Griseofulvin

CAS Number: 126-07-8

Molecular Mass: 352.8 g/mol

Formula: C₁₇H₁₇ClO₆

Smiles: COC1=CC(=O)C[C@@H](C)[C@]12Oc1c(Cl)c(OC)cc(OC)c1C2=O

Synonymes:

Griseofulvin, griseofulvin, 126-07-8, (+)-Griseofulvin, Fulvicin, Amudane, Fulcin, Griseofulvina, Griseofulvinum, Grifulvin, Grisactin, Grisovin, Spirofulvin, Lamoryl, Curling factor, Grisefuline, Griseofulvine, Grisofulvin, Grizeofulvin, Likuden, Grysio, Poncyl, Neo-Fulcin, Delmofulvina, Fulvicin-P/G, Fulvinil, Fulvistatin, Fungivin, Gresfeed, Grifulin, Griscofulvin, Guservin, Murfulvin, Fulcine, Fulvina, Greosin, Biogrisin-FP, Fulvican grisactin, Griseofulvin-forte, Fulvicin-U/F, Xuanjing, Grisactin V, GRISEOFULVIN, MICROCRYSTALLINE, Gricin, Griseo, Grifulvin V, USAF SC-2, Griseofulvin microsize, NSC 34533, GRISEOFULVIN, MICROSIZE, NSC-755822, 32HRV3E3D5, (2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H-spiro[1-benzofuran-2,1'-cyclohexan]-2'-ene-3,4'-dione, DTXSID8020674, Griseofulvin permeability diameter, NSC-34533, 7-Chloro-4,6,2'-trimethoxy-6'-methylgris-2'-en-3,4'-dione, DTXCID20674, (2S,5'R)-7-chloro-3',4,6-trimethoxy-5'-methylspiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione, Spiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'S-trans)-, CHEBI:27779, 7-Chloro-2',4,6-trimethoxy-6'beta-methylspiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione, (1'S,6'R)-7-Chloro-2',4,6-trimethoxy-6'-methylspiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione, Spiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl-, (2S-trans)-, FulvicinUF, GrisPEG, Fulvicin U F, Griseofulvin, (+)-, Gris PEG, Spiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'S,6'R)-, GRISEOFULVIN POWDER, Fulsovin, Grivate, Grisol af, (2S,5'R)-7-chloro-3',4,6-trimethoxy-5'-methylspiro(1-benzofuran-2,4'-cyclohex-2-ene)-1',3-dione, (2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H-spiro(1-benzofuran-2,1'-cyclohexan)-2'-ene-3,4'-dione, Grysio (Microsize), Fulvicin U/F Powder, Fulcin 125, Fulcin 500, Fulvicin U/F Tablets, RefChem:5870, Griseofulvin (microsize), Griseofulviin (microsize), Ultramicrosize Griseofulvin, Fulvicin U/F Bolus Veterinary, D01AA08, D01BA01, Ultramicrosize Griseofulvin Tablets, (1'S-trans)-7-Chloro-2',4,6-trimethoxy-6'-methylspiro(benzofuran-2(3H),1'-cyclohex-2'-ene)-3,4'-dione, 204-767-4, Griseofulvine [INN-French], Griseofulvinum [INN-Latin], Griseofulvina [INN-Spanish], Grisetin, MFCD00082343, GRISEOFULVIN, ULTRAMICROCRYSTALLINE, C17H17ClO6, Griseofulvin (Standard), Griseomix, Grisactin Ultra, Griseofulvin forte, Fulvicin P/G, NCGC00091120-01, (1'S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H-spiro[benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione, (1'S-trans)- 7-Chloro-2',4,6-trimethoxy-6'-methylspiro(benzofuran-2(3H),1'-cyclohex-2'-ene)-3,4'-dione, (2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione, ULTRAGRIS-165, ULTRAGRIS-330, Fulvicin Bolus, Fulvicin-U/F (Veterinary), Fulvicin Bolus (Veterinary), FULVICIN P/G 165, FULVICIN P/G 330, Caswell No. 471B, Fulvidex, (2S,5'R)-7-chloro-3',4,6-trimethoxy-5'-methyl-spiro[benzofuran-2,4'-cyclohex-2-ene]-1',3-dione, SMR000718755, CCRIS 320, HSDB 1722, SR-05000001535, 2884-22-2, EINECS 204-767-4, EPA Pesticide Chemical Code 471400, Griseofulvin and Alpha-IFN, BRN 0095226, UNII-32HRV3E3D5, Norofulvin, , AI3-51015, Grifulvin, , Grisactin, , Griseofulvin RS, Curling factor, , Fulvicin, , Grisovin, , Amudane, , fulvicin UF, Likuden, , Fulcin, , Gricin, , Griseofulvin [USP:INN:BAN:JAN], (+)-Epigriseofulvin, 7-Chloro-2',4,6-trimethoxy-6'alpha-methyl-spiro[benzofuran-2(3H)-1'-[2]cyclohexene]-3,4'-dione, (1'R,6'R)-7-Chloro-2',4,6-trimethoxy-6'-methyl-3H-spiro[benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione, Prestwick_247, Grisactin V (TN), Gris-peg (TN), IDIFULVIN, Griseofulvin,microsize, Spectrum_000816, CPD000718755, SpecPlus_000336, Prestwick3_000226, Spectrum2_000213, Spectrum3_000161, Spectrum4_000927, Spectrum5_000648, GRISEOFULVIN [MI], Griseofulvin [USP:INN], GRISEOFULVIN [INN], GRISEOFULVIN [JAN], CHEMBL562, GRISEOFULVIN [HSDB], GRISEOFULVIN [IARC], 7-Chloro-4,6-dimethoxycoumaran-3-one-2-spiro-1'-(2'-methoxy-6'-methylcyclohex-2'-en-4'-one), GRISEOFULVIN [VANDF], SCHEMBL21988, Amudane, Fulvicin, Grisactin, BSPBio_000271, BSPBio_001621, GRISEOFULVIN [MART.], KBioGR_001454, KBioSS_001296, SPECTRUM200046, (2S-trans)-7-Chloro-2',4,6-trimethoxy-6'-methylspiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione, 5-18-05-00150 (Beilstein Handbook Reference), MLS001304062, MLS002152905, MLS002154239, BIDD:GT0024, DivK1c_000154, DivK1c_006432, GRISEOFULVIN [USP-RS], GRISEOFULVIN [WHO-DD], GRISEOFULVIN [WHO-IP], Griseofulvin (JAN/USP/INN), SPBio_000225, BPBio1_000299, MEGxm0_000184, orb1308779, orb3012982, orb3025493, SCHEMBL29379397, ACon0_000953, ACon1_001843, BDBM31775, Fulvicin-U/F Powder and Tablets, Griseofulvin - Bio-X trade mark, HMS500H16, KBio1_000154, KBio1_001376, KBio2_001296, KBio2_003864, KBio2_006432, KBio3_001121, GRISEOFULVIN [GREEN BOOK], NINDS_000154, GLXC-04995, GRISEOFULVIN [ORANGE BOOK], HMS1923E09, HMS2091A03, HMS2095N13, HMS2235F13, HMS3259D05, HMS3712N13, Pharmakon1600-00200046, GRISEOFULVIN [EP MONOGRAPH], (2S)-trans-7-Chloro-2',4,6-trimethoxy-6'-methylspiro(benzofuran-2[3H],1'-[2]cyclohexene)-3,4'-dione, 7-CHLORO-2',4,6-TRIMETHOXY-6'.BETA.-METHYLSPIRO(BENZOFURAN-2(3H),1'-(2)CYCLOHEXENE)-3,4'-DIONE, MSK21132, GRISEOFULVIN [USP MONOGRAPH], Tox21_111087, Tox21_202235, Tox21_303005, CCG-38416, EBC-14149, HY-17583R, LMPK13060001, NSC755822, s4071, GRISEOFULVINUM [WHO-IP LATIN], AKOS015896380, Tox21_111087_1, CS-3426, DB00400, FG23704, NC00616, SDCCGMLS-0066450.P001, IDI1_000154, NCGC00091120-02, NCGC00091120-03, NCGC00091120-04, NCGC00091120-05, NCGC00091120-06, NCGC00091120-07, NCGC00091120-08, NCGC00091120-09, NCGC00091120-13, NCGC00256353-01, NCGC00259784-01, (2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H-spiro[benzofuran-2,1'-cyclohexan]-2'-ene-3,4'-dione, AS-13736, BT164513, HY-17583, SY071186, Griseofulvin 100 microg/mL in Acetonitrile, CS-0695022, G0384, NS00011725, EN300-52615, BIM-0051396.0001, C06686, D00209, AB00052005_07, Griseofulvin, VETRANAL(TM), analytical standard, F354301, GRISEOFULVIN PERMEABILITY DIAMETER [USP-RS], Q416096, SR-01000837512, doi:10.14272/DDUHZTYCFQRHIY-RBHXEPJQSA-N.1, SR-01000837512-2, SR-05000001535-1, SR-05000001535-3, SR-05000001535-4, BRD-K08273968-001-05-9, BRD-K08273968-001-09-1, BRD-K08273968-001-16-6, BRD-K08273968-001-19-0, Z756424454, Griseofulvin, British Pharmacopoeia (BP) Reference Standard, Griseofulvin, from Penicillium griseofulvum, 97.0-102.0%, Griseofulvin, European Pharmacopoeia (EP) Reference Standard, Griseofulvin, United States Pharmacopeia (USP) Reference Standard, Griseofulvin Permeability Diameter, United States Pharmacopeia (USP) Reference Standard, Griseofulvin, Pharmaceutical Secondary Standard, Certified Reference Material, (1'S,6'R)-7-Chloro-2',4,6-trimethoxy-6'-methyl-3H-spiro[[1]benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione, 107912-37-8, 7-Chloro-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1',- [2]cyclohexene]-3,4'-dione, Spiro[benzofuran-2(3H),1-cyclohex[2]ene]-3,4-dione, 7-chloro-2,4,6-trimethoxy-6-methyl-, (2S,6R)-

Bioactivity: -

Solubility in Different Solvents

Solvent	Temperature [K]	Crystal form	Solubility [mg/mL]	Reference
1,2-Dichloroethane	290.05	-	89.98	[123]
1,2-Dichloroethane	294.3	-	95.11	[123]
1,2-Dichloroethane	300.25	-	100.4	[123]
1,2-Dichloroethane	305.55	-	106.5	[123]
1,2-Dichloroethane	310.05	-	112.9	[123]
1,2-Dichloroethane	315.65	-	119.8	[123]
1,2-Dichloroethane	319.35	-	128.7	[123]
1,2-Dichloroethane	324.05	-	137.9	[123]
1,2-Dichloroethane	329.65	-	148.3	[123]
Acetone	281.95	-	31.83	[123]
Acetone	286.4	-	34.7	[123]
Acetone	291.85	-	37.62	[123]
Acetone	296.4	-	41.12	[123]
Acetone	300.8	-	45.11	[123]
Acetone	305.05	-	48.67	[123]
Acetone	310.25	-	55.43	[123]
Acetone	313.65	-	60.69	[123]
Acetone	317.05	-	67.24	[123]
Acetonitrile	278.15	-	22.82	[122]
Acetonitrile	283.15	-	25.27	[122]
Acetonitrile	288.15	-	28.43	[122]
Acetonitrile	293.15	-	31.97	[122]
Acetonitrile	298.15	-	35.97	[122]
Acetonitrile	303.15	-	40.78	[122]
Acetonitrile	308.15	-	46.21	[122]
Acetonitrile	313.15	-	52.4	[122]
Acetonitrile	318.15	-	58.86	[122]
Acetonitrile	323.15	-	66.44	[122]
Dimethyl sulfoxide	296.75	-	84.27	[123]
Dimethyl sulfoxide	301.15	-	93.24	[123]
Dimethyl sulfoxide	306.15	-	102.0	[123]
Dimethyl sulfoxide	310.85	-	108.8	[123]
Dimethyl sulfoxide	315.55	-	119.2	[123]
Dimethyl sulfoxide	320.55	-	129.3	[123]
Dimethyl sulfoxide	326.55	-	139.8	[123]
Dimethyl sulfoxide	331.95	-	149.2	[123]
Dimethyl sulfoxide	336.75	-	159.7	[123]
Dimethyl sulfoxide	341.05	-	169.8	[123]
Dimethyl sulfoxide	346.25	-	180.8	[123]
Dimethyl sulfoxide	351.7	-	192.5	[123]
Dimethyl sulfoxide	357.6	-	202.5	[123]
Dimethylacetamide	296.2	-	98.25	[123]
Dimethylacetamide	301.25	-	107.1	[123]
Dimethylacetamide	305.75	-	117.7	[123]
Dimethylacetamide	310.75	-	126.2	[123]
Dimethylacetamide	314.95	-	132.7	[123]
Dimethylacetamide	319.25	-	142.4	[123]
Dimethylacetamide	324.75	-	151.8	[123]
Dimethylacetamide	330.05	-	161.9	[123]
Dimethylacetamide	336.15	-	172.8	[123]
Dimethylacetamide	340.25	-	186.3	[123]
Dimethylacetamide	345.75	-	197.2	[123]
Dimethylacetamide	350.55	-	208.6	[123]
Dimethylacetamide	354.78	-	221.3	[123]
Dimethylformamide	278.15	-	22.62	[122]
Dimethylformamide	283.15	-	25.15	[122]
Dimethylformamide	288.15	-	28.26	[122]
Dimethylformamide	293.15	-	32.44	[122]
Dimethylformamide	298.15	-	37.28	[122]
Dimethylformamide	303.15	-	42.7	[122]
Dimethylformamide	308.15	-	48.45	[122]
Dimethylformamide	313.15	-	54.67	[122]
Dimethylformamide	318.15	-	61.35	[122]
Dimethylformamide	323.15	-	70.12	[122]
Ethanol	278.15	-	1.341	[122]
Ethanol	283.15	-	1.557	[122]
Ethanol	288.15	-	1.843	[122]
Ethanol	293.15	-	2.24	[122]
Ethanol	298.15	-	2.681	[122]
Ethanol	303.15	-	3.241	[122]
Ethanol	308.15	-	3.865	[122]
Ethanol	313.15	-	4.608	[122]
Ethanol	318.15	-	5.463	[122]
Ethanol	323.15	-	6.559	[122]
Methanol	278.15	-	2.185	[122]
Methanol	283.15	-	2.465	[122]
Methanol	288.15	-	2.908	[122]
Methanol	293.15	-	3.597	[122]
Methanol	298.15	-	4.48	[122]
Methanol	303.15	-	5.442	[122]
Methanol	308.15	-	6.593	[122]
Methanol	313.15	-	7.903	[122]
Methanol	318.15	-	9.398	[122]
Methanol	323.15	-	11.2	[122]
Methyl ethyl ketone	289.65	-	32.95	[123]
Methyl ethyl ketone	296.95	-	37.23	[123]
Methyl ethyl ketone	302.95	-	40.66	[123]
Methyl ethyl ketone	308.25	-	45.59	[123]
Methyl ethyl ketone	315.05	-	49.65	[123]
Methyl ethyl ketone	320.4	-	54.4	[123]
Methyl ethyl ketone	325.45	-	57.76	[123]
Methyl ethyl ketone	330.35	-	62.05	[123]
N-Methyl-2-pyrrolidone	278.15	-	124.5	[122]
N-Methyl-2-pyrrolidone	283.15	-	132.0	[122]
N-Methyl-2-pyrrolidone	288.15	-	141.6	[122]
N-Methyl-2-pyrrolidone	293.15	-	151.0	[122]
N-Methyl-2-pyrrolidone	295.55	-	161.1	[123]
N-Methyl-2-pyrrolidone	298.15	-	162.3	[122]
N-Methyl-2-pyrrolidone	300.65	-	172.5	[123]
N-Methyl-2-pyrrolidone	303.15	-	171.8	[122]
N-Methyl-2-pyrrolidone	305.75	-	183.2	[123]
N-Methyl-2-pyrrolidone	308.15	-	182.5	[122]
N-Methyl-2-pyrrolidone	310.0	-	195.2	[123]
N-Methyl-2-pyrrolidone	313.15	-	194.7	[122]
N-Methyl-2-pyrrolidone	315.1	-	206.1	[123]
N-Methyl-2-pyrrolidone	318.15	-	205.9	[122]
N-Methyl-2-pyrrolidone	320.6	-	216.7	[123]
N-Methyl-2-pyrrolidone	323.15	-	217.8	[122]
N-Methyl-2-pyrrolidone	325.45	-	228.5	[123]
N-Methyl-2-pyrrolidone	330.45	-	239.7	[123]
N-Methyl-2-pyrrolidone	335.55	-	252.7	[123]
N-Methyl-2-pyrrolidone	340.35	-	267.0	[123]
N-Methyl-2-pyrrolidone	345.55	-	287.9	[123]
N-Methyl-2-pyrrolidone	350.35	-	302.0	[123]
N-Methyl-2-pyrrolidone	355.65	-	314.8	[123]
Water	278.15	-	0.0038	[122]
Water	283.15	-	0.00489	[122]
Water	288.15	-	0.006	[122]
Water	293.15	-	0.0076	[122]
Water	298.15	-	0.0092	[122]
Water	303.15	-	0.0111	[122]
Water	308.15	-	0.014	[122]
Water	313.15	-	0.0173	[122]
Water	318.15	-	0.0214	[122]
Water	323.15	-	0.0263	[122]

Molecule 3D descriptors

Descriptor	Value
PMI1	1381.1885
PMI2	3247.4682
PMI3	3836.7913
NPR1	0.3600
NPR2	0.8464
RadiusOfGyration	3.4639
InertialShapeFactor	0.0006
Eccentricity	0.9330
Asphericity	0.2752
SpherocityIndex	0.3780
PBF	1.1820