(S)-Naproxen

CAS Number: 22204-53-1

Molecular Mass: 230.26 g/mol

Formula: C₁₄H₁₄O₃

Smiles: COc1ccc2cc([C@H](C)C(=O)O)ccc2c1

Synonymes:

(S)-Naproxen, NAPROXEN, 22204-53-1, Naprosyn, (+)-Naproxen, Equiproxen, Naproxene, (S)-(+)-Naproxen, Naixan, d-Naproxen, Ec-Naprosyn, (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid, Laraflex, Naprosyne, Naproxeno, Nycopren, Calosen, Reuxen, Bonyl, Naxen, Axer, (+)-(S)-Naproxen, (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid, Naproxenum, Naprius, Veradol, Xenar, Dysmenalgit N, RS-3540, Napren E, (S)-2-(6-Methoxy-2-naphthyl)propionic acid, (+)-2-(6-Methoxy-2-naphthyl)propionic acid, (+)-2-(Methoxy-2-naphthyl)-propionic acid, (S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid, d-2-(6-Methoxy-2-naphthyl)propionic acid, (S)-2-(6-Methoxy-2-naphthyl)propanoic acid, CG 3117, (+)-2-(Methoxy-2-naphthyl)-propionsaeure, (+)-(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid, NSC-750183, NSC-757239, 57Y76R9ATQ, CHEBI:7476, DTXSID4040686, (+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid, 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, (+)-, DTXCID2020686, PN400 COMPONENT NAPROXEN, Apranax, Numidan, 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, (S)-, Methoxypropiocin, Stirlescent, Condrotec, Grenoxal, Kenosyn, Naprotin, Prosaid, Rimoxyn, Timpron, Naproxen oral, Napratec op, Feminax Ultra, Pranoxen continus, Naprosyn EC, Equiproxen Granules, Arthrosin 250, Arthrosin 500, Naproxen, Capsaicin, Naprosyn 375, Rheuflex 250, Rheuflex 500, Trepoxen-250, Arthrosin 250 ec, Arthrosin 500 ec, Timpron 250 ec, Timpron 500 ec, VALROX, EC-NAPROXEN, 6-methoxy-alpha-methyl-2-naphthaleneacetic acid, RefChem:6469, Naproxen Delayed Release, Naproxen Oral Suspension, NAPROXEN,HISTIDINE, Equiproxen 10% Solution, G02CC02, M01AE02, M02AA12, Sallus Pain Relief Collection With Naproxen, 244-838-7, (2S)-2-(6-methoxynaphthalen-2-yl)propanoate, (S)-2-(6-methoxynaphthalen-2-yl)propanoic acid, Aleve, naproxen(+), Acusprain, Anexopen, Arthrisil, Artrixen, Artroxen, Bipronyl, Clinosyn, Danaprox, Flexipen, Floginax, Leniartil, Novonaprox, Apronax, Artagen, Atiflan, Congex, Daprox, Genoxen, Lefaine, Nafasol, Nalyxan, Napflam, Napmel, Naposin, Napren, Fuxen, Naxyn, Apo-Naproxen, Anaprox, Dysmenalgit, (2S)-2-(6-methoxy-2-naphthyl)propanoic acid, Apo-Napro-NA, (alphas)-6-methoxy-alpha-methyl-2-naphthaleneacetic acid, MFCD00010500, Proxen, (S)-(+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid, CHEMBL154, d-2-(6'-Methoxy-2'-naphthyl)-propionsaeure, Propionic acid, 2-(6-methoxy-2-naphthyl)-, (+)-, Duk, 2-Naphthaleneacetic acid, 6-methoxy-.alpha.-methyl-, (S)-, Headlon, Napratec, Naprontag, Narocin, Naxopren, Prafena, Priaxen, Pronaxen, Rheumaflex, Saritilron, Sinartrin, Soproxen, Sutolin, Tohexen, Traumox, Flexen, Napxen, Noflam, Patxen, Rahsen, Sinton, Sutony, Velsay, Vinsen, Narma, Roxen, Anax, 2-Naphthaleneacetic acid, 6-methoxy-.alpha.-methyl-, (.alpha.S)-, CAS-22204-53-1, Flanax Forte, Naprosyn LLE, Proxen LE, Naxen F, Proxen LLE, U-Ritis, Naprosyn LLE Forte, (S)-2-(6-Methoxy-naphthalen-2-yl)-propionic acid, Naproxi 250, Naproxi 500, (S)-6-Methoxy-.alpha.-methyl-2-naphthaleneacetic acid, aproxen, Naxyn 250, Naxyn 500, Naprosine, Equiproxen (Veterinary), Mnpa, Naproxene [INN-French], Naproxenum [INN-Latin], Naproxeno [INN-Spanish], Xenar-CR, CCRIS 5265, HSDB 3369, EINECS 244-838-7, RS 3540, UNII-57Y76R9ATQ, Naprolag, Naprosy, Panoxen, Proxine, SR-01000075977, DL Naproxen, Naproxen CRS, Naprosyn (TN), NPS, Prestwick_349, (+)-2-(Methoxy-2-naphthyl)-propionsaeure [German], Naproxen (Standard), Naproxen [USAN:USP:INN:BAN:JAN], d-2-(6'-Methoxy-2'-naphthyl)-propionsaeure [German], S-NAPROXEN, Spectrum_000977, (R)-6-Methoxy-a-methyl-2-naphthaleneacetic acid, 4or0, 4po0, NAPROXEN [HSDB], NAPROXEN [USAN], (S)-(+)-Naproxene, NAPROXEN [INN], NAPROXEN [JAN], NAPROXEN [MI], NAPROXEN [VANDF], Prestwick0_000791, Prestwick1_000791, Prestwick2_000791, Spectrum2_001043, Spectrum3_000514, Spectrum4_000069, Spectrum5_001327, (+)NAPROXEN, NAPROXEN [MART.], Naproxen2-(6-Methoxy-naphthalen-2-yl)-propionic acid, Epitope ID:139974, NAPROXEN [USP-RS], NAPROXEN [WHO-DD], UPCMLD-DP001, 2-(6-Methoxy-naphthalen-2-yl)-propionic acid(Naproxen), EC 244-838-7, SCHEMBL3046, Lopac0_000792, BSPBio_002067, KBioGR_000597, KBioSS_001457, BIDD:GT0062, DivK1c_000242, NAPROXEN [GREEN BOOK], SPECTRUM1500425, Naproxen (JP18/USP/INN), Naproxen, 1mg/ml in Methanol, SPBio_000966, SPBio_002861, NAPROXEN [ORANGE BOOK], GTPL5230, orb1308096, orb3139913, NAPROXEN [EP MONOGRAPH], VIMOVO COMPONENT NAPROXEN, NAPROXEN [USP MONOGRAPH], SCHEMBL29350704, SCHEMBL29360045, UPCMLD-DP001:001, CMWTZPSULFXXJA-VIFPVBQESA-, HMS500M04, KBio1_000242, KBio2_001457, KBio2_004025, KBio2_006593, KBio3_001567, MSK7160, Naproxen 1.0 mg/ml in Methanol, NINDS_000242, GLXC-07868, HMS1920P13, HMS2089N21, HMS2091H12, HMS3649M13, HMS3886C15, Pharmakon1600-01500425, NAPROXEN COMPONENT OF PN400, Tox21_301953, BDBM50339185, CCG-40130, EBC-03706, HY-15030R, MSK7160-100A, NSC750183, NSC757239, AKOS005267223, MSK7160-1000A, AC-1363, DB00788, FN26157, ME-0100, NSC 750183, NSC 757239, SDCCGSBI-0050769.P005, IDI1_000242, Naproxen 100 microg/mL in Acetonitrile, NCGC00016759-01, NCGC00016759-02, NCGC00016759-03, NCGC00016759-29, NCGC00016759-38, NCGC00021127-01, NCGC00161591-01, NCGC00255562-01, HY-15030, SY015060, Naproxen, meets USP testing specifications, SBI-0050769.P004, M1021, Naproxen Solution in Acetonitrile, 100ug/mL, NS00098611, S5177, Naproxen Solution in Acetonitrile, 1000ug/mL, Naproxen, VETRANAL(TM), analytical standard, (S)-2-(6-methoxy-2-naphthyl)-propionic acid, (S)-2-(6-methoxynaphthalen-2-yl)propanoicacid, C01517, D00118, EN300-139795, O10203, (2S)-2-(6-methoxy(2-naphthyl))propanoic acid, AB00052049-04, AB00052049_05, (+)(S)2-(6-methoxy-2-naphthyl)-propionic acid, (S)-6-Methoxy-?-methyl-2-naphthaleneacetic acid, 2-(6-Methoxy-2-naphthyl)propanoic acid , (+)-, F079426, SR-01000003110, Q-201447, Q1215575, SR-01000003110-5, SR-01000075977-3, SR-01000075977-4, (+)-6-Methoxy-.alpha.-methyl-2-napthaleneacetic acid, (|_S)-6-Methoxy-|_-methyl-2-naphthaleneacetic acid, (|AS)-6-Methoxy-|A-methyl-2-naphthaleneacetic acid, BRD-K59197931-001-02-9, BRD-K59197931-001-03-7, BRD-K59197931-001-04-5, BRD-K59197931-236-09-6, BRD-K59197931-236-20-3, BRD-K59197931-236-21-1, BRD-K59197931-236-22-9, SR-01000075977-10, (+)-6-Methoxy-.alpha.-methyl-2-naphthaleneacetic acid, (S)-(+)-2-(6-methoxy-naphthalen-2-yl)-propionic acid, (S)-6-Methoxy-.alpha.-methyl-2-naphthalene acetic acid, Naproxen, British Pharmacopoeia (BP) Reference Standard, Naproxen, European Pharmacopoeia (EP) Reference Standard, Z1695772815, (S)-(+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid, 98%, 2-Naphthaleneacetic acid, 6-methoxy-.alpha.-methyl-, (+)-, Naproxen, United States Pharmacopeia (USP) Reference Standard, (+)-(S)-6-METHOXY-.ALPHA.-METHYL-2-NAPHTHALENEACETIC ACID, Naproxen, Pharmaceutical Secondary Standard, Certified Reference Material, (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic Acid, (S)-(+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic Acid, 131991-52-1, InChI=1/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1

Bioactivity: -

Solubility in Different Solvents

Solvent	Temperature [K]	Crystal form	Solubility [mg/mL]	Reference
1,4-Dioxane	304.65	-	350.1	[24]
1,4-Dioxane	311.05	-	396.0	[24]
1,4-Dioxane	312.15	-	409.4	[24]
1,4-Dioxane	316.85	-	446.3	[24]
1,4-Dioxane	319.95	-	481.0	[24]
1,4-Dioxane	322.85	-	501.5	[24]
1-Propanol	298.15	-	41.3	[228]
Acetone	278.25	-	3.032	[229]
Acetone	283.6	-	4.372	[229]
Acetone	288.3	-	5.2	[229]
Acetone	293.05	-	6.791	[229]
Acetone	298.15	-	153.0	[228]
Acetone	298.45	-	8.766	[229]
Acetone	303.2	-	11.21	[229]
Acetone	308.7	-	14.12	[229]
Acetone	313.45	-	18.11	[229]
Acetone	318.1	-	21.92	[229]
Acetone	320.15	-	25.51	[229]
Acetonitrile	298.15	-	26.21	[228]
Carbon tetrachloride	298.15	-	4.087	[228]
Chlorobenzene	298.15	-	14.42	[228]
Chloroform	298.15	-	74.64	[228]
Cyclohexane	298.15	-	0.159	[228]
Ethanol	278.15	-	19.64	[229]
Ethanol	283.7	-	24.34	[229]
Ethanol	288.15	-	30.24	[229]
Ethanol	293.1	-	36.76	[229]
Ethanol	293.2	-	49.54	[226]
Ethanol	293.2	-	42.68	[227]
Ethanol	298.15	-	55.34	[228]
Ethanol	298.2	-	59.35	[226]
Ethanol	298.2	-	46.46	[227]
Ethanol	298.5	-	46.76	[229]
Ethanol	303.2	-	78.83	[226]
Ethanol	303.2	-	51.0	[227]
Ethanol	303.25	-	56.61	[229]
Ethanol	308.2	-	92.16	[226]
Ethanol	308.2	-	54.7	[227]
Ethanol	308.65	-	67.84	[229]
Ethanol	313.2	-	112.8	[226]
Ethanol	313.2	-	59.95	[227]
Ethanol	313.4	-	83.52	[229]
Ethanol	318.8	-	96.74	[229]
Ethanol	320.15	-	110.0	[229]
Ethyl acetate	278.2	-	35.26	[229]
Ethyl acetate	283.45	-	41.64	[229]
Ethyl acetate	288.15	-	47.46	[229]
Ethyl acetate	293.1	-	55.26	[229]
Ethyl acetate	298.15	-	58.46	[228]
Ethyl acetate	298.5	-	65.07	[229]
Ethyl acetate	303.25	-	73.38	[229]
Ethyl acetate	308.65	-	86.09	[229]
Ethyl acetate	313.7	-	99.0	[229]
Ethyl acetate	318.7	-	113.4	[229]
Ethyl acetate	320.1	-	118.9	[229]
Ethylene Glycol	293.2	-	12.59	[227]
Ethylene Glycol	298.15	-	11.73	[228]
Ethylene Glycol	298.2	-	15.3	[227]
Ethylene Glycol	303.2	-	18.05	[227]
Ethylene Glycol	308.2	-	20.43	[227]
Ethylene Glycol	313.2	-	23.04	[227]
Heptane	298.15	-	0.0606	[228]
Hexane	298.15	-	0.056	[228]
Isopropanol	278.15	-	16.09	[229]
Isopropanol	283.6	-	20.35	[229]
Isopropanol	288.35	-	24.5	[229]
Isopropanol	293.75	-	29.62	[229]
Isopropanol	298.15	-	38.19	[228]
Isopropanol	298.5	-	35.76	[229]
Isopropanol	303.25	-	43.09	[229]
Isopropanol	308.65	-	53.27	[229]
Isopropanol	313.4	-	63.67	[229]
Isopropanol	318.8	-	77.81	[229]
Isopropanol	320.15	-	81.76	[229]
Methanol	278.2	-	35.65	[229]
Methanol	283.6	-	42.24	[229]
Methanol	288.15	-	50.45	[229]
Methanol	293.1	-	60.27	[229]
Methanol	298.15	-	69.79	[228]
Methanol	298.15	-	71.93	[229]
Methanol	303.9	-	87.77	[229]
Methanol	308.65	-	104.3	[229]
Methanol	313.4	-	122.4	[229]
Methanol	318.8	-	144.1	[229]
Methanol	320.15	-	154.6	[229]
Pentane	298.15	-	0.04401	[228]
Propylene Glycol	293.2	-	19.38	[226]
Propylene Glycol	298.2	-	22.86	[226]
Propylene Glycol	303.2	-	27.05	[226]
Propylene Glycol	308.2	-	33.25	[226]
Propylene Glycol	313.2	-	39.14	[226]
Toluene	298.15	-	7.503	[228]
Toluene	307.85	-	13.0	[24]
Toluene	315.85	-	17.0	[24]
Toluene	319.85	-	21.0	[24]
Toluene	323.15	-	25.5	[24]
Toluene	332.65	-	40.2	[24]
Water	293.2	-	0.0556	[226]
Water	298.2	-	0.06531	[226]
Water	303.2	-	0.07507	[226]
Water	308.2	-	0.0837	[226]
Water	313.2	-	0.09713	[226]

Molecule 3D descriptors

Descriptor	Value
PMI1	358.6231
PMI2	2561.8056
PMI3	2693.3145
NPR1	0.1332
NPR2	0.9512
RadiusOfGyration	3.4914
InertialShapeFactor	0.0027
Eccentricity	0.9911
Asphericity	0.6551
SpherocityIndex	0.1566
PBF	0.5102