Naftopidil

CAS Number: 57149-07-2

Molecular Mass: 392.5 g/mol

Formula: C₂₄H₂₈N₂O₃

Smiles: COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1

Synonymes:

Naftopidil, naftopidil, 57149-07-2, Flivas, Naftopidilum, 1-(4-(2-methoxyphenyl)piperazin-1-yl)-3-(naphthalen-1-yloxy)propan-2-ol, DTXSID5045176, R9PHW59SFN, NSC-759293, DTXCID3025176, 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalen-1-yloxy)propan-2-ol, 1-(4-(2-methoxyphenyl)-1-piperazinyl)-3-(1-naphthyloxy)-2-propanol, 1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphthyloxy)-2-propanol, RefChem:831691, (2RS)-1-(4-(2-Methoxyphenyl)piperazin-1-yl)-3-(naphthalen-1-yloxy)propan-2-ol, Avishot, KT-611, Naftopidil [INN], 4-(2-methoxyphenyl)-alpha-[(1-naphthalenyloxy)methyl]-1-piperazineethanol, MFCD00242741, (+/-)-Naftopidil, BM-15275, CHEMBL142635, NCGC00015718-06, 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(1-naphthyloxy)propan-2-ol, 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol, Naftopidilum [Latin], Naftopidil hydrochloride hydrate, SMR000466346, CAS-57149-07-2, UNII-R9PHW59SFN, BRN 0629965, Avishot, , Flivas (TN), Naftopidil (Flivas), Naftopidil (Standard), NAFTOPIDIL [MI], NAFTOPIDIL [JAN], Prestwick0_000975, Prestwick1_000975, Prestwick2_000975, Prestwick3_000975, (+-)-1-(4-(2-Methoxyphenyl)piperazinyl)-3-(1-naphthyloxy)propan-2-ol, Naftopidil (JP18/INN), (RS)-1-(4-(2-methoxyphenyl)-1-piperazinyl)-3-(1-naphthyloxy)-2-propanol, 4-(2-Methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-1-pioerazineethanol, cid_4418, NAFTOPIDIL [MART.], NAFTOPIDIL [WHO-DD], Lopac0_000941, REGID_for_CID_4418, BSPBio_001009, MLS000759459, MLS001424117, SCHEMBL113215, SPBio_002920, BPBio1_001111, Naftopidil - Bio-X trade mark, orb1310376, SCHEMBL29449978, BDBM50773, CHEBI:31891, cid_6603044, HY-B0391R, HMS2051B09, HMS2089G07, HMS3393B09, HMS3655H21, HMS3884P07, HMS5080K14, Pharmakon1600-01506024, HY-B0391, Tox21_110205, BBL028454, EBC-03851, MFCD11046013, MSK163437, NSC759293, s2126, STL372645, (+-)-4-(o-Methoxyphenyl)-alpha-((1-naphthyloxy)methyl)-1-piperazineethanol, 1-Pioerazineethanol, 4-(2-methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-, AKOS002279617, AKOS016328058, Tox21_110205_1, CCG-100935, CCG-205022, DB12092, FE-0209, FN26123, NC00185, NSC 759293, SB19321, SDCCGSBI-0050915.P003, NCGC00015718-04, NCGC00015718-05, NCGC00015718-08, NCGC00015718-09, NCGC00015718-10, NCGC00015718-12, NCGC00015718-25, NCGC00024672-03, NCGC00024672-04, BN164631, SY053735, SBI-0050915.P002, AB00514643, N0832, ST50794017, SW196570-4, T0696, D01674, AB00489961-18, AB00489961-19, AB00489961_20, AB00489961_21, EN300-6492981, F463444, Q6958243, BRD-A01787639-001-06-4, BRD-A01787639-001-07-2, BRD-A01787639-001-08-0, BRD-A01787639-003-16-9, BRD-A01787639-300-03-7, BRD-A01787639-300-04-5, BRD-A01787639-300-08-6, BRD-A01787639-300-09-4, Z31369389, 1-[4-(2-methoxyphenyl)piperazinyl]-3-naphthyloxypropan-2-ol, 1-[4-(2-Methoxyphenyl)piperazinyl]-3-(1-naphthyloxy)propan-2-ol, 1-[4-(2-methoxyphenyl)piperazino]-3-(1-naphthoxy)propan-2-ol, hydrochloride, 4-(2-Methoxyphenyl)-?-[(1-naphthalenyloxy)methyl]-1-piperazineethanol, (+/-)-4-(O-METHOXYPHENYL)-.ALPHA.-((1-NAPHTHYLOXY)METHYL)-1-PIPERAZINEETHANOL, 1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphthalenyloxy)-2-propanol, hydrochloride, 1-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-[(naphthalen-1-yl)oxy]propan-2-ol, 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxy-propan-2-ol, hydrochloride, 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol, hydrochloride, 4-(2-Methoxyphenyl)-alpha-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrochloride hydrate

Bioactivity: -

Solubility in Different Solvents

Solvent	Temperature [K]	Crystal form	Solubility [mg/mL]	Reference
Acetone	273.15	-	17.54	[111]
Acetone	278.15	-	21.87	[111]
Acetone	283.15	-	26.2	[111]
Acetone	288.15	-	31.33	[111]
Acetone	293.15	-	36.34	[111]
Acetone	298.15	-	41.79	[111]
Acetone	303.15	-	47.52	[111]
Acetone	308.15	-	54.02	[111]
Acetone	313.15	-	61.81	[111]
Acetonitrile	273.15	-	8.677	[111]
Acetonitrile	278.15	-	10.13	[111]
Acetonitrile	283.15	-	11.84	[111]
Acetonitrile	288.15	-	13.7	[111]
Acetonitrile	293.15	-	15.62	[111]
Acetonitrile	298.15	-	18.17	[111]
Acetonitrile	303.15	-	20.68	[111]
Acetonitrile	308.15	-	23.57	[111]
Acetonitrile	313.15	-	27.13	[111]
Dimethyl sulfoxide	293.15	-	160.8	[110]
Dimethyl sulfoxide	298.15	-	183.9	[110]
Dimethyl sulfoxide	303.15	-	208.7	[110]
Dimethyl sulfoxide	308.15	-	236.7	[110]
Dimethyl sulfoxide	313.15	-	266.7	[110]
Dimethyl sulfoxide	318.15	-	300.4	[110]
Dimethyl sulfoxide	323.15	-	337.3	[110]
Dimethyl sulfoxide	328.15	-	378.0	[110]
Ethanol	273.15	-	5.622	[111]
Ethanol	278.15	-	6.537	[111]
Ethanol	283.15	-	7.606	[111]
Ethanol	288.15	-	9.618	[110]
Ethanol	288.15	-	8.872	[111]
Ethanol	293.15	-	11.0	[110]
Ethanol	293.15	-	10.25	[111]
Ethanol	298.15	-	12.71	[110]
Ethanol	298.15	-	11.74	[111]
Ethanol	303.15	-	14.41	[110]
Ethanol	303.15	-	13.17	[111]
Ethanol	308.15	-	16.18	[110]
Ethanol	308.15	-	15.21	[111]
Ethanol	313.15	-	18.25	[110]
Ethanol	313.15	-	17.52	[111]
Ethanol	318.15	-	20.61	[110]
Ethanol	323.15	-	23.17	[110]
Ethanol	328.15	-	25.76	[110]
Ethyl acetate	273.15	-	18.11	[111]
Ethyl acetate	278.15	-	20.69	[111]
Ethyl acetate	283.15	-	23.93	[111]
Ethyl acetate	288.15	-	27.25	[111]
Ethyl acetate	293.15	-	31.04	[111]
Ethyl acetate	298.15	-	35.0	[111]
Ethyl acetate	303.15	-	39.91	[111]
Ethyl acetate	308.15	-	44.63	[111]
Ethyl acetate	313.15	-	49.78	[111]
Isopropanol	288.15	-	3.686	[110]
Isopropanol	293.15	-	4.247	[110]
Isopropanol	298.15	-	4.897	[110]
Isopropanol	303.15	-	5.634	[110]
Isopropanol	308.15	-	6.408	[110]
Isopropanol	313.15	-	7.29	[110]
Isopropanol	318.15	-	8.239	[110]
Isopropanol	323.15	-	9.246	[110]
Isopropanol	328.15	-	10.53	[110]
Methanol	273.15	-	5.56	[111]
Methanol	278.15	-	6.277	[111]
Methanol	283.15	-	7.054	[111]
Methanol	288.15	-	8.018	[111]
Methanol	293.15	-	8.942	[111]
Methanol	298.15	-	10.02	[111]
Methanol	303.15	-	11.27	[111]
Methanol	308.15	-	12.71	[111]
Methanol	313.15	-	14.17	[111]
Toluene	273.15	-	20.26	[111]
Toluene	278.15	-	23.9	[111]
Toluene	283.15	-	27.34	[111]
Toluene	288.15	-	31.7	[111]
Toluene	293.15	-	36.47	[111]
Toluene	298.15	-	41.91	[111]
Toluene	303.15	-	47.85	[111]
Toluene	308.15	-	54.87	[111]
Toluene	313.15	-	62.36	[111]
Water	288.15	-	0.045	[110]
Water	293.15	-	0.05846	[110]
Water	298.15	-	0.0752	[110]
Water	303.15	-	0.096	[110]
Water	308.15	-	0.1224	[110]
Water	313.15	-	0.1525	[110]
Water	318.15	-	0.191	[110]
Water	323.15	-	0.2349	[110]
Water	328.15	-	0.2934	[110]

Molecule 3D descriptors

Descriptor	Value
PMI1	1390.1370
PMI2	9223.1039
PMI3	9475.8224
NPR1	0.1467
NPR2	0.9733
RadiusOfGyration	5.0588
InertialShapeFactor	0.0007
Eccentricity	0.9892
Asphericity	0.6284
SpherocityIndex	0.2095
PBF	1.1242