Dofetilide

Molecular Mass: 441.6 g/mol

Formula: C₁₉H₂₇N₃O₅S₂

Smiles: CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1

Synonymes:

Dofetilide, 115256-11-6, Tikosyn, Dofetilida, Dofetilidum, UK-68,798, UK-68798, DTXSID5046433, R4Z9X1N2ND, beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide, Methanesulfonamide, N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-, CHEBI:4681, DTXCID3026433, N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide, Methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl)phenyl)-, 1-MSPMPE, N-(4-{2-[methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methanesulfonamide, N-(4-(2-(2-(4-methanesulfonamidophenyl)ethyl-methylamino)ethoxy)phenyl)methanesulfonamide, N-[4-[2-[2-(4-methanesulfonamidophenyl)ethyl-methylamino]ethoxy]phenyl]methanesulfonamide, Dofetilide 0.5mg, N-(4-(2-((2-(4-methanesulfonamidophenoxy)ethyl)(methyl)amino)ethyl)phenyl)methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide, N-[4-(2-{[2-(4-methanesulfonamidophenoxy)ethyl](methyl)amino}ethyl)phenyl]methanesulfonamide, DOFETILDE, 1-(4-methanesulfonamidophenoxy)-2-(N-(4-methanesulfonamidophenethyl)-N-methylamine)ethane, Dofetilide 0.25mg, Dofetilide 0.125mg, RefChem:57792, C01BD04, Dofetilidum [INN-Latin], Dofetilida [INN-Spanish], UK 68798, N-(4-(2-(methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide, MFCD00869707, C19H27N3O5S2, CHEMBL473, N-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methylamino]ethyl]phenyl]methanesulfonamide, 1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane, NCGC00164549-01, Dofetilide (>90%), N-[4-(2-{[2-(4-methanesulfonamidophenyl)ethyl](methyl)amino}ethoxy)phenyl]methanesulfonamide, N-[4-(2-{2-[4-(methanesulphonamido)phenoxyl]-N-methylethylamino}ethyl)phenyl]-methanesulphonamide, Xelide, SMR000466333, Tikosyn (TN), CAS-115256-11-6, UK 68,798, UNII-R4Z9X1N2ND, HSDB 7927, N-[4-[2-[Methyl[2-[4-(methylsulfonamido)phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide, IXTMWRCNAAVVAI-UHFFFAOYSA-N, Dofetilide [USAN:USP:INN:BAN], Dofetilide (Tikosyn), UK68798, Dofetilide (Standard), Dofetilide (Tikosyn)?, DOFETILIDE [MI], DOFETILIDE [INN], DOFETILIDE [JAN], DOFETILIDE [USAN], DOFETILIDE [VANDF], DOFETILIDE [MART.], DOFETILIDE [USP-RS], DOFETILIDE [WHO-DD], SCHEMBL16135, Dofetilide (JAN/USP/INN), MLS000759442, MLS001424185, MLS006010154, DOFETILIDE [EMA EPAR], Dofetilide - Bio-X trade mark, GTPL2604, orb1300735, DOFETILIDE [ORANGE BOOK], Dofetilide, >=98% (HPLC), HY-B0232R, DOFETILIDE [USP MONOGRAPH], GLXC-05217, HMS2051N14, HMS2089F03, HMS2232H19, HMS3261G03, HMS3370B18, HMS3393N14, HMS3655A17, HMS3715H20, HMS5079J08, HY-B0232, Tox21_112178, Tox21_500351, AC-385, BDBM50031720, EBC-11239, HB1078, NSC786034, s1658, AKOS005259921, Tox21_112178_1, CCG-101037, DB00204, FD09968, NC00287, NSC-786034, UK68789, MRF-0000317, N-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methyl-amino]ethyl]phenyl]methanesulfonamide, NCGC00164549-02, NCGC00261036-01, BD164377, SY227006, UK 68789, DB-041252, NS00068338, SW197667-2, C07751, D00647, H11953, AB00639976-06, AB00639976-08, AB00639976_09, EN300-19768191, F819018, SR-01000759368, 11W-0619, Q3712521, SR-01000759368-4, BRD-K86887724-001-05-6, BRD-K86887724-001-09-8, BRD-K86887724-001-10-6, Dofetilide, United States Pharmacopeia (USP) Reference Standard, .BETA.-((P-METHANESULFONAMIDOPHENETHYL)METHYLAMINO)METHANESULFONO-P-PHENETIDIDE, 1-(4-Methansulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane, (Dofetilide) N-[4-(2-{[2-(4-Methanesulfonylamino-phenyl)-ethyl]-methylamino}-ethoxy)-phenyl]-methanesulfonamide, N-(4-{2-[{2-[4-(Methanesulfonamido)phenoxy]ethyl}(methyl)amino]ethyl}phenyl)methanesulfonamide, N-[4-(2-{[2-(4-methanesulfonylamino-phenoxy)-ethyl]-methyl-amino}-ethyl)-phenyl]-methanesulfonamide, N-[4-(2-{[2-(4-Methanesulfonylamino-phenyl)-ethyl]-methyl-amino}-ethoxy)-phenyl]-methanesulfonamide (dofetilide), N-[4-(2-{[2-(4-Methanesulfonylamino-phenyl)-ethyl]-methyl-amino}-ethoxy)-phenyl]-methanesulfonamide (UK-68798), N-[4-(2-{[2-(4-METHANESULFONYLAMINO-PHENYL)-ETHYL]-METHYL-AMINO}-ETHOXY)-PHENYL]-METHANESULFONAMIDE DOFETILIDE, N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-methanesulfonamide, UK-68798, Tikosyn,

Bioactivity: -

Solubility in Different Solvents

Solvent	Temperature [K]	Crystal form	Solubility [mg/mL]	Reference
1-Octanol	293.15	-	0.1382	[493]
1-Octanol	298.15	-	0.1993	[493]
1-Octanol	303.15	-	0.2797	[493]
1-Octanol	308.15	-	0.4016	[493]
1-Octanol	313.15	-	0.5346	[493]
Hexane	293.15	-	0.0011	[493]
Hexane	298.15	-	0.0013	[493]
Hexane	303.15	-	0.0017	[493]
Hexane	308.15	-	0.002	[493]
Hexane	313.15	-	0.0024	[493]

Molecule 3D descriptors

Descriptor	Value
PMI1	1060.3914
PMI2	19898.3417
PMI3	20499.4494
NPR1	0.0517
NPR2	0.9707
RadiusOfGyration	6.8515
InertialShapeFactor	0.0009
Eccentricity	0.9987
Asphericity	0.8531
SpherocityIndex	0.0478
PBF	0.6543