Glyburide

CAS Number: 10238-21-8

Molecular Mass: 494.0 g/mol

Formula: C₂₃H₂₈ClN₃O₅S

Smiles: COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1

Synonymes:

Glyburide, Glibenclamide, glyburide, 10238-21-8, Glynase, Euglucon, Semi-daonil, Libanil, Glibenclamida, Glibenclamidum, Calabren, Lederglib, HB 419, Glyburide (micronized), 1-(p-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea, SX6K58TVWC, 5-Chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide, NSC-759618, 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide, U-26,452, 5-chloro-N-[2-(4-{[(cyclohexylcarbamoyl)amino]sulfonyl}phenyl)ethyl]-2-methoxybenzamide, U-26452, CHEBI:5441, U-26,45, N-(4-(beta-(2-Methoxy-5-chlorbenzamido)-aethyl)-benzolsulfonyl)-N'-cyclohexyl-harnstoff, HB419, 5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide, HB420, HB 420, Gliken, Glynase Prestab, Diabetamide 5, 5-chloro-N-(2-(4-(((cyclohexylcarbamoyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide, 5-chloro-N-(2-(4-(cyclohexylcarbamoylsulfamoyl)phenyl)ethyl)-2-methoxybenzamide, Diabetamide 2.5, RefChem:5865, A10BB01, 4-(2-(5-Chloro-2-methoxybenzoylamino)ethyl)-N-(cyclohexylcarbamoyl)benzenesulfonamide, 233-570-6, Glybenclamide, Diabeta, Micronase, Daonil, Maninil, Glybenzcyclamide, Apo-Glibenclamide, Euglucon 5, Azuglucon, Bastiverit, Benclamin, Betanase, Duraglucon, Euglucan, Euglykon, Glibenil, Glucolon, Orabetic, Prodiabet, Renabetic, Yuglucon, Dibelet, Gilemal, Glibens, Glibil, Glimel, Glimide, Humedia, Suraben, Tiabet, Adiab, Melix, Pira, Med-Glionil, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide, Glibenclamidum [INN-Latin], C23H28ClN3O5S, Glibenclamida [INN-Spanish], glyburide (glibenclamide), HB-419, MFCD00056625, UR 606, 5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]-amino]sulfonyl]phenyl]-ethyl]-2-methoxybenzamide, Cirara, 1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea, Neogluconin, Glibenclamide [INN], U 26452, DTXSID0037237, Gewaglucon, Glibenbeta, Glidiabet, Glucobene, Glucohexal, Glucoremed, Hexaglucon, Lisaglucon, Normoglucon, Praeciglucon, Cytagon, Euclamin, Glamide, Glibesyn, Glibetic, Gliboral, Glisulin, Glitisol, Glubate, Glucomid, Glucoven, Glycomin, Miglucan, Debtan, Gliban, Gliben, Glibet, Glicem, Gluben, Glyben, Nadib, Sugril, CHEMBL472, Novo-Glyburide, Glibenclamid AL, Gen-Glybe, Norglicem 5, Betanese 5, N-(4-(2-(5-Chloro-2-methoxybenzamido)ethyl)phenylsulfonyl)-N'-cyclohexylurea, Glibenclamid Fabra, Benzamide, 5-chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxy-, MLS000069721, Glibenclamid Basics, Glibenclamid-Cophar, Glibenclamid Heumann, Semi-Euglucon, Glibenclamid Genericon, 5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide, Hemi-Daonil, Glibenclamid-Ratiopharm, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, Urea, 1-(p-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexyl-, Benzamide, 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy-, Glyburide [USAN], NCGC00015467-11, Abbenclamide, Diabiphage, Glibadone, SMR000058229, Semi-Gliben-Puren N, GBN 5, CAS-10238-21-8, Glibenclamid Riker M., S1716, Urea, 1-((p-(2-(chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexyl-, Micronized glyburide, DTXCID8017237, Glycron, 1-[[p-[2-(5-Chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-cyclohexylurea, 5-chloro-N-(2-{4-[N-(N-cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)-phenethyl)-2-methoxybenzamide, Glyburide (USP), Micronase (TN), 1-{4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonyl}-3-cyclohexylurea, 1-{4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonyl}-3-cyclohexylurea, Diabeta (TN), Glynase (TN), SR-01000000196, Glyburide [USAN:USP], EINECS 233-570-6, UNII-SX6K58TVWC, BRN 2230085, Glibenclamid, Amglidia, Delmide, Diabetamide, , Glyburide, , Micronase, , Calabren, , Euglucon, , Gilemal, , Glynase, , Libanil, , Daonil, , DiaBeta, , Malix, , 5-chloro-N-(4-[N-(cyclohexylcarbamoyl)sulfamoyl]phenethyl)-2-methoxybenzamide, Glibenclamide CRS, GBM, Prestwick_569, RP-1127, Spectrum_000250, Tocris-0911, Glybenzcyclamide, 99%, Glibenclamide, Glyburide, Glyburide, Glibenclamide, Opera_ID_801, GLYBURIDE [MI], Glibenclamide (Standard), Prestwick0_000316, Prestwick1_000316, Prestwick2_000316, Prestwick3_000316, Spectrum2_001816, Spectrum3_001327, Spectrum4_001199, Spectrum5_001631, GLYBURIDE [VANDF], Lopac-G-0639, Probes1_000431, Probes2_000378, UPCMLD-DP006, G 0639, GLIBENCLAMIDE [JAN], GLYBURIDE [USP-RS], GLYBURIDE [WHO-IP], Glibenclamide (JP18/INN), CBiol_001790, Lopac0_000499, Oprea1_764617, SCHEMBL22009, BSPBio_000312, BSPBio_001351, BSPBio_003053, KBioGR_000071, KBioGR_001897, KBioSS_000071, KBioSS_000730, MLS001077262, BIDD:GT0239, DivK1c_000481, GLIBENCLAMIDE [MART.], SPECTRUM2300229, SPBio_001831, SPBio_002531, GLIBENCLAMIDE [WHO-DD], GLIBENCLAMIDE [WHO-IP], BPBio1_000344, GTPL2414, orb1307954, orb3025499, GLYBURIDE [ORANGE BOOK], SCHEMBL29355447, UPCMLD-DP006:001, HMS501I03, KBio1_000481, KBio2_000071, KBio2_000730, KBio2_002639, KBio2_003298, KBio2_005207, KBio2_005866, KBio3_000141, KBio3_000142, KBio3_002273, GLYBURIDE [USP MONOGRAPH], MSK7191, Glibenclamide - Bio-X trade mark, Glybenclamide, >=99% (HPLC), NINDS_000481, Bio1_000076, Bio1_000565, Bio1_001054, Bio2_000071, Bio2_000551, GLXC-05423, HMS1361D13, HMS1568P14, HMS1791D13, HMS1922L08, HMS1989D13, HMS2089L06, HMS2093P04, HMS2095P14, HMS3259O12, HMS3261D19, HMS3267A15, HMS3402D13, HMS3411F16, HMS3428D15, HMS3651E17, HMS3675F16, HMS3712P14, HMS5079L16, HMS6018I15, Pharmakon1600-02300229, PXB98502, GLIBENCLAMIDE [EP MONOGRAPH], Tox21_110158, Tox21_300758, Tox21_500499, BDBM50012957, CCG-39618, EBC-08611, GLUCOVANCE COMPONENT GLYBURIDE, HD 419, HY-15206R, MSK7191-100M, NSC759618, NSC813214, SBB057426, STK362992, GLIBENCLAMIDUM [WHO-IP LATIN], AKOS001487495, MSK7191-1000M, N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N'-cyclohexylurea, Tox21_110158_1, DB01016, FC23675, KS-5326, LP00499, NC00566, NSC 759618, NSC-813214, SB17414, SDCCGSBI-0050483.P004, 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxy-benzamide, IDI1_000481, IDI1_033821, Glibenclamide 1.0 mg/ml in Acetonitrile, NCGC00015467-01, NCGC00015467-02, NCGC00015467-03, NCGC00015467-04, NCGC00015467-05, NCGC00015467-06, NCGC00015467-07, NCGC00015467-08, NCGC00015467-09, NCGC00015467-10, NCGC00015467-12, NCGC00015467-13, NCGC00015467-14, NCGC00015467-15, NCGC00015467-16, NCGC00015467-17, NCGC00015467-18, NCGC00015467-20, NCGC00015467-21, NCGC00015467-36, NCGC00015467-37, NCGC00016689-01, NCGC00023447-02, NCGC00023447-04, NCGC00023447-05, NCGC00023447-06, NCGC00023447-07, NCGC00023447-08, NCGC00023447-09, NCGC00023447-10, NCGC00023447-11, NCGC00023447-12, NCGC00254662-01, NCGC00261184-01, BG166164, Glibenclamide for peak identification CRS, HY-15206, ST024780, SY057080, SBI-0050483.P003, Glyburide, meets USP testing specifications, AB00051949, EU-0100499, G0382, NS00001144, SW195828-5, Glibenclamide Solution in Methanol, 100ug/mL, C07022, D00336, D81733, EN300-117270, Glibenclamide Solution in Methanol, 1000ug/mL, M01823, AB00051949-16, AB00051949-17, AB00051949_18, AB00051949_19, Q420626, SR-01000000196-2, SR-01000000196-4, SR-01000000196-5, SR-01000000196-6, SR-01000000196-8, BRD-K36927236-001-06-0, BRD-K36927236-001-17-7, BRD-K36927236-001-30-0, BRD-K36927236-001-31-8, BRD-K36927236-001-32-6, Z277540138, Glybenclamide, European Pharmacopoeia (EP) Reference Standard, Glyburide, United States Pharmacopeia (USP) Reference Standard, 1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexyl urea, 5-Chloro-N-[4-(3-cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide, Glibenclamide for peak identification, European Pharmacopoeia (EP) Reference Standard, Glyburide (Glibenclamide), Pharmaceutical Secondary Standard, Certified Reference Material, N-(4-(.beta.-(2-Methoxy-5-chlorbenzamido)-aethyl)-benzolsulfonyl)-N'-cyclohexyl-harnstoff, N1-[4-({[(cyclohexylamino)carbonyl]amino}sulfonyl)phenethyl]-5-chloro-2-methoxybenzamide, (5-chloro-2-methoxyphenyl)-N-[2-(4-{[(cyclohexylamino)carbonylamino]sulfonyl}p henyl)ethyl]carboxamide, 5-Chloro-N-(2-[4-(([(cyclohexylamino)carbonyl]amino)sulfonyl)phenyl]ethyl)-2-methoxybenzamide #, 5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]-sulfonyl]phenyl]ethyl]-2-methoxy-benzamide, N-[(4-{2-[(5-chloro-2-methoxyphenyl)carbonylamino]ethyl}phenyl)sulfonyl](cyclo hexylamino)carboxamide

Bioactivity: -

Solubility in Different Solvents

Solvent	Temperature [K]	Crystal form	Solubility [mg/mL]	Reference
1-Butanol	283.15	-	1.016	[160]
1-Butanol	288.15	-	1.21	[160]
1-Butanol	293.15	-	1.304	[160]
1-Butanol	298.15	-	1.528	[160]
1-Butanol	303.15	-	1.784	[160]
1-Butanol	308.15	-	2.371	[160]
1-Butanol	313.15	-	3.425	[160]
1-Butanol	318.15	-	4.863	[160]
1-Butanol	323.15	-	7.106	[160]
1-Propanol	283.15	-	0.6699	[160]
1-Propanol	288.15	-	1.032	[161]
1-Propanol	288.15	-	0.8304	[160]
1-Propanol	293.15	-	1.274	[161]
1-Propanol	293.15	-	1.075	[160]
1-Propanol	298.15	-	1.557	[161]
1-Propanol	298.15	-	1.482	[160]
1-Propanol	303.15	-	1.978	[161]
1-Propanol	303.15	-	1.874	[160]
1-Propanol	308.15	-	2.788	[161]
1-Propanol	308.15	-	2.482	[160]
1-Propanol	313.15	-	3.703	[161]
1-Propanol	313.15	-	3.481	[160]
1-Propanol	318.15	-	4.84	[161]
1-Propanol	318.15	-	4.701	[160]
1-Propanol	323.15	-	6.218	[161]
1-Propanol	323.15	-	6.305	[160]
2-Butanol	283.15	-	0.3449	[160]
2-Butanol	288.15	-	0.4305	[160]
2-Butanol	293.15	-	0.5583	[160]
2-Butanol	298.15	-	0.755	[160]
2-Butanol	303.15	-	0.9806	[160]
2-Butanol	308.15	-	1.312	[160]
2-Butanol	313.15	-	1.92	[160]
2-Butanol	318.15	-	2.973	[160]
2-Butanol	323.15	-	4.616	[160]
Acetone	283.15	-	3.025	[159]
Acetone	283.15	-	3.216	[160]
Acetone	288.15	-	3.789	[159]
Acetone	288.15	-	3.848	[160]
Acetone	293.15	-	4.712	[159]
Acetone	293.15	-	4.642	[160]
Acetone	298.15	-	5.883	[159]
Acetone	298.15	-	5.973	[160]
Acetone	303.15	-	7.449	[159]
Acetone	303.15	-	7.222	[160]
Acetone	308.15	-	9.21	[159]
Acetone	308.15	-	8.797	[160]
Acetone	313.15	-	11.46	[159]
Acetone	313.15	-	11.19	[160]
Acetone	318.15	-	14.22	[159]
Acetone	318.15	-	13.89	[160]
Acetone	323.15	-	17.33	[159]
Acetone	323.15	-	16.81	[160]
Acetonitrile	283.15	-	0.5014	[160]
Acetonitrile	288.15	-	0.759	[161]
Acetonitrile	288.15	-	0.6781	[160]
Acetonitrile	293.15	-	0.9932	[161]
Acetonitrile	293.15	-	0.9277	[160]
Acetonitrile	298.15	-	1.349	[161]
Acetonitrile	298.15	-	1.225	[160]
Acetonitrile	303.15	-	1.706	[161]
Acetonitrile	303.15	-	1.513	[160]
Acetonitrile	308.15	-	2.131	[161]
Acetonitrile	308.15	-	2.073	[160]
Acetonitrile	313.15	-	2.747	[161]
Acetonitrile	313.15	-	2.896	[160]
Acetonitrile	318.15	-	3.906	[161]
Acetonitrile	318.15	-	3.799	[160]
Acetonitrile	323.15	-	5.151	[161]
Acetonitrile	323.15	-	5.037	[160]
Ethanol	283.15	-	0.8844	[159]
Ethanol	283.15	-	0.925	[160]
Ethanol	288.15	-	1.233	[159]
Ethanol	288.15	-	1.279	[160]
Ethanol	293.15	-	1.661	[159]
Ethanol	293.15	-	1.591	[160]
Ethanol	298.15	-	2.179	[159]
Ethanol	298.15	-	2.1	[160]
Ethanol	303.15	-	2.792	[159]
Ethanol	303.15	-	2.649	[160]
Ethanol	308.15	-	3.642	[159]
Ethanol	308.15	-	3.434	[160]
Ethanol	313.15	-	5.141	[159]
Ethanol	313.15	-	4.893	[160]
Ethanol	318.15	-	7.359	[159]
Ethanol	318.15	-	7.123	[160]
Ethanol	323.15	-	9.98	[159]
Ethanol	323.15	-	9.531	[160]
Ethyl acetate	283.15	-	0.4415	[159]
Ethyl acetate	283.15	-	0.461	[160]
Ethyl acetate	288.15	-	0.582	[159]
Ethyl acetate	288.15	-	0.6125	[160]
Ethyl acetate	293.15	-	0.7372	[159]
Ethyl acetate	293.15	-	0.7585	[160]
Ethyl acetate	298.15	-	0.934	[159]
Ethyl acetate	298.15	-	0.9054	[160]
Ethyl acetate	303.15	-	1.178	[159]
Ethyl acetate	303.15	-	1.127	[160]
Ethyl acetate	308.15	-	1.518	[159]
Ethyl acetate	308.15	-	1.434	[160]
Ethyl acetate	313.15	-	1.934	[159]
Ethyl acetate	313.15	-	1.844	[160]
Ethyl acetate	318.15	-	2.494	[159]
Ethyl acetate	318.15	-	2.369	[160]
Ethyl acetate	323.15	-	3.134	[159]
Ethyl acetate	323.15	-	3.037	[160]
Isopropanol	283.15	-	0.5199	[159]
Isopropanol	283.15	-	0.4933	[160]
Isopropanol	288.15	-	0.691	[161]
Isopropanol	288.15	-	0.6479	[159]
Isopropanol	288.15	-	0.5776	[160]
Isopropanol	293.15	-	0.7847	[161]
Isopropanol	293.15	-	0.8409	[159]
Isopropanol	293.15	-	0.8116	[160]
Isopropanol	298.15	-	1.081	[161]
Isopropanol	298.15	-	1.13	[159]
Isopropanol	298.15	-	1.04	[160]
Isopropanol	303.15	-	1.473	[161]
Isopropanol	303.15	-	1.377	[159]
Isopropanol	303.15	-	1.322	[160]
Isopropanol	308.15	-	1.965	[161]
Isopropanol	308.15	-	1.82	[159]
Isopropanol	308.15	-	1.721	[160]
Isopropanol	313.15	-	2.55	[161]
Isopropanol	313.15	-	2.665	[159]
Isopropanol	313.15	-	2.53	[160]
Isopropanol	318.15	-	3.623	[161]
Isopropanol	318.15	-	3.815	[159]
Isopropanol	318.15	-	3.89	[160]
Isopropanol	323.15	-	5.389	[161]
Isopropanol	323.15	-	5.572	[159]
Isopropanol	323.15	-	5.837	[160]
Methanol	283.15	-	1.596	[159]
Methanol	283.15	-	1.528	[160]
Methanol	288.15	-	2.216	[161]
Methanol	288.15	-	2.116	[159]
Methanol	288.15	-	2.021	[160]
Methanol	293.15	-	2.79	[161]
Methanol	293.15	-	2.679	[159]
Methanol	293.15	-	2.56	[160]
Methanol	298.15	-	3.511	[161]
Methanol	298.15	-	3.643	[159]
Methanol	298.15	-	3.441	[160]
Methanol	303.15	-	4.406	[161]
Methanol	303.15	-	4.551	[159]
Methanol	303.15	-	4.281	[160]
Methanol	308.15	-	5.408	[161]
Methanol	308.15	-	5.716	[159]
Methanol	308.15	-	5.848	[160]
Methanol	313.15	-	7.31	[161]
Methanol	313.15	-	7.865	[159]
Methanol	313.15	-	8.285	[160]
Methanol	318.15	-	11.14	[161]
Methanol	318.15	-	12.16	[159]
Methanol	318.15	-	12.43	[160]
Methanol	323.15	-	15.4	[161]
Methanol	323.15	-	16.12	[159]
Methanol	323.15	-	16.86	[160]
Methyl acetate	283.15	-	0.8001	[160]
Methyl acetate	288.15	-	1.027	[160]
Methyl acetate	293.15	-	1.256	[160]
Methyl acetate	298.15	-	1.525	[160]
Methyl acetate	303.15	-	1.819	[160]
Methyl acetate	308.15	-	2.27	[160]
Methyl acetate	313.15	-	2.981	[160]
Methyl acetate	318.15	-	3.777	[160]
Methyl acetate	323.15	-	4.589	[160]
Methyl isobutyl ketone	283.15	-	0.7915	[160]
Methyl isobutyl ketone	288.15	-	0.9033	[160]
Methyl isobutyl ketone	293.15	-	1.091	[160]
Methyl isobutyl ketone	298.15	-	1.321	[160]
Methyl isobutyl ketone	303.15	-	1.664	[160]
Methyl isobutyl ketone	308.15	-	2.052	[160]
Methyl isobutyl ketone	313.15	-	2.528	[160]
Methyl isobutyl ketone	318.15	-	3.03	[160]
Methyl isobutyl ketone	323.15	-	3.467	[160]
Water	283.15	-	0.0023	[159]
Water	288.15	-	0.0025	[161]
Water	288.15	-	0.0024	[159]
Water	293.15	-	0.0028	[161]
Water	293.15	-	0.0029	[159]
Water	298.15	-	0.0034	[161]
Water	298.15	-	0.0035	[159]
Water	303.15	-	0.0043	[161]
Water	303.15	-	0.0045	[159]
Water	308.15	-	0.0059	[161]
Water	308.15	-	0.0063	[159]
Water	313.15	-	0.0083	[161]
Water	313.15	-	0.0088	[159]
Water	318.15	-	0.0118	[161]
Water	318.15	-	0.0123	[159]
Water	323.15	-	0.0208	[161]
Water	323.15	-	0.0212	[159]

Molecule 3D descriptors

Descriptor	Value
PMI1	3022.0165
PMI2	15616.7721
PMI3	17852.6630
NPR1	0.1693
NPR2	0.8748
RadiusOfGyration	6.0773
InertialShapeFactor	0.0003
Eccentricity	0.9856
Asphericity	0.5761
SpherocityIndex	0.0904
PBF	0.8856