Prednisolone

CAS Number: 50-24-8

Molecular Mass: 360.4 g/mol

Formula: C₂₁H₂₈O₅

Smiles: C[C@]12C=CC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO

Synonymes:

Prednisolone, prednisolone, 50-24-8, Metacortandralone, Hydroretrocortine, Deltacortril, Delta-Cortef, Codelcortone, Prenolone, Sterane, Deltahydrocortisone, Cortalone, Deltacortenol, Donisolone, Fernisolone, Hydrodeltalone, Paracortol, Hydeltra, Hydroretrocortin, Decortin H, Meti-Derm, Hydrodeltisone, Precortancyl, Predniliderm, Decaprednil, Delta F, Deltisilone, Dicortol, Estilsona, Hydeltrone, PRDL, Precortilon, Precortisyl, Prednelan, Prednicen, Scherisolon, Sterolone, Prelone, Steran, Ulacort, Delta-stab, Hostacortin H, Ultracorten H, Ultracortene-H, Predne-Dome, CO-Hydeltra, Eazolin D, Di-adreson F, Solone, Fernisolone-P, delta(1)-Hydrocortisone, delta(1)-Dehydrocortisol, Delta-Ef-Cortelan, Predniretard, 1-Dehydrohydrocortisone, Panafcortelone, Prednisolonum, 1,2-Dehydrohydrocortisone, 11beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione, delta(1)-Cortisol, Deltasolone, Klismacort, Delta(1)-dehydrohydrocortisone, 1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione, (11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione, 1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol, 3,20-Dioxo-11beta,17alpha,21-trihydroxy-1,4-pregnadiene, 9PHQ9Y1OLM, APREDNISLON, EQUISOLON, (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one, DTXSID9021184, NSC-9120, NSC-9900, Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-, CHEBI:8378, DTXCID301184, Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-, NSC9120, Adnisolone, Deltidrosol, Kuhlprednon, Lenisolone, Longiprednil, Predeltilone, Prednicortelone, Scheriproct, Capsoid, Dekotil, Dhasolone, Dilacort, Fisopred, Frisolona, Gupisone, Opredsone, Pevanti, Prenilone, Precortisyl fte, PrednisTab, Delta-Phoricol, DiAdresonF, Lepi-Cortinolo, Dontisolon D, Predni-Coelin, Dacortin H, Delta-Diona, Pred-Clysma, Predni-Helvacort, Prednisolone oral, Meti Derm, Delta-F, Di Adreson F, Linola-H-Fett N, Linola-H N, (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta(a)phenanthren-3-one, delta1-Hydrocortisone, Delta(1)Hydrocortisone, RefChem:6161, prednisolone oral solution, Delta1-dehydro-hydrocortisone, Prednisolone anhydrous Micronized, 200-021-7, Cortisolone, Deltalone, Predonine, Predonin, Cotogesic, Delcortol, Dydeltrone, Erbacort, Erbasona, Lentosone, Paracotol, Rolisone, Cordrol, Prednis, Fernisolone P, Derpo PD, Prednisolona, Dexa-Cortidelt hostacortin H, Prednisolonum [INN-Latin], Prednisolona [INN-Spanish], Ultracortene-hydrogen, 11beta,17alpha,21-Trihydroxypregna-1,4-diene-3,20-dione, NSC 9120, K 1557, .DELTA.1-Cortisol, Prednisolone (Standard), .DELTA.1-Hydrocortisone, .DELTA.1-Dehydrocortisol, CHEMBL131, .DELTA.1-Dehydrohydrocortisone, .delta.-Cortef, Neo-Delta-Cortef, .delta.-Stab, MFCD00003649, component of Ataraxoid, Cotolone, component of K-Predne-Dome, (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one, Supercortisol, delta(sup 1)-Cortisol, Bubbli-Pred, Prednisolone (1.0 mg/mL in Methanol), delta(sup 1)-Hydrocortisone, delta(sup 1)-Dehydrocortisol, SMR000718761, CCRIS 980, Prednisolone [INN:BAN:JAN], HSDB 3385, delta(sup 1)-Dehydrohydrocortisone, Pregna-1,20-dione, 11.beta.,17,21-trihydroxy-, EINECS 200-021-7, UNII-9PHQ9Y1OLM, Predisolone Sodium Phosphate, BRN 1354103, prednisolon, Hydrocortisone EP Impurity A, Preflam, Pregna-1,20-dione, 11,17,21-trihydroxy-, (11.beta.)-, Delta-Cortef, , Prednisolone CRS, CAS-50-24-8, NCGC00094764-01, Prednisolone Powder, delta-hydrocortisone, 1-Dehydrocortisol, , TUA, Prestwick_404, delta-dehydrocortisol, DELTA.1-Cortisol, VETSOLONE, Delta-Cortef (TN), 11-beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione, T-Pred (Salt/Mix), 1,4-Pregnadien-11-beta,17-alpha,21-triol-3,20-dione, 1,4-Pregnadiene-11-beta,17-alpha,21-triol-3,20-dione, 1,4-Pregnadiene-3,20-dione-11-beta,17-alpha,21-triol, Prednisolone, >=99%, Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11b)-, Prestwick0_000274, Prestwick1_000274, Prestwick2_000274, Prestwick3_000274, delta-dehydrohydrocortisone, PREDNISOLONE [EP], PREDNISOLONE [MI], (+)-PREDNISOLONE, PREDNISOLONE [INN], PREDNISOLONE [JAN], Prednisone impurity B CRS, EC 200-021-7, PREDNISOLONE [HSDB], SCHEMBL3233, K-Predne-Dome (Salt/Mix), PREDNISOLONE [VANDF], PREDNISOLONE ANHYDROUS, .DELTA.(sup 1)-Cortisol, BSPBio_000148, PREDNISOLONE [MART.], (1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one, 4-08-00-03467 (Beilstein Handbook Reference), MLS001304083, MLS002154250, MLS002207037, MLS002548883, PREDNISOLONE [USP-RS], PREDNISOLONE [WHO-DD], PREDNISOLONE [WHO-IP], SPBio_002367, BPBio1_000164, GTPL2866, US10196374, Prednisolone, SCHEMBL11040337, .DELTA.(sup 1)-Hydrocortisone, BDBM19190, Prednisolone (JP18/USP/INN), MSK2225, NSC9900, PREDNISOLONE [GREEN BOOK], .DELTA.(sup 1)-Dehydrocortisol, HMS1568H10, HMS2090J05, HMS2095H10, HMS2230P10, HMS3259E09, HMS3712H10, PREDNISOLONE [ORANGE BOOK], PREDNISOLONE [EP MONOGRAPH], PREDNISONE IMPURITY B [EP], NSC 9900, PREDNISOLONE [USP MONOGRAPH], Tox21_111327, Tox21_201673, Tox21_302987, EBC-12796, HY-17463R, LMST02030179, MSK2225-100A, MSK2225-100M, Prednisolone (1 mg/mL in Methanol), PREDNISOLONUM [WHO-IP LATIN], Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11.beta.)-, s1737, .DELTA.(sup 1)-Dehydrohydrocortisone, AKOS015894935, MSK2225-1000A, Tox21_111327_1, AC-1773, CCG-220274, DB00860, FP27131, NC00473, Prednisolone for system suitability CRS, Prednisolone for peak identification CRS, NCGC00179649-01, NCGC00179649-02, NCGC00179649-03, NCGC00179649-04, NCGC00179649-06, NCGC00256577-01, NCGC00259222-01, (1R,3aS,3bS,9aR,9bS,10S,11aS)-1,10-dihydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one, AS-13665, HY-17463, PREDNISOLONE (EMA EPAR: VETERINARY), CS-0695025, NS00000394, P0637, Prednisolone Solution in Methanol, 100ug/mL, EN300-53017, PREDNICARBATE IMPURITY A [EP IMPURITY], C07369, D00472, D91990, HYDROCORTISONE IMPURITY A [EP IMPURITY], Prednisolone Solution in Acetonitrile, 100ug/mL, Prednisolone, VETRANAL(TM), analytical standard, CHLOROPTIC-P S.O.P. COMPONENT PREDNISOLONE, F787580, METHYLPREDNISOLONE IMPURITY K [EP IMPURITY], Prednisolone Solution in Acetonitrile, 1000ug/mL, SR-01000837502, SR-01000837502-2, BRD-K98039984-001-03-0, BRD-K98039984-001-06-3, PREDNISOLONE ACETATE IMPURITY B [EP IMPURITY], Q11426176, 11beta,17,21-trihydroxy-1,4-pregnadiene-3,20-dione, Prednisolone, British Pharmacopoeia (BP) Assay Standard, Z778141968, 11-.beta.,17,21-Trihydroxypregna-1,4-diene-3,20-dione, (11?)-11,17,21-Trihydroxy-pregna-1,4-diene-3,20-dione, 1,4-Pregnadien-11-.beta.,17-.alpha.,21-triol-3,20-dione, 1,4-Pregnadiene-11-.beta.,17-.alpha.,21-triol-3,20-dione, 1,4-Pregnadiene-3,20-dione-11-.beta.,17-.alpha.,21-triol, Prednisolone, European Pharmacopoeia (EP) Reference Standard, Pregna-1,4-diene-3,20-dione, 11.beta.,17,21-trihydroxy-, 11,17,21-Trihydroxypregna-1,4-diene-3,20-dione, (11.beta.)-, 11-.beta.,17-.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione, 11-.beta.,17-.alpha.,21-Trihydroxypregna-1,4-diene-3,20-dione, 11.beta.,17.alpha.,21-Trihydroxypregna-1,4-diene-3,20-dione, Prednisolone, United States Pharmacopeia (USP) Reference Standard, Prednisolone for peak identification, European Pharmacopoeia (EP) Reference Standard, Prednisolone for system suitability, European Pharmacopoeia (EP) Reference Standard, Prednisolone, Pharmaceutical Secondary Standard, Certified Reference Material, (8S,9S,10R,11S,13S,14S,17R)-10,13-dimethyl-11,17-bis(oxidanyl)-17-(2-oxidanylethanoyl)-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one, 8056-11-9

Bioactivity: -

Solubility in Different Solvents

Solvent	Temperature [K]	Crystal form	Solubility [mg/mL]	Reference
1-Nonanol	293.2	-	1.049	[463]
1-Nonanol	298.2	-	1.325	[463]
1-Nonanol	303.2	-	1.71	[463]
1-Nonanol	308.2	-	2.042	[463]
1-Nonanol	313.2	-	2.565	[463]
1-Nonanol	318.2	-	3.062	[463]
1-Nonanol	323.2	-	3.614	[463]
1-Nonanol	328.2	-	4.324	[463]
1-Octanol	293.2	-	0.722	[463]
1-Octanol	298.2	-	0.9532	[463]
1-Octanol	303.2	-	1.287	[463]
1-Octanol	308.2	-	1.606	[463]
1-Octanol	313.2	-	2.05	[463]
1-Octanol	318.2	-	2.549	[463]
1-Octanol	323.2	-	3.14	[463]
1-Octanol	328.2	-	3.99	[463]
1-Pentanol	293.2	-	0.9428	[463]
1-Pentanol	298.2	-	1.187	[463]
1-Pentanol	303.2	-	1.483	[463]
1-Pentanol	308.2	-	1.838	[463]
1-Pentanol	313.2	-	2.288	[463]
1-Pentanol	318.2	-	2.871	[463]
1-Pentanol	323.2	-	3.57	[463]
1-Pentanol	328.2	-	4.489	[463]
2-Butanol	293.2	-	0.9727	[463]
2-Butanol	298.2	-	1.147	[463]
2-Butanol	303.2	-	1.405	[463]
2-Butanol	308.2	-	1.714	[463]
2-Butanol	313.2	-	2.03	[463]
2-Butanol	318.2	-	2.397	[463]
2-Butanol	323.2	-	2.85	[463]
2-Butanol	328.2	-	3.417	[463]
Acetonitrile	293.2	-	15.07	[463]
Acetonitrile	298.2	-	16.13	[463]
Acetonitrile	303.2	-	17.31	[463]
Acetonitrile	308.2	-	18.9	[463]
Acetonitrile	313.2	-	20.42	[463]
Acetonitrile	318.2	-	22.21	[463]
Acetonitrile	323.2	-	24.03	[463]
Acetonitrile	328.2	-	26.68	[463]
Dimethylformamide	293.2	-	38.58	[463]
Dimethylformamide	298.2	-	40.8	[463]
Dimethylformamide	303.2	-	44.08	[463]
Dimethylformamide	308.2	-	47.0	[463]
Dimethylformamide	313.2	-	50.03	[463]
Dimethylformamide	318.2	-	53.5	[463]
Dimethylformamide	323.2	-	57.4	[463]
Dimethylformamide	328.2	-	64.51	[463]
Dodecane	293.2	-	0.02283	[463]
Dodecane	298.2	-	0.02588	[463]
Dodecane	303.2	-	0.02936	[463]
Dodecane	308.2	-	0.03374	[463]
Dodecane	313.2	-	0.03808	[463]
Dodecane	318.2	-	0.04315	[463]
Dodecane	323.2	-	0.05047	[463]
Dodecane	328.2	-	0.05848	[463]
N-Methyl-2-pyrrolidone	293.2	-	17.54	[463]
N-Methyl-2-pyrrolidone	298.2	-	19.73	[463]
N-Methyl-2-pyrrolidone	303.2	-	22.8	[463]
N-Methyl-2-pyrrolidone	308.2	-	25.68	[463]
N-Methyl-2-pyrrolidone	313.2	-	29.16	[463]
N-Methyl-2-pyrrolidone	318.2	-	32.66	[463]
N-Methyl-2-pyrrolidone	323.2	-	36.87	[463]
N-Methyl-2-pyrrolidone	328.2	-	41.99	[463]
Water	293.2	-	0.2097	[463]
Water	298.2	-	0.219	[463]
Water	303.2	-	0.2485	[463]
Water	308.2	-	0.278	[463]
Water	313.2	-	0.317	[463]
Water	318.2	-	0.356	[463]
Water	323.2	-	0.39	[463]
Water	328.2	-	0.511	[463]

Molecule 3D descriptors

Descriptor	Value
PMI1	1054.4413
PMI2	4645.3203
PMI3	4950.7457
NPR1	0.2130
NPR2	0.9383
RadiusOfGyration	3.8437
InertialShapeFactor	0.0009
Eccentricity	0.9771
Asphericity	0.4967
SpherocityIndex	0.3211
PBF	0.9925