300-120640, AB00052390_17, F094523, L000919, Q423520, SR-01000000137-2, SR-01000000137-4, SR-01000000137-5, SR-01000000137-8, BRD-K10995081-001-05-5, BRD-K10995081-001-15-4, BRD-K10995081-001-26-1, BRD-K10995081-001-27-9, BRD-K10995081-001-28-7, WLN: T C666 BN ISJ EG B3- AT6N DNTJ D2Q, Z1530532754, Perphenazine, British Pharmacopoeia (BP) Reference Standard, FLUPHENAZINE DIHYDROCHLORIDE IMPURITY E [EP IMPURITY], Perphenazine, European Pharmacopoeia (EP) Reference Standard, Perphenazine, United States Pharmacopeia (USP) Reference Standard, phenothiazine, 2-chloro-10-[N-(2-hydroxy)ethyl]piperazinylpropyl-, 2-[4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]piperazin- 1-yl]ethanol, 2-[4-[3-(2-Chlorophenothiazin-10-yl)propyl]-piperazin-1-yl]ethanol, 2-(4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl)ethanol #, Perphenazine for system suitability, European Pharmacopoeia (EP) Reference Standard
Bioactivity: Typical antipsychotic; dopamine D2 receptor antagonist
Solubility in Different Solvents
Molecule 3D descriptors
| Descriptor | Value |
|---|---|
| PMI1 | 2150.5928 |
| PMI2 | 6995.1103 |
| PMI3 | 8879.6877 |
| NPR1 | 0.2422 |
| NPR2 | 0.7878 |
| RadiusOfGyration | 4.7233 |
| InertialShapeFactor | 0.0004 |
| Eccentricity | 0.9702 |
| Asphericity | 0.4451 |
| SpherocityIndex | 0.1105 |
| PBF | 0.6676 |