Rivaroxaban

Molecular Mass: 435.9 g/mol

Formula: C₁₉H₁₈ClN₃O₅S

Smiles: O=C(NC[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1)c1ccc(Cl)s1

Synonymes:

Rivaroxaban, 366789-02-8, Xarelto, BAY 59-7939, BAY59-7939, BAY-59-7939, 9NDF7JZ4M3, 5-Chloro-N-({(5s)-2-Oxo-3-[4-(3-Oxomorpholin-4-Yl)phenyl]-1,3-Oxazolidin-5-Yl}methyl)thiophene-2-Carboxamide, JNJ39039039, JNJ-39039039, DTXSID3057723, CHEBI:68579, 5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide, 2-Thiophenecarboxamide, 5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-, 5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide, 5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide, 2-Thiophenecarboxamide, 5-chloro-N-(((5S)-2-oxo-3-(4-(3-oxo-4-morpholinyl)phenyl)-5-oxazolidinyl)methyl)-, rivaroxabanum, BAY 597939, BAY 59 7939, RefChem:6203, B01AF01, DTXCID601508635, (S)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide, 5-CHLORO-N-[[(S)-3-(4-(3-OXOMORPHOLIN-4-YL)PHENYL)-2-OXO-1,3-OXAZOLIDIN-5-YL]METHYL]-THIOPHENE-2-CARBOXAMIDE, MFCD11974010, C19H18ClN3O5S, 5-CHLORO-N-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]-2-THIOPHENECARBOXAMIDE, (S)-Rivaroxaban, Rivaroxaban (Xarelto), 5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl]thiophene-2-carboxamide, Xarelto (TN), Rivaroxaban [INN], UNII-9NDF7JZ4M3, Rivaroxaban CRS, HSDB 8149, 5-Chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl}thiophene-2-carboxamide, RIV, Rivaroxaban [USAN:INN:BAN:JAN], Rivaroxaban (Standard), RIVAROXABAN [MI], RIVAROXABAN [JAN], RIVAROXABAN [USAN], RIVAROXABAN [VANDF], SCHEMBL3914, RIVAROXABAN [MART.], RIVAROXABAN [USP-RS], RIVAROXABAN [WHO-DD], MLS006010027, Rivaroxaban (JAN/USAN/INN), RIVAROXABAN [EMA EPAR], BDBM7840, CHEMBL198362, GTPL6388, orb1309486, orb3141275, Rivaroxaban - Bio-X trade mark, BAY 59-7939 (Rivaroxaban), EX-A206, RIVAROXABAN [ORANGE BOOK], 2w26, KGFYHTZWPPHNLQ-AWEZNQCLSA-N, GLXC-90151, RIVAROXABAN [EP MONOGRAPH], Rivaroxaban,Xarelto,BAY 59-7939, EBC-07653, HY-50903R, MSK158364, AKOS005145918, CCG-212899, CS-0555, DB06228, FR27742, NCGC00262945-10, NCGC00379033-04, BR164355, HY-50903, SMR002529611, D07086, AB01563270_01, EN300-6733490, US8822458, 44, US8822458, 97, Q420262, SR-01000944189, SR-01000944189-1, BRD-K37130656-001-01-2, BRD-K37130656-001-03-8, Z1741977097, Rivaroxaban Working Standard (Secondary Reference Standard), (S)-5-chloro-N-{[2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl} thiophene-2-carboxamide, 1429742-50-6, 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide, 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl) phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide, 5-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide, 5-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophencarboxamide, 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide, 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide, 5-chloro-N-({(5s)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl} methyl)thiophene-2-carboxamide

Bioactivity: -

Solubility in Different Solvents

Solvent	Temperature [K]	Crystal form	Solubility [mg/mL]	Reference
1,4-Dioxane	288.15	-	0.6794	[298]
1,4-Dioxane	293.15	-	0.8107	[298]
1,4-Dioxane	298.15	-	0.9619	[298]
1,4-Dioxane	303.15	-	1.135	[298]
1,4-Dioxane	308.15	-	1.332	[298]
1,4-Dioxane	313.15	-	1.555	[298]
1,4-Dioxane	318.15	-	1.805	[298]
1,4-Dioxane	323.15	-	2.086	[298]
1,4-Dioxane	328.15	-	2.4	[298]
1,4-Dioxane	333.15	-	2.748	[298]
1-Butanol	283.15	-	0.0267	[296]
1-Butanol	288.15	-	0.03751	[296]
1-Butanol	293.15	-	0.05142	[296]
1-Butanol	298.15	-	0.07014	[296]
1-Butanol	303.15	-	0.09481	[296]
1-Butanol	308.15	-	0.1282	[296]
1-Propanol	283.15	-	0.04705	[296]
1-Propanol	288.15	-	0.0615	[296]
1-Propanol	293.15	-	0.07985	[296]
1-Propanol	298.15	-	0.1027	[296]
1-Propanol	303.15	-	0.1304	[296]
1-Propanol	308.15	-	0.1654	[296]
Acetone	273.15	-	0.2479	[298]
Acetone	278.15	-	0.3206	[298]
Acetone	283.15	-	0.4111	[298]
Acetone	288.15	-	0.5224	[298]
Acetone	293.15	-	0.6577	[298]
Acetone	298.15	-	0.8224	[298]
Acetone	303.15	-	1.02	[298]
Acetone	308.15	-	1.256	[298]
Acetone	313.15	-	1.536	[298]
Acetone	318.15	-	1.865	[298]
Acetonitrile	273.15	-	0.4117	[298]
Acetonitrile	278.15	-	0.5183	[298]
Acetonitrile	283.15	-	0.647	[298]
Acetonitrile	288.15	-	0.8015	[298]
Acetonitrile	293.15	-	0.9853	[298]
Acetonitrile	298.15	-	1.203	[298]
Acetonitrile	303.15	-	1.458	[298]
Acetonitrile	308.15	-	1.756	[298]
Acetonitrile	313.15	-	2.102	[298]
Acetonitrile	318.15	-	2.499	[298]
Dichloromethane	283.15	-	1.753	[296]
Dichloromethane	288.15	-	1.92	[296]
Dichloromethane	293.15	-	2.097	[296]
Dichloromethane	298.15	-	2.285	[296]
Dichloromethane	303.15	-	2.48	[296]
Dichloromethane	308.15	-	2.684	[296]
Dimethylacetamide	278.15	-	47.19	[297]
Dimethylacetamide	283.15	-	51.91	[297]
Dimethylacetamide	288.15	-	56.98	[297]
Dimethylacetamide	293.15	-	62.44	[297]
Dimethylacetamide	298.15	-	68.35	[297]
Dimethylacetamide	303.15	-	74.69	[297]
Dimethylacetamide	308.15	-	81.56	[297]
Dimethylacetamide	313.15	-	88.91	[297]
Dimethylacetamide	318.15	-	96.77	[297]
Dimethylformamide	278.15	-	33.87	[297]
Dimethylformamide	283.15	-	38.11	[297]
Dimethylformamide	288.15	-	42.8	[297]
Dimethylformamide	293.15	-	47.94	[297]
Dimethylformamide	298.15	-	53.63	[297]
Dimethylformamide	303.15	-	59.82	[297]
Dimethylformamide	308.15	-	66.59	[297]
Dimethylformamide	313.15	-	74.02	[297]
Dimethylformamide	318.15	-	82.21	[297]
Ethanol	283.15	-	0.09132	[296]
Ethanol	288.15	-	0.1096	[296]
Ethanol	293.15	-	0.1307	[296]
Ethanol	298.15	-	0.1553	[296]
Ethanol	303.15	-	0.185	[296]
Ethanol	308.15	-	2.16	[296]
Ethyl acetate	278.15	-	0.2347	[297]
Ethyl acetate	283.15	-	0.2678	[297]
Ethyl acetate	288.15	-	0.3044	[297]
Ethyl acetate	293.15	-	0.3451	[297]
Ethyl acetate	298.15	-	0.3899	[297]
Ethyl acetate	303.15	-	0.4394	[297]
Ethyl acetate	308.15	-	0.4937	[297]
Ethyl acetate	313.15	-	0.553	[297]
Ethyl acetate	318.15	-	0.6183	[297]
Methanol	283.15	-	0.2624	[296]
Methanol	288.15	-	0.3215	[296]
Methanol	293.15	-	0.3906	[296]
Methanol	298.15	-	0.4728	[296]
Methanol	303.15	-	0.5625	[296]
Methanol	308.15	-	0.6722	[296]
Methyl acetate	273.15	-	0.181	[298]
Methyl acetate	278.15	-	0.2271	[298]
Methyl acetate	283.15	-	0.2825	[298]
Methyl acetate	288.15	-	0.3491	[298]
Methyl acetate	293.15	-	0.428	[298]
Methyl acetate	298.15	-	0.5207	[298]
Methyl acetate	303.15	-	0.6299	[298]
Methyl acetate	308.15	-	0.7567	[298]
Methyl acetate	313.15	-	0.9033	[298]
Methyl acetate	318.15	-	1.071	[298]
Methyl ethyl ketone	273.15	-	0.1733	[298]
Methyl ethyl ketone	278.15	-	0.2257	[298]
Methyl ethyl ketone	283.15	-	0.291	[298]
Methyl ethyl ketone	288.15	-	0.3718	[298]
Methyl ethyl ketone	293.15	-	0.4707	[298]
Methyl ethyl ketone	298.15	-	0.5914	[298]
Methyl ethyl ketone	303.15	-	0.7374	[298]
Methyl ethyl ketone	308.15	-	0.9125	[298]
Methyl ethyl ketone	313.15	-	1.121	[298]
Methyl ethyl ketone	318.15	-	1.367	[298]
Tetrahydrofuran	278.15	-	1.123	[297]
Tetrahydrofuran	283.15	-	1.252	[297]
Tetrahydrofuran	288.15	-	1.421	[297]
Tetrahydrofuran	293.15	-	1.555	[297]
Tetrahydrofuran	298.15	-	1.752	[297]
Tetrahydrofuran	303.15	-	1.905	[297]
Tetrahydrofuran	308.15	-	2.113	[297]
Tetrahydrofuran	313.15	-	2.357	[297]
Tetrahydrofuran	318.15	-	2.659	[297]

Molecule 3D descriptors

Descriptor	Value
PMI1	1022.8462
PMI2	15396.9395
PMI3	15531.6734
NPR1	0.0659
NPR2	0.9913
RadiusOfGyration	6.0540
InertialShapeFactor	0.0010
Eccentricity	0.9978
Asphericity	0.8172
SpherocityIndex	0.0991
PBF	0.8224