Pazopanib

Molecular Mass: 437.5 g/mol

Formula: C₂₁H₂₃N₇O₂S

Smiles: Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O

Synonymes:

Pazopanib, 444731-52-6, GW786034, 5-((4-((2,3-dimethyl-2H-indazol-6-yl)(methyl)amino)pyrimidin-2-yl)amino)-2-methylbenzenesulfonamide, pazopanibum, 7RN5DR86CK, NSC-752782, DTXSID8048733, GW780604, GW-780604, 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide, DTXCID1028659, CHEBI:71219, Benzenesulfonamide, 5-((4-((2,3-dimethyl-2H-indazol-6-yl)methylamino)-2-pyrimidinyl)amino)-2-methyl-, 5-({4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide, RefChem:55812, Votrient, 790713-33-6, GW-786034, MFCD11616589, 5-[4-[(2,3-Dimethyl-2H-indazol-6-yl)-methyl-amino]-pyrimidin-2-ylamino]-2-methyl-benzenesulfonamide, 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide, GW 78603, GW 786034, C21H23N7O2S, 5-(4-((2,3-dimethyl-2H-indazol-6-yl)(methyl)amino)pyrimidin-2-ylamino)-2-methylbenzenesulfonamide, NCGC00188865-01, 5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide, Pazopanib [INN], 5-[[4-[(2,3-dimethyl-2h-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide, CAS-444731-52-6, Pazopanib [INN:BAN], UNII-7RN5DR86CK, Pazopanib?, HSDB 8210, Benzenesulfonamide, 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-, 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide, 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide, GW 786034, Pazopanib, Votrient, Pazopanib (Standard), GW 786034B, indazolylpyrimidine 13, Pazopanib (free base), Kinome_3790, PAZOPANIB [MI], PAZOPANIB [VANDF], PAZOPANIB [WHO-DD], PAZOPANIB [EMA EPAR], 5-[[4-[(2,3-dimethylindazol-6-yl)-methyl-amino]pyrimidin-2-yl]amino]-2-methyl-benzenesulfonamide, SCHEMBL588608, Pazopanib - Bio-X trade mark, CHEMBL477772, GTPL5698, JMC514632 Compound 13, orb1310940, SCHEMBL29392503, BDBM26474, cid_10113978, CUIHSIWYWATEQL-UHFFFAOYSA-N, GLXC-90392, HMS3244C21, HMS3244C22, HMS3244D21, HMS3656L14, HMS3745G05, HMS5081I04, EX-A1241, Tox21_113174, EBC-12617, HY-10208R, NSC752782, NSC800839, s3012, T0097L, AKOS005145819, Tox21_113174_1, AC-8522, CCG-265010, CS-0269, DB06589, FD26771, NSC 752782, NSC-800839, SB17290, SDCCGSBI-0647656.P002, NCGC00188865-02, NCGC00188865-03, NCGC00188865-10, AS-11066, BD164238, BP-44038, HY-10208, SY067128, NS00070516, SW218082-3, EN300-57325, P-6706, SBI-0647656.0001, AB01273967-01, AB01273967-02, AB01273967_05, AB01273967_06, AR-270/43507999, Pazopanib [INN], UNII-7RN5DR86CK, Pazopanib, , Q7157043, BRD-K74514084-001-03-9, BRD-K74514084-003-02-7, BRD-K74514084-003-09-2, Z1541638525, 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]-2-pyrimidinyl}amino)-2-methylbenzenesulfonamide, 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]-pyrimidin-2-yl]amino]-2-methyl-benzenesulfonamide

Bioactivity: -

Solubility in Different Solvents

Solvent	Temperature [K]	Crystal form	Solubility [mg/mL]	Reference
1-Butanol	288.15	-	0.0512	[134]
1-Butanol	293.15	-	0.06977	[134]
1-Butanol	298.15	-	0.0892	[134]
1-Butanol	303.15	-	0.1107	[134]
1-Butanol	308.15	-	0.1347	[134]
1-Butanol	313.15	-	0.1601	[134]
1-Butanol	318.15	-	0.1886	[134]
1-Butanol	323.15	-	0.2181	[134]
1-Butanol	328.15	-	0.2511	[134]
1-Propanol	288.15	-	0.05855	[134]
1-Propanol	293.15	-	0.0776	[134]
1-Propanol	298.15	-	0.0971	[134]
1-Propanol	303.15	-	0.121	[134]
1-Propanol	308.15	-	0.1469	[134]
1-Propanol	313.15	-	0.1776	[134]
1-Propanol	318.15	-	0.208	[134]
1-Propanol	323.15	-	0.2487	[134]
1-Propanol	328.15	-	0.2883	[134]
Acetonitrile	288.15	-	0.0091	[134]
Acetonitrile	293.15	-	0.0256	[134]
Acetonitrile	298.15	-	0.04272	[134]
Acetonitrile	303.15	-	0.0646	[134]
Acetonitrile	308.15	-	0.0907	[134]
Acetonitrile	313.15	-	0.1168	[134]
Acetonitrile	318.15	-	0.1447	[134]
Acetonitrile	323.15	-	0.1767	[134]
Acetonitrile	328.15	-	0.2158	[134]
Ethanol	288.15	-	0.06	[133]
Ethanol	293.15	-	0.076	[133]
Ethanol	298.15	-	0.0947	[133]
Ethanol	303.15	-	0.1192	[133]
Ethanol	308.15	-	0.1442	[133]
Ethanol	313.15	-	0.1734	[133]
Ethanol	318.15	-	0.2079	[133]
Ethanol	323.15	-	0.2469	[133]
Ethanol	328.15	-	0.2909	[133]
Ethyl acetate	288.15	-	0.0278	[133]
Ethyl acetate	293.15	-	0.0361	[133]
Ethyl acetate	298.15	-	0.0461	[133]
Ethyl acetate	303.15	-	0.0578	[133]
Ethyl acetate	308.15	-	0.0715	[133]
Ethyl acetate	313.15	-	0.0871	[133]
Ethyl acetate	318.15	-	0.107	[133]
Ethyl acetate	323.15	-	0.131	[133]
Ethyl acetate	328.15	-	0.1573	[133]
Isopropanol	288.15	-	0.0542	[133]
Isopropanol	293.15	-	0.0681	[133]
Isopropanol	298.15	-	0.0849	[133]
Isopropanol	303.15	-	0.1051	[133]
Isopropanol	308.15	-	0.1266	[133]
Isopropanol	313.15	-	0.1513	[133]
Isopropanol	318.15	-	0.1808	[133]
Isopropanol	323.15	-	0.2155	[133]
Isopropanol	328.15	-	0.2576	[133]

Molecule 3D descriptors

Descriptor	Value
PMI1	1039.9045
PMI2	14305.1205
PMI3	14643.7651
NPR1	0.0710
NPR2	0.9769
RadiusOfGyration	5.8541
InertialShapeFactor	0.0009
Eccentricity	0.9975
Asphericity	0.8031
SpherocityIndex	0.1155
PBF	0.9730