Risperidone

A second-generation atypical antipsychotic used for the treatment of schizophrenia, bipolar I disorder-associated manic or mixed episodes, and irritability associated with autistic disorder. Risperidone primarily antagonizes dopamine D₂ and serotonin 5-HT₂A receptors and also exhibits affinity for α₁-adrenergic and histamine H₁ receptors. Its major active metabolite is paliperidone (9-hydroxyrisperidone)

Compound Structure

CAS Number: 106266-06-2

Molecular Mass: 410.5 g/mol

Formula: C23H27FN4O2

Smiles: Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2

Synonymes:

Bioactivity: Atypical antipsychotic; dopamine D₂ and serotonin 5-HT₂A receptor antagonist

Solubility in Different Solvents

Solvent Temperature [K] Crystal form Solubility [mg/mL] Reference
1-Butanol 278.15 - 6.922 [56]
1-Butanol 278.15 - 6.557 [58]
1-Butanol 283.15 - 7.844 [56]
1-Butanol 283.15 - 8.28 [58]
1-Butanol 288.15 - 9.93 [56]
1-Butanol 288.15 - 10.14 [58]
1-Butanol 293.15 - 11.82 [56]
1-Butanol 293.15 - 13.1 [58]
1-Butanol 298.15 - 15.54 [56]
1-Butanol 298.15 - 16.49 [58]
1-Butanol 303.15 - 19.75 [56]
1-Butanol 303.15 - 21.37 [58]
1-Butanol 308.15 - 26.37 [56]
1-Butanol 308.15 - 27.61 [58]
1-Butanol 313.15 - 33.38 [56]
1-Butanol 313.15 - 35.12 [58]
1-Butanol 318.15 - 42.57 [56]
1-Butanol 323.15 - 54.75 [56]
1-Propanol 278.15 - 7.758 [56]
1-Propanol 278.15 - 6.194 [58]
1-Propanol 283.15 - 8.609 [56]
1-Propanol 283.15 - 8.298 [58]
1-Propanol 288.15 - 10.89 [56]
1-Propanol 288.15 - 10.99 [58]
1-Propanol 293.15 - 13.08 [56]
1-Propanol 293.15 - 13.67 [58]
1-Propanol 298.15 - 16.7 [56]
1-Propanol 298.15 - 16.96 [58]
1-Propanol 303.15 - 20.79 [56]
1-Propanol 303.15 - 22.32 [58]
1-Propanol 308.15 - 28.1 [56]
1-Propanol 308.15 - 28.9 [58]
1-Propanol 313.15 - 35.25 [56]
1-Propanol 313.15 - 37.01 [58]
1-Propanol 318.15 - 45.27 [56]
1-Propanol 323.15 - 58.59 [56]
2-Butanol 278.15 - 8.518 [58]
2-Butanol 283.15 - 11.02 [58]
2-Butanol 288.15 - 12.88 [58]
2-Butanol 293.15 - 16.18 [58]
2-Butanol 298.15 - 20.71 [58]
2-Butanol 303.15 - 26.84 [58]
2-Butanol 308.15 - 34.09 [58]
2-Butanol 313.15 - 43.58 [58]
Acetone 278.15 - 4.85 [56]
Acetone 278.15 - 4.392 [58]
Acetone 283.15 - 5.39 [56]
Acetone 283.15 - 6.316 [58]
Acetone 288.15 - 7.157 [56]
Acetone 288.15 - 7.592 [58]
Acetone 293.15 - 7.997 [56]
Acetone 293.15 - 9.257 [58]
Acetone 298.15 - 9.747 [56]
Acetone 298.15 - 11.56 [58]
Acetone 303.15 - 12.08 [56]
Acetone 303.15 - 13.88 [58]
Acetone 308.15 - 15.57 [56]
Acetone 308.15 - 16.92 [58]
Acetone 313.15 - 18.29 [56]
Acetone 313.15 - 21.21 [58]
Acetone 318.15 - 22.53 [56]
Acetone 323.15 - 27.23 [56]
Butyl acetate 278.15 - 3.551 [58]
Butyl acetate 283.15 - 4.059 [58]
Butyl acetate 288.15 - 4.979 [58]
Butyl acetate 293.15 - 5.911 [58]
Butyl acetate 298.15 - 7.482 [58]
Butyl acetate 303.15 - 8.711 [58]
Butyl acetate 308.15 - 10.47 [58]
Butyl acetate 313.15 - 11.79 [58]
Ethanol 278.15 - 6.87 [56]
Ethanol 278.15 - 6.271 [58]
Ethanol 283.15 - 7.684 [56]
Ethanol 283.15 - 7.463 [57]
Ethanol 283.15 - 7.584 [58]
Ethanol 283.16 - 7.412 [57]
Ethanol 288.15 - 9.272 [56]
Ethanol 288.15 - 9.775 [57]
Ethanol 288.15 - 9.407 [58]
Ethanol 288.16 - 9.79 [57]
Ethanol 293.15 - 10.78 [56]
Ethanol 293.15 - 11.96 [57]
Ethanol 293.15 - 11.02 [58]
Ethanol 293.16 - 11.97 [57]
Ethanol 298.15 - 14.09 [56]
Ethanol 298.15 - 15.16 [57]
Ethanol 298.15 - 14.66 [58]
Ethanol 303.15 - 17.3 [56]
Ethanol 303.15 - 19.0 [57]
Ethanol 303.15 - 18.05 [58]
Ethanol 308.15 - 22.9 [56]
Ethanol 308.15 - 24.33 [57]
Ethanol 308.15 - 23.14 [58]
Ethanol 313.15 - 28.68 [56]
Ethanol 313.15 - 30.25 [57]
Ethanol 313.15 - 29.52 [58]
Ethanol 318.15 - 35.1 [56]
Ethanol 323.15 - 46.35 [56]
Ethyl acetate 278.15 - 4.97 [56]
Ethyl acetate 278.15 - 4.841 [58]
Ethyl acetate 283.15 - 5.451 [56]
Ethyl acetate 283.15 - 6.146 [58]
Ethyl acetate 288.15 - 7.082 [56]
Ethyl acetate 288.15 - 6.984 [58]
Ethyl acetate 293.15 - 7.776 [56]
Ethyl acetate 293.15 - 8.715 [58]
Ethyl acetate 298.15 - 9.021 [56]
Ethyl acetate 298.15 - 10.36 [58]
Ethyl acetate 303.15 - 10.91 [56]
Ethyl acetate 303.15 - 12.35 [58]
Ethyl acetate 308.15 - 13.65 [56]
Ethyl acetate 308.15 - 15.41 [58]
Ethyl acetate 313.15 - 16.28 [56]
Ethyl acetate 313.15 - 19.02 [58]
Ethyl acetate 318.15 - 19.75 [56]
Ethyl acetate 323.15 - 23.5 [56]
Isobutyl Acetate 278.15 - 2.485 [58]
Isobutyl Acetate 283.15 - 3.304 [58]
Isobutyl Acetate 288.15 - 3.997 [58]
Isobutyl Acetate 293.15 - 4.644 [58]
Isobutyl Acetate 298.15 - 5.616 [58]
Isobutyl Acetate 303.15 - 6.895 [58]
Isobutyl Acetate 308.15 - 8.08 [58]
Isobutyl Acetate 313.15 - 9.972 [58]
Isopropanol 278.15 - 1.96 [56]
Isopropanol 278.15 - 2.57 [58]
Isopropanol 283.15 - 2.5 [56]
Isopropanol 283.15 - 3.3 [58]
Isopropanol 288.15 - 3.2 [56]
Isopropanol 288.15 - 3.855 [58]
Isopropanol 293.15 - 3.8 [56]
Isopropanol 293.15 - 4.581 [58]
Isopropanol 298.15 - 5.501 [56]
Isopropanol 298.15 - 5.902 [58]
Isopropanol 303.15 - 7.228 [56]
Isopropanol 303.15 - 7.116 [58]
Isopropanol 308.15 - 10.74 [56]
Isopropanol 308.15 - 10.21 [58]
Isopropanol 313.15 - 13.31 [56]
Isopropanol 313.15 - 14.28 [58]
Isopropanol 318.15 - 16.7 [56]
Isopropanol 323.15 - 23.31 [56]
Methanol 278.15 - 20.88 [56]
Methanol 278.15 - 21.05 [58]
Methanol 283.15 - 23.6 [56]
Methanol 283.15 - 24.52 [57]
Methanol 283.15 - 23.28 [58]
Methanol 283.16 - 24.54 [57]
Methanol 288.15 - 27.8 [56]
Methanol 288.15 - 30.07 [57]
Methanol 288.15 - 27.88 [58]
Methanol 288.16 - 30.08 [57]
Methanol 293.15 - 33.4 [56]
Methanol 293.15 - 36.88 [57]
Methanol 293.15 - 33.66 [58]
Methanol 293.16 - 36.89 [57]
Methanol 298.15 - 40.05 [56]
Methanol 298.15 - 44.81 [57]
Methanol 298.15 - 41.13 [58]
Methanol 298.16 - 44.81 [57]
Methanol 303.15 - 49.01 [56]
Methanol 303.15 - 54.95 [57]
Methanol 303.15 - 50.95 [58]
Methanol 303.16 - 54.95 [57]
Methanol 308.15 - 61.59 [56]
Methanol 308.15 - 67.49 [57]
Methanol 308.15 - 62.38 [58]
Methanol 308.16 - 67.49 [57]
Methanol 313.15 - 76.8 [56]
Methanol 313.15 - 82.77 [57]
Methanol 313.15 - 78.48 [58]
Methanol 313.16 - 82.77 [57]
Methanol 318.15 - 98.3 [56]
Methanol 318.15 - 100.6 [57]
Methanol 318.16 - 100.6 [57]
Methanol 323.15 - 127.0 [56]
Methanol 323.15 - 120.1 [57]
Methanol 323.16 - 120.1 [57]
Methanol 328.15 - 146.0 [57]
Methanol 328.16 - 146.1 [57]
Methyl acetate 278.15 - 6.562 [58]
Methyl acetate 283.15 - 8.067 [58]
Methyl acetate 288.15 - 9.373 [58]
Methyl acetate 293.15 - 11.34 [58]
Methyl acetate 298.15 - 13.6 [58]
Methyl acetate 303.15 - 16.85 [58]
Methyl acetate 308.15 - 20.19 [58]
Methyl acetate 313.15 - 24.71 [58]
Propyl acetate 278.15 - 4.215 [58]
Propyl acetate 283.15 - 5.316 [58]
Propyl acetate 288.15 - 5.982 [58]
Propyl acetate 293.15 - 7.213 [58]
Propyl acetate 298.15 - 8.599 [58]
Propyl acetate 303.15 - 10.2 [58]
Propyl acetate 308.15 - 12.54 [58]
Propyl acetate 313.15 - 14.81 [58]
Toluene 278.15 - 15.0 [56]
Toluene 283.15 - 16.38 [56]
Toluene 288.15 - 20.34 [56]
Toluene 293.15 - 21.71 [56]
Toluene 298.15 - 25.79 [56]
Toluene 303.15 - 31.0 [56]
Toluene 308.15 - 38.3 [56]
Toluene 313.15 - 44.85 [56]
Toluene 318.15 - 53.4 [56]
Toluene 323.15 - 63.39 [56]
Water 283.15 - 0.0011 [57]
Water 283.16 - 0.0011 [57]
Water 288.15 - 0.0014 [57]
Water 288.16 - 0.0014 [57]
Water 293.15 - 0.0019 [57]
Water 293.16 - 0.0019 [57]
Water 298.15 - 0.0024 [57]
Water 298.15 - 0.0023 [59]
Water 298.16 - 0.0024 [57]
Water 303.15 - 0.0031 [57]
Water 303.15 - 0.0023 [59]
Water 303.16 - 0.0031 [57]
Water 308.15 - 0.0041 [57]
Water 308.15 - 0.0045 [59]
Water 308.16 - 0.0041 [57]
Water 313.15 - 0.0054 [57]
Water 313.15 - 0.0045 [59]
Water 313.16 - 0.0054 [57]
Water 318.15 - 0.0066 [57]
Water 318.15 - 0.0068 [59]
Water 318.16 - 0.0066 [57]
Water 323.15 - 0.0086 [57]
Water 323.15 - 0.009 [59]
Water 323.16 - 0.0086 [57]
Water 328.15 - 0.0108 [57]
Water 328.15 - 0.011 [59]
Water 328.16 - 0.0107 [57]
Water 333.15 - 0.013 [59]
isopropyl acetate 278.15 - 2.665 [58]
isopropyl acetate 283.15 - 3.152 [58]
isopropyl acetate 288.15 - 3.593 [58]
isopropyl acetate 293.15 - 4.386 [58]
isopropyl acetate 298.15 - 5.23 [58]
isopropyl acetate 303.15 - 6.451 [58]
isopropyl acetate 308.15 - 7.728 [58]
isopropyl acetate 313.15 - 9.23 [58]

Molecule 3D descriptors

Descriptor Value
PMI1 1013.5399
PMI2 11889.8228
PMI3 12520.9034
NPR1 0.0809
NPR2 0.9496
RadiusOfGyration 5.5649
InertialShapeFactor 0.0009
Eccentricity 0.9967
Asphericity 0.7770
SpherocityIndex 0.0958
PBF 0.7654