Sofosbuvir
CAS Number: 1190307-88-0
Molecular Mass: 529.45 g/mol
Formula: C22H29FN3O9P
Smiles: O=C(OC(C)C)C(NP(=O)(OC=1C=CC=CC1)OCC2OC(N3C=CC(=O)NC3=O)C(F)(C)C2O)C
Synonymes: Sofosbuvir, L-Alanine, N-[[P(S),2′R]-2′-deoxy-2′-fluoro-2′-methyl-P-phenyl-5′-uridylyl]-, 1-methylethyl ester, PSI 7977, Sofosbuvir, GS 7977, Sovaldi, Hepcinat, Resof, Hepcvir, Sovihep, Isopropyl (2S)-2-[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-yl]methoxy-phenoxy-phosphoryl]amino]propionate, Sofos 400
Bioactivity: -
Solubility in Different Solvents
| Solvent | Temperature [K] | Crystal form | Solubility [mg/mL] | Reference |
|---|---|---|---|---|
| Cyclohexane | 298.0 | Form VIII | 0.00014 | None |
| Acetonitrile | 298.0 | Form VIII | 258.7? | None |
Thermodynamic parameters of solution
| Solvent | Temperature [K] | Crystal form | ΔHsol [kJ/mol] | ΔSsol [J/mol/K] | ΔGsol [kJ/mol] | Reference |
|---|---|---|---|---|---|---|
| Cyclohexane | 298.0 | Form VIII | - | - | 37.5 | - |
| Acetonitrile | 298.0 | Form VIII | - | - | 1.77 | - |