Flutamide

CAS Number: 13311-84-7

Molecular Mass: 276.21 g/mol

Formula: C₁₁H₁₁F₃N₂O₃

Smiles: CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1

Synonymes:

Flutamide, flutamide, 13311-84-7, Eulexin, Niftolide, Drogenil, Sch 13521, 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide, niftolid, NFBA, Flutamida, Flutamidum, Sch-13521, Eulexine, 4'-Nitro-3'-trifluoromethylisobutyranilide, 2-Methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide, Propanamide, 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-, SCH13521, DTXSID7032004, alpha,alpha,alpha-Trifluoro-2-methyl-4'-nitro-m-propionotoluidide, NSC-215876, Propanamide, 2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-, 76W6J0943E, CHEBI:5132, DTXCID9011121, Flutacell, ApoFlutamide, NovoFlutamide, Apo Flutamide, Fluta cell, Novo Flutamide, FlutaGRY, PMS Flutamide, Fluta GRY, 2-Methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)propanamide, RefChem:55220, L02BB01, 236-341-9, Euflex, Niftholide, Flutamin, Cebatrol, veterinary, N-(4-NITRO-3-(TRIFLUOROMETHYL)PHENYL)ISOBUTYRAMIDE, MFCD00072009, NSC 215876, CHEMBL806, 4-Nitro-3-(trifluoromethyl)isobutyranilide, 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propionamide, NCGC00015452-09, Chimax, Odyne, 4'-Nitro-3'-trifluoromethylisobutyramilide, CAS-13311-84-7, Ham's F-12 medium, Flutamidum [INN-Latin], Flutamida [INN-Spanish], Flutamide USP25, N-[4-Nitro-3-(trifluoromethyl)phenyl]isobutyramide, Prostandril, .alpha.,.alpha.,.alpha.-Trifluoro-2-methyl-4'-nitro-m-propionotoluidide, SMR000058187, Eulexin (TN), CCRIS 7246, m-Propionotoluidide,.alpha.,.alpha.-trifluoro-, SR-01000075888, EINECS 236-341-9, NK-601, BRN 2157663, .alpha.,.alpha.-Trifluoro-2-methyl-4'-nitro-m-propionotoluidide, m-Propionotoluidide,.alpha.,.alpha.-trifluoro-2-methyl-4'-nitro-, Flutamide CRS, UNII-76W6J0943E, 4'-Nitro-3'-(trifluoromethyl)isobutyranilide, Flutamide [USAN:USP:INN:BAN], Prestwick_228, Flutamide (Eulexin), Flutamide (Standard), Spectrum_001210, CPD000058187, FLUTAMIDE [INN], FLUTAMIDE [JAN], FLUTAMIDE [MI], FLUTAMIDE [USAN], Prestwick0_000180, Prestwick1_000180, Prestwick2_000180, Prestwick3_000180, Spectrum2_001201, Spectrum3_001421, Spectrum4_000829, Spectrum5_001450, Lopac-F-9397, F0663, Flutamide (pubertal study), FLUTAMIDE [MART.], F 9397, FLUTAMIDE [USP-RS], FLUTAMIDE [WHO-DD], SCHEMBL3934, Lopac0_000557, BSPBio_000079, BSPBio_003122, KBioGR_001377, KBioSS_001690, MLS000069634, MLS001065596, MLS002548892, DivK1c_000459, SPECTRUM1500995, Flutamide - Bio-X trade mark, SPBio_000982, SPBio_002000, Flutamide (JP18/USP/INN), BPBio1_000087, GTPL6943, orb1310563, FLUTAMIDE [EP IMPURITY], FLUTAMIDE [ORANGE BOOK], CHEMBL4759307, FLUTAMIDE [EP MONOGRAPH], SCHEMBL12932289, SCHEMBL29349783, HMS501G21, HY-B0022R, KBio1_000459, KBio2_001690, KBio2_004258, KBio2_006826, KBio3_002342, FLUTAMIDE [USP MONOGRAPH], NINDS_000459, GLXC-07722, HMS1568D21, HMS1921O16, HMS2090I18, HMS2092O14, HMS2095D21, HMS2230P19, HMS3259I03, HMS3261P15, HMS3373C12, HMS3655G22, HMS3712D21, HMS5080H03, Pharmakon1600-01500995, HY-B0022, MSK11432, YIA13472, Tox21_110154, Tox21_202169, Tox21_300536, Tox21_500557, BDBM50131270, CCG-39105, EBC-03834, m-Propionotoluidide, 2-methyl-4'-nitro-alpha,alpha,alpha-triflouro-, m-Propionotoluidide, alpha,alpha,alpha-trifluoro-2-methyl-4'-nitro-, NSC147834, NSC215876, NSC757817, s1908, SBB006930, AKOS001025465, AKOS015994751, AKOS025243203, m-Propionotoluidide, .alpha.,.alpha.,.alpha.-trifluoro-2-methyl-4'-nitro-, Tox21_110154_1, AB02835, DB00499, FF23510, KS-5091, LP00557, NC00451, NSC-147834, NSC-757817, SDCCGSBI-0050540.P004, IDI1_000459, NCGC00015452-01, NCGC00015452-02, NCGC00015452-03, NCGC00015452-04, NCGC00015452-05, NCGC00015452-06, NCGC00015452-07, NCGC00015452-08, NCGC00015452-10, NCGC00015452-11, NCGC00015452-12, NCGC00015452-13, NCGC00015452-14, NCGC00015452-15, NCGC00015452-16, NCGC00015452-19, NCGC00015452-20, NCGC00015452-32, NCGC00091460-01, NCGC00091460-02, NCGC00091460-03, NCGC00091460-04, NCGC00091460-05, NCGC00091460-06, NCGC00091460-07, NCGC00091460-08, NCGC00091460-09, NCGC00254495-01, NCGC00259718-01, NCGC00261242-01, AC-24192, BF166239, ST058409, SY036411, SBI-0050540.P003, DB-042163, 3'-Trifluoromethyl-4'-Nitro-Isobutyranilide, AB00052188, EU-0100557, NS00002675, SW196536-4, T0489, 4''-nitro-3''-trifluoromethylisobutyranilide, A10796, C07653, D00586, EN300-119548, AB00052188-09, AB00052188_10, AB00052188_11, F358096, Q418669, SR-01000075888-1, SR-01000075888-6, SR-01000075888-7, SR-01000075888-9, BRD-K28307902-001-05-0, BRD-K28307902-001-20-9, BRD-K28307902-001-21-7, Flutamide, certified reference material, TraceCERT(R), Z56755651, Flutamide, European Pharmacopoeia (EP) Reference Standard, N1-[4-nitro-3-(trifluoromethyl)phenyl]-2-methylpropanamide, 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide #, Flutamide, United States Pharmacopeia (USP) Reference Standard, alpha,alpha,alpha-trifluoro-2-methyl-4''-nitro-m-propionotoluidide, m-Propionotoluidide, 2-methyl-4'-nitro-.alpha.,.alpha.,.alpha.-trifluoro-, Flutamide for system suitability, European Pharmacopoeia (EP) Reference Standard, 37209-54-4

Bioactivity: -

Solubility in Different Solvents

Solvent	Temperature [K]	Crystal form	Solubility [mg/mL]	Reference
1,4-Dioxane	283.15	-	448.0	[146]
1,4-Dioxane	283.15	-	397.0	[147]
1,4-Dioxane	288.15	-	527.3	[146]
1,4-Dioxane	288.15	-	476.4	[147]
1,4-Dioxane	293.15	-	619.5	[146]
1,4-Dioxane	293.15	-	578.5	[147]
1,4-Dioxane	298.15	-	729.1	[146]
1,4-Dioxane	298.15	-	692.6	[147]
1,4-Dioxane	303.15	-	853.1	[146]
1,4-Dioxane	303.15	-	816.2	[147]
1,4-Dioxane	308.15	-	999.6	[146]
1,4-Dioxane	308.15	-	957.0	[147]
1,4-Dioxane	313.15	-	1184.0	[146]
1,4-Dioxane	313.15	-	1125.5	[147]
1,4-Dioxane	318.15	-	1399.6	[146]
1,4-Dioxane	318.15	-	1345.8	[147]
1,4-Dioxane	323.15	-	1600.5	[146]
1,4-Dioxane	323.15	-	1671.0	[147]
1-Butanol	278.15	-	157.8	[147]
1-Butanol	283.15	-	176.9	[147]
1-Butanol	288.15	-	201.1	[147]
1-Butanol	293.15	-	230.3	[147]
1-Butanol	298.15	-	260.0	[147]
1-Butanol	303.15	-	297.2	[147]
1-Butanol	308.15	-	341.6	[147]
1-Butanol	313.15	-	393.2	[147]
1-Butanol	318.15	-	461.4	[147]
1-Butanol	323.15	-	541.1	[147]
1-Propanol	278.15	-	193.3	[147]
1-Propanol	283.15	-	216.1	[147]
1-Propanol	288.15	-	246.9	[147]
1-Propanol	293.15	-	276.9	[147]
1-Propanol	298.15	-	312.8	[147]
1-Propanol	303.15	-	356.9	[147]
1-Propanol	308.15	-	408.3	[147]
1-Propanol	313.15	-	470.9	[147]
1-Propanol	318.15	-	547.3	[147]
1-Propanol	323.15	-	634.0	[147]
2-Methoxyethanol	278.15	-	490.6	[148]
2-Methoxyethanol	283.15	-	529.5	[148]
2-Methoxyethanol	288.15	-	582.6	[148]
2-Methoxyethanol	293.15	-	634.1	[148]
2-Methoxyethanol	298.15	-	695.6	[148]
2-Methoxyethanol	303.15	-	759.9	[148]
2-Methoxyethanol	308.15	-	835.4	[148]
2-Methoxyethanol	313.15	-	922.4	[148]
2-Methoxyethanol	318.15	-	1019.7	[148]
2-Methoxyethanol	323.15	-	1133.0	[148]
Acetone	278.15	-	875.7	[147]
Acetone	278.15	-	743.9	[148]
Acetone	283.15	-	959.5	[147]
Acetone	283.15	-	800.1	[148]
Acetone	288.15	-	1119.7	[147]
Acetone	288.15	-	858.0	[148]
Acetone	293.15	-	1306.6	[147]
Acetone	293.15	-	917.7	[148]
Acetone	298.15	-	1533.6	[147]
Acetone	298.15	-	986.2	[148]
Acetone	303.15	-	1799.5	[147]
Acetone	303.15	-	1063.9	[148]
Acetone	308.15	-	2120.2	[147]
Acetone	308.15	-	1148.2	[148]
Acetone	313.15	-	2502.5	[147]
Acetone	313.15	-	1250.0	[148]
Acetone	318.15	-	2956.6	[147]
Acetone	318.15	-	1359.0	[148]
Acetone	323.15	-	3460.2	[147]
Acetone	323.15	-	1488.5	[148]
Acetonitrile	278.15	-	338.0	[146]
Acetonitrile	278.15	-	322.2	[147]
Acetonitrile	283.15	-	432.2	[146]
Acetonitrile	283.15	-	408.3	[147]
Acetonitrile	288.15	-	549.0	[146]
Acetonitrile	288.15	-	525.3	[147]
Acetonitrile	293.15	-	683.3	[146]
Acetonitrile	293.15	-	712.4	[147]
Acetonitrile	298.15	-	880.6	[146]
Acetonitrile	298.15	-	975.3	[147]
Acetonitrile	303.15	-	1119.2	[146]
Acetonitrile	303.15	-	1276.5	[147]
Acetonitrile	308.15	-	1424.7	[146]
Acetonitrile	308.15	-	1677.4	[147]
Acetonitrile	313.15	-	1811.7	[146]
Acetonitrile	313.15	-	2155.2	[147]
Acetonitrile	318.15	-	2327.6	[146]
Acetonitrile	318.15	-	2790.6	[147]
Acetonitrile	323.15	-	3026.7	[146]
Acetonitrile	323.15	-	3762.1	[147]
Dichloromethane	278.15	-	32.46	[148]
Dichloromethane	283.15	-	40.77	[148]
Dichloromethane	288.15	-	51.35	[148]
Dichloromethane	293.15	-	62.75	[148]
Dichloromethane	298.15	-	79.19	[148]
Dichloromethane	303.15	-	96.86	[148]
Dichloromethane	308.15	-	118.6	[148]
Dimethyl sulfoxide	293.15	-	2971.0	[148]
Dimethyl sulfoxide	298.15	-	3086.3	[148]
Dimethyl sulfoxide	303.15	-	3214.6	[148]
Dimethyl sulfoxide	308.15	-	3385.1	[148]
Dimethyl sulfoxide	313.15	-	3534.1	[148]
Dimethyl sulfoxide	318.15	-	3737.0	[148]
Dimethyl sulfoxide	323.15	-	3970.0	[148]
Dimethylformamide	278.15	-	2250.0	[148]
Dimethylformamide	283.15	-	2322.4	[148]
Dimethylformamide	288.15	-	2408.4	[148]
Dimethylformamide	293.15	-	2490.0	[148]
Dimethylformamide	298.15	-	2595.0	[148]
Dimethylformamide	303.15	-	2715.2	[148]
Dimethylformamide	308.15	-	2856.1	[148]
Dimethylformamide	313.15	-	3012.2	[148]
Dimethylformamide	318.15	-	3175.2	[148]
Dimethylformamide	323.15	-	3395.9	[148]
Ethanol	278.15	-	182.6	[146]
Ethanol	278.15	-	254.6	[147]
Ethanol	278.15	-	167.2	[148]
Ethanol	283.15	-	217.6	[146]
Ethanol	283.15	-	281.6	[147]
Ethanol	283.15	-	202.5	[148]
Ethanol	288.15	-	262.0	[146]
Ethanol	288.15	-	319.9	[147]
Ethanol	288.15	-	251.8	[148]
Ethanol	293.15	-	311.2	[146]
Ethanol	293.15	-	361.4	[147]
Ethanol	293.15	-	294.6	[148]
Ethanol	298.15	-	370.0	[146]
Ethanol	298.15	-	408.0	[147]
Ethanol	298.15	-	353.7	[148]
Ethanol	303.15	-	439.3	[146]
Ethanol	303.15	-	467.5	[147]
Ethanol	303.15	-	423.7	[148]
Ethanol	308.15	-	518.4	[146]
Ethanol	308.15	-	529.7	[147]
Ethanol	308.15	-	505.2	[148]
Ethanol	313.15	-	606.9	[146]
Ethanol	313.15	-	615.3	[147]
Ethanol	313.15	-	604.5	[148]
Ethanol	318.15	-	722.6	[146]
Ethanol	318.15	-	707.9	[147]
Ethanol	318.15	-	720.8	[148]
Ethanol	323.15	-	847.7	[146]
Ethanol	323.15	-	832.3	[147]
Ethanol	323.15	-	858.6	[148]
Ethyl acetate	278.15	-	553.6	[147]
Ethyl acetate	278.15	-	319.1	[148]
Ethyl acetate	283.15	-	618.0	[147]
Ethyl acetate	283.15	-	351.2	[148]
Ethyl acetate	288.15	-	671.9	[147]
Ethyl acetate	288.15	-	384.9	[148]
Ethyl acetate	293.15	-	731.6	[147]
Ethyl acetate	293.15	-	425.9	[148]
Ethyl acetate	298.15	-	824.2	[147]
Ethyl acetate	298.15	-	469.4	[148]
Ethyl acetate	303.15	-	909.6	[147]
Ethyl acetate	303.15	-	514.4	[148]
Ethyl acetate	308.15	-	1016.7	[147]
Ethyl acetate	308.15	-	565.3	[148]
Ethyl acetate	313.15	-	1122.8	[147]
Ethyl acetate	313.15	-	630.3	[148]
Ethyl acetate	318.15	-	1286.7	[147]
Ethyl acetate	318.15	-	702.5	[148]
Ethyl acetate	323.15	-	1463.0	[147]
Ethyl acetate	323.15	-	786.2	[148]
Ethylene Glycol	278.15	-	4.45	[148]
Ethylene Glycol	283.15	-	5.789	[148]
Ethylene Glycol	288.15	-	7.47	[148]
Ethylene Glycol	293.15	-	9.68	[148]
Ethylene Glycol	298.15	-	11.93	[148]
Ethylene Glycol	303.15	-	15.21	[148]
Ethylene Glycol	308.15	-	19.2	[148]
Ethylene Glycol	313.15	-	24.14	[148]
Ethylene Glycol	318.15	-	29.92	[148]
Ethylene Glycol	323.15	-	37.12	[148]
Glycol monoethyl ether	278.15	-	441.8	[148]
Glycol monoethyl ether	283.15	-	477.1	[148]
Glycol monoethyl ether	288.15	-	516.1	[148]
Glycol monoethyl ether	293.15	-	558.8	[148]
Glycol monoethyl ether	298.15	-	607.5	[148]
Glycol monoethyl ether	303.15	-	660.0	[148]
Glycol monoethyl ether	308.15	-	720.7	[148]
Glycol monoethyl ether	313.15	-	789.1	[148]
Glycol monoethyl ether	318.15	-	864.6	[148]
Glycol monoethyl ether	323.15	-	959.1	[148]
Isobutanol	278.15	-	96.17	[147]
Isobutanol	283.15	-	119.6	[147]
Isobutanol	288.15	-	153.8	[147]
Isobutanol	293.15	-	201.7	[147]
Isobutanol	298.15	-	250.0	[147]
Isobutanol	303.15	-	316.1	[147]
Isobutanol	308.15	-	394.6	[147]
Isobutanol	313.15	-	482.1	[147]
Isobutanol	318.15	-	603.2	[147]
Isobutanol	323.15	-	756.3	[147]
Isopropanol	278.15	-	227.2	[146]
Isopropanol	278.15	-	209.0	[147]
Isopropanol	283.15	-	259.5	[146]
Isopropanol	283.15	-	237.0	[147]
Isopropanol	288.15	-	297.0	[146]
Isopropanol	288.15	-	269.8	[147]
Isopropanol	293.15	-	340.3	[146]
Isopropanol	293.15	-	313.8	[147]
Isopropanol	298.15	-	389.7	[146]
Isopropanol	298.15	-	362.8	[147]
Isopropanol	303.15	-	442.3	[146]
Isopropanol	303.15	-	420.4	[147]
Isopropanol	308.15	-	506.4	[146]
Isopropanol	308.15	-	488.4	[147]
Isopropanol	313.15	-	575.0	[146]
Isopropanol	313.15	-	570.1	[147]
Isopropanol	318.15	-	646.4	[146]
Isopropanol	318.15	-	672.9	[147]
Isopropanol	323.15	-	748.0	[146]
Isopropanol	323.15	-	776.8	[147]
Methanol	278.15	-	289.6	[147]
Methanol	278.15	-	212.0	[148]
Methanol	283.15	-	340.0	[147]
Methanol	283.15	-	259.5	[148]
Methanol	288.15	-	403.0	[147]
Methanol	288.15	-	320.2	[148]
Methanol	293.15	-	466.9	[147]
Methanol	293.15	-	383.4	[148]
Methanol	298.15	-	554.9	[147]
Methanol	298.15	-	471.3	[148]
Methanol	303.15	-	648.4	[147]
Methanol	303.15	-	570.2	[148]
Methanol	308.15	-	765.4	[147]
Methanol	308.15	-	688.9	[148]
Methanol	313.15	-	911.1	[147]
Methanol	313.15	-	821.9	[148]
Methanol	318.15	-	1094.7	[147]
Methanol	318.15	-	993.7	[148]
Methanol	323.15	-	1309.5	[147]
Methanol	323.15	-	1190.2	[148]
Methyl acetate	278.15	-	581.5	[147]
Methyl acetate	278.15	-	370.8	[148]
Methyl acetate	283.15	-	659.0	[147]
Methyl acetate	283.15	-	405.4	[148]
Methyl acetate	288.15	-	765.6	[147]
Methyl acetate	288.15	-	448.3	[148]
Methyl acetate	293.15	-	913.7	[147]
Methyl acetate	293.15	-	487.7	[148]
Methyl acetate	298.15	-	1089.2	[147]
Methyl acetate	298.15	-	539.7	[148]
Methyl acetate	303.15	-	1305.0	[147]
Methyl acetate	303.15	-	575.9	[148]
Methyl acetate	308.15	-	1547.6	[147]
Methyl acetate	308.15	-	649.9	[148]
Methyl acetate	313.15	-	1823.7	[147]
Methyl acetate	313.15	-	718.4	[148]
Methyl acetate	318.15	-	2196.6	[147]
Methyl acetate	318.15	-	797.0	[148]
Methyl acetate	323.15	-	2693.0	[147]
Methyl acetate	323.15	-	888.8	[148]
Tetrahydrofuran	278.15	-	1208.6	[147]
Tetrahydrofuran	283.15	-	1314.5	[147]
Tetrahydrofuran	288.15	-	1447.4	[147]
Tetrahydrofuran	293.15	-	1604.5	[147]
Tetrahydrofuran	298.15	-	1804.2	[147]
Tetrahydrofuran	303.15	-	2022.3	[147]
Tetrahydrofuran	308.15	-	2271.0	[147]
Tetrahydrofuran	313.15	-	2563.2	[147]
Tetrahydrofuran	318.15	-	2913.7	[147]
Tetrahydrofuran	323.15	-	3300.2	[147]
Water	278.15	-	0.0037	[146]
Water	283.15	-	0.0049	[146]
Water	288.15	-	0.0062	[146]
Water	293.15	-	0.008	[146]
Water	298.15	-	0.0102	[146]
Water	303.15	-	0.0128	[146]
Water	308.15	-	0.0163	[146]
Water	313.15	-	0.0201	[146]
Water	318.15	-	0.0251	[146]
Water	323.15	-	0.0312	[146]

Molecule 3D descriptors

Descriptor	Value
PMI1	660.0505
PMI2	2919.0773
PMI3	3381.2035
NPR1	0.1952
NPR2	0.8633
RadiusOfGyration	3.5496
InertialShapeFactor	0.0013
Eccentricity	0.9808
Asphericity	0.5252
SpherocityIndex	0.1064
PBF	0.5534